4.8 Review

Polymer mechanochemistry in drug delivery: From controlled release to precise activation

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Mechanoresponsive Metal-Organic Cage-Crosslinked Polymer Hydrogels

Robin Kueng et al.

Summary: We have developed metal-organic cage-crosslinked polymer hydrogels by using bipyridine-functionalized polyethylene glycol chains. These hydrogels can encapsulate guest molecules and can be disassembled by ultrasound to release the cargo. The performance of the hydrogels was characterized by various techniques, including NMR, rheology, and SAXS experiments. The study also reveals the mechanism of cage-opening and demonstrates the enhanced drug-loading capacity of the hydrogels compared to non-crosslinked assemblies.

CHEMISTRY-A EUROPEAN JOURNAL (2023)

Article Chemistry, Multidisciplinary

Mechanically Triggered Carbon Monoxide Release with Turn-On Aggregation-Induced Emission

Yunyan Sun et al.

Summary: Polymers that release small molecules under mechanical stress have potential applications in catalysis, sensing, and mechanochemical dynamic therapy. In this study, a dual mechanophore based on a unique mechanochemical reaction involving norborn-2-en-7-one (NEO) is demonstrated. The polymers can release carbon monoxide (CO) and exhibit bright cyan emission upon mechanical activation.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Review Biochemistry & Molecular Biology

A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives

Peng Liu et al.

Summary: Liposomes have been widely recognized as promising drug carriers due to their superior properties. This review discusses the liposomal drug products approved by FDA and EMA, providing valuable information on their critical chemistry and pharmaceutical technologies. Moreover, it summarizes the current regulatory guidance and future perspectives related to liposomal products.

MOLECULES (2022)

Article Polymer Science

Activation of Antibiotic-Grafted Polymer Brushes by Ultrasound

Miancheng Zou et al.

Summary: The ultrasound-mediated activation of drugs from macromolecular structures is a promising strategy for achieving spatiotemporal control over drug activity. However, conceptual challenges such as low drugloading content and efficiency limit its applicability. A new carrier design has been proposed to increase drug-loading content, mechanochemical efficiency, and drug potency, providing a design guideline for future research in sonopharmacology.

ACS MACRO LETTERS (2022)

Article Polymer Science

Microgels as drug carriers for sonopharmacology

Miancheng Zou et al.

Summary: The ultrasound-triggered release of covalently anchored drugs from polymer scaffolds is improved by altering the polymer topology. The use of microgels reduces sonication times and shields the drug cargo from non-triggered activation.

JOURNAL OF POLYMER SCIENCE (2022)

Article Multidisciplinary Sciences

Safe and efficient 2D molybdenum disulfide platform for cooperative imaging-guided photothermal-selective chemotherapy: A preclinical study

Xin Li et al.

Summary: This study presents the development of a safe and efficient multimodal therapeutic platform for the targeted treatment of ovarian carcinoma. The platform achieves selective chemotherapy for cancer cells and high photothermal efficiency under near-infrared irradiation, leading to remarkable efficacy and safety benefits in vivo.

JOURNAL OF ADVANCED RESEARCH (2022)

Article Polymer Science

Incorporation of a Tethered Alcohol Enables Efficient Mechanically Triggered Release in Aprotic Environments

Corey C. Husic et al.

Summary: This study presents a new design of mechanophore polymer container that can release chemical payloads efficiently in non-proton solvent environments. The design incorporates a tethered primary alcohol and an intramolecular hydrogen bonding interaction between the alcohol and the carbonyl oxygen of a carbonate, reducing the activation energy for carbonate fragmentation and enabling molecular release. This design expands the application range of mechanically triggered release.

ACS MACRO LETTERS (2022)

Article Chemistry, Multidisciplinary

Urea-Bond Scission Induced by Therapeutic Ultrasound for Biofunctional Molecule Release

Yunkang Tong et al.

Summary: Ultrasound-triggered scission of urea bonds for drug release has been demonstrated using therapeutic ultrasound. This transformation is initiated by hydroxyl radicals and occurs specifically at the cavitation bubble-liquid interface. The released drug can be selectively delivered in a physiologically relevant environment, showing great potential in cancer treatment.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Review Chemistry, Multidisciplinary

Recent advances in mechanical force-responsive drug delivery systems

Panqin Ma et al.

Summary: This tutorial review comprehensively evaluates recent advances in mechanical force-responsive drug delivery systems, providing guidance for potential clinical translational research.

NANOSCALE ADVANCES (2022)

Article Multidisciplinary Sciences

Ultrasound controlled mechanophore activation in hydrogels for cancer therapy

Gun Kim et al.

Summary: This paper reports an in vitro demonstration of a noninvasive cancer therapy using mechanophore embedded in biocompatible hydrogels to generate reactive oxygen species (ROS) under high-intensity focused ultrasound (HIFU) activation, effectively killing tumor cells. This mechanochemical dynamic therapy (MDT) combines the advantages of mechanophores and HIFU to provide a noninvasive treatment for diverse cancers.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Chemistry, Multidisciplinary

The Mechanochemical Release of Naphthalimide Fluorophores from beta-Carbonate and beta-Carbamate Disulfide-Centered Polymers

Zhiyuan Shi et al.

Summary: The covalent attachment of cargo molecules in beta-position to a disulfide moiety through carbamate and carbonate bonds, combined with polymer mechanochemistry-induced disulfide scission, allows for remote-controlled release of small molecule drugs and fluorophores. The nature of the linker bond largely governs the subsequent release kinetics, which is crucial for tailoring release rates in force-induced pharmacotherapy.

CCS CHEMISTRY (2021)

Review Nanoscience & Nanotechnology

The role of polymer mechanochemistry in responsive materials and additive manufacturing

Maroun Abi Ghanem et al.

Summary: Polymer mechanochemistry involves converting mechanical forces in materials to chemical reactions through the response of functional groups known as mechanophores. This technology has applications in materials science, polymer physics, and additive manufacturing. The historical development of using mechanical force to chemically transform polymers spans decades, leading to a range of engineered molecular responses that impact optical, mechanical, electronic, and thermal properties.

NATURE REVIEWS MATERIALS (2021)

Article Chemistry, Multidisciplinary

Harnessing the Power of Force: Development of Mechanophores for Molecular Release

Brooke A. Versaw et al.

Summary: Mechanophores, stress-sensitive molecules that release small molecules from polymers, show great promise in achieving selective and controlled release of covalently bound payloads. While the field of polymer mechanochemistry is rapidly advancing, further fundamental and technological advancements are still needed for significant impact in this research area.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Review Biochemistry & Molecular Biology

Controlled Drug Delivery Systems: Current Status and Future Directions

Shivakalyani Adepu et al.

Summary: The paper discusses the evolution of drug delivery systems, the limitations of conventional drug delivery, and the details of controlled drug delivery systems, including design considerations, classifications, and recent research findings on nano-drug delivery, targeted drug delivery, and smart drug delivery using intelligent biomaterials. The challenges and future directions in controlled drug delivery are also addressed in the conclusion.

MOLECULES (2021)

Article Chemistry, Multidisciplinary

Mechanochemical bond scission for the activation of drugs

Shuaidong Huo et al.

Summary: This study demonstrated the potential of ultrasound to activate mechanoresponsive prodrug systems by controlled scission of covalent and non-covalent bonds, releasing various drugs and showing a promising new strategy for drug activation.

NATURE CHEMISTRY (2021)

Editorial Material Chemistry, Multidisciplinary

The liberating force of ultrasound

Roman Boulatov

NATURE CHEMISTRY (2021)

Review Polymer Science

Micellar Drug Delivery Systems Based on Natural Biopolymers

Leonard Ionut Atanase

Summary: Micellar drug delivery systems based on natural biopolymers offer advantages such as compatibility, biodegradability, high drug loading, and passive accumulation, but their clinical use is not yet widespread.

POLYMERS (2021)

Article Chemistry, Multidisciplinary

Multi-Responsive Biodegradable Cationic Nanogels for Highly Efficient Treatment of Tumors

Xin Li et al.

Summary: In this study, intelligent cationic NGs with tunable responsiveness, versatility, and biodegradation are developed for precision medicine applications. By utilizing modular design and engineered strategy, NGs with different responsiveness and functionalities are prepared, including hybrid NGs with high photothermal conversion efficiency and drug release properties combined with photothermal-chemotherapy.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

Mechanochemical Release of Non-Covalently Bound Guests from a Polymer-Decorated Supramolecular Cage

Robin Kueng et al.

Summary: The supramolecular coordination cage within a star-shaped water-soluble polymer can respond to ultrasonication-induced shear force and release pharmaceutically active cargo encapsulated within its hydrophobic nanocavity.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Multidisciplinary

Mechanochemical Release of N-Heterocyclic Carbenes from Flex-Activated Mechanophores

Hang Shen et al.

Summary: A new flex-activated mechanophore has been discovered, which releases an N-heterocyclic carbene (NHC) under mechanical load. This design demonstrates a promising first step towards flex-activated designs with downstream reactivities, allowing for iterative activation increases in the material through non-destructive compression cycles. The potential modularity of the mechanophore design is highlighted by the demonstration of two different NHC structures.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Review Pharmacology & Pharmacy

Design of liposomes as drug delivery system for therapeutic applications

Diana Guimaraes et al.

Summary: Liposomes are effective drug delivery systems that improve therapeutic efficacy, being nontoxic and biodegradable. Key aspects such as design, production techniques, drug loading, and characterization for in vitro and in vivo performance are essential for successful liposomal formulations. Other topics explored include functionalization, targeting strategies, stability, limitations, and current market applications of liposomes in various therapeutic fields.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Review Chemistry, Multidisciplinary

Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions

M. Ghezzi et al.

Summary: Polymeric micelles, innovative aggregation colloids formed by self-assembling of amphiphilic polymers in solution, offer advantages in drug administration but also face challenges such as lower stability and complex characterization. Understanding their interaction with the biological environment is crucial, and a combination of different characterization techniques can provide a deeper insight into their in vivo behavior.

JOURNAL OF CONTROLLED RELEASE (2021)

Review Engineering, Biomedical

The evolution of commercial drug delivery technologies

Ava M. Vargason et al.

Summary: This review article discusses how challenges in delivering small molecules, nucleic acids, peptides, proteins, and cells have led to the development of commercial products and are now guiding the delivery of live-cell therapeutics. Drug delivery technologies have enabled the development of pharmaceutical products that enhance therapeutic delivery, minimize off-target effects, and improve patient compliance. Three drug delivery paradigms have been developed to aid in the successful delivery of small molecules and macromolecules, contributing to the initial clinical success of each therapeutic class.

NATURE BIOMEDICAL ENGINEERING (2021)

Article Chemistry, Multidisciplinary

Mechanically Triggered Release of Functionally Diverse Molecular Payloads from Masked 2-Furylcarbinol Derivatives

Xiaoran Hu et al.

Summary: A general mechanophore platform based on masked 2-furylcarbinol derivatives is described in this study, which can spontaneously decompose under mild conditions upon liberation via a mechanically triggered reaction, resulting in the release of functionally diverse molecular cargo with adjustable release kinetics. The platform demonstrates good selectivity and control, and efficient release of various cargo molecules can be triggered by ultrasound-induced mechanical force.

ACS CENTRAL SCIENCE (2021)

Article Chemistry, Multidisciplinary

5-Aryloxy substitution enables efficient mechanically triggered release from a synthetically accessible masked 2-furylcarbinol mechanophore

Tian Zeng et al.

Summary: In this study, a new mechanophore platform based on a masked 2-furylcarbinol derivative was reported, which efficiently releases phenol and arylamine payloads following mechanical activation. This platform incorporates a 5-aryloxy group as an electron-rich substituent to accelerate molecular release.

CHEMICAL COMMUNICATIONS (2021)

Article Chemistry, Multidisciplinary

Force-mediated molecule release from double network hydrogels

Pavithra Bhakthi Jayathilaka et al.

Summary: Incorporating mechanosensitive linkages into polymers produces materials with dynamic force responsivity. The oxanorbornadiene cross-linked double network hydrogels release molecules through a force-mediated retro Diels-Alder reaction. Activation at physiologically relevant forces enables dynamic mechanochemical behavior in soft biological materials.

CHEMICAL COMMUNICATIONS (2021)

Article Nanoscience & Nanotechnology

Molecular-Gated Drug Delivery Systems Using Light-Triggered Hydrophobic-to-Hydrophilic Switches

Mozhdeh Ghani et al.

Summary: This study designed and demonstrated a photoresponsive molecular-gated drug delivery system based on silicone-hydrogel interpenetrating polymer networks, utilizing spiropyran molecules as a switchable molecular gate triggered by light for on-demand drug release. The efficiency of the system was confirmed through comparison with a control group and analysis of structural changes caused by UV light.

ACS APPLIED BIO MATERIALS (2021)

Review Chemistry, Physical

Targeted liposomal drug delivery: a nanoscience and biophysical perspective

Yibo Liu et al.

Summary: Liposomes are a unique platform for drug delivery, with a focus on enhancing the targeting properties. The biophysical properties of lipids play a crucial role in both passive and active targeting of drug delivery systems. Research efforts are aimed at improving the targeting capabilities of liposomes.

NANOSCALE HORIZONS (2021)

Article Chemistry, Multidisciplinary

Mechanochemical activation of disulfide-based multifunctional polymers for theranostic drug release

Zhiyuan Shi et al.

Summary: A novel ultrasound-responsive release system has been developed to achieve spatiotemporal control over drug activity and enable real-time tracking of drug release and uptake, potentially useful for therapeutic applications and fluorescence imaging.

CHEMICAL SCIENCE (2021)

Article Chemistry, Multidisciplinary

A Latent Mechanoacid for Time-Stamped Mechanochromism and Chemical Signaling in Polymeric Materials

Yangju Lin et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Chemistry, Medicinal

On the Promise of Photopharmacology Using Photoswitches: A Medicinal Chemist's Perspective

Matthew J. Fuchter

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Clinical Neurology

A systematic review of ultrasound imaging and therapy in mental disorders

Marta Andrea Siragusa et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2020)

Article Chemistry, Multidisciplinary

Toward Drug Release Using Polymer Mechanochemical Disulfide Scission

Zhiyuan Shi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Editorial Material Polymer Science

Polymer Mechanochemistry and the Emergence of the Mechanophore Concept

Guillaume De Bo

MACROMOLECULES (2020)

Review Chemistry, Multidisciplinary

Design and Applications of Water-Soluble Coordination Cages

Edmundo G. Percastegui et al.

CHEMICAL REVIEWS (2020)

Article Biochemistry & Molecular Biology

The bright side of sound: perspectives on the biomedical application of sonoluminescence

Roberto Canaparo et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2020)

Review Polymer Science

Polymer mechanochemistry-enabled pericyclic reactions

Emilia Izak-Nau et al.

POLYMER CHEMISTRY (2020)

Review Multidisciplinary Sciences

Supramolecular nanoscale drug-delivery system with ordered structure

Xin Jin et al.

NATIONAL SCIENCE REVIEW (2019)

Article Nanoscience & Nanotechnology

Direct Evidence of Multibubble Sonoluminescence Using Therapeutic Ultrasound and Microbubbles

Estelle Beguin et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Review Chemistry, Multidisciplinary

Ultrasound and Sonochemistry for Radical Polymerization: Sound Synthesis

Thomas G. McKenzie et al.

CHEMISTRY-A EUROPEAN JOURNAL (2019)

Article Multidisciplinary Sciences

High-intensity focused ultrasound-induced mechanochemical transduction in synthetic elastomers

Gun Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Chemistry, Multidisciplinary

Mechanically Triggered Small Molecule Release from a Masked Furfuryl Carbonate

Xiaoran Hu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Review Biotechnology & Applied Microbiology

Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond

Priyanka Tharkar et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

Article Chemistry, Multidisciplinary

Anthracene-based mechanophores for compression-activated fluorescence in polymeric networks

Christopher P. Kabb et al.

CHEMICAL SCIENCE (2019)

Review Chemistry, Multidisciplinary

In Vivo Photopharmacology

Katharina Hull et al.

CHEMICAL REVIEWS (2018)

Review Chemistry, Multidisciplinary

Block Copolymer Micelles in Nanomedicine Applications

Horacio Cabral et al.

CHEMICAL REVIEWS (2018)

Review Nanoscience & Nanotechnology

Stimuli-responsive polymeric micelles for drug delivery and cancer therapy

Qing Zhou et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

Review Pharmacology & Pharmacy

A review on pH and temperature responsive gels and other less explored drug delivery systems

Pradeep Kumar Bolla et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2018)

Review Chemistry, Multidisciplinary

Polymer Mechanochemistry: Manufacturing Is Now a Force to Be Reckoned With

Niamh Willis-Fox et al.

Review Nanoscience & Nanotechnology

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Hossein Jahangirian et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

Article Multidisciplinary Sciences

Synthetic smart gel provides glucose-responsive insulin delivery in diabetic mice

Akira Matsumoto et al.

SCIENCE ADVANCES (2017)

Review Chemistry, Multidisciplinary

Steering chemical reactions with force

Sergi Garcia-Manyes et al.

NATURE REVIEWS CHEMISTRY (2017)

Article Engineering, Biomedical

An RGD-modified hollow silica@Au core/shell nanoplatform for tumor combination therapy

Xin Li et al.

ACTA BIOMATERIALIA (2017)

Article Nanoscience & Nanotechnology

Formation of Gold Nanostar-Coated Hollow Mesoporous Silica for Tumor Multimodality Imaging and Photothermal Therapy

Xin Li et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Review Pharmacology & Pharmacy

Recent advances in light-responsive on-demand drug- delivery systems

Chase S. Linsley et al.

THERAPEUTIC DELIVERY (2017)

Article Chemistry, Multidisciplinary

Emerging Targets in Photopharmacology

Michael M. Lerch et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Review Chemistry, Multidisciplinary

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

Mahdi Karimi et al.

CHEMICAL SOCIETY REVIEWS (2016)

Article Chemistry, Multidisciplinary

Sonoporation enhances liposome accumulation and penetration in tumors with low EPR

Benjamin Theek et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Article Chemistry, Multidisciplinary

Mechanogeneration of Acid from Oxime Sulfonates

Chikkannagari Nagamani et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

Review Chemistry, Multidisciplinary

Emerging Frontiers in Drug Delivery

Mark W. Tibbitt et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

Review Nanoscience & Nanotechnology

Designing hydrogels for controlled drug delivery

Jianyu Li et al.

NATURE REVIEWS MATERIALS (2016)

Review Chemistry, Multidisciplinary

Polymer Mechanochemistry: From Destructive to Productive

Jun Li et al.

ACCOUNTS OF CHEMICAL RESEARCH (2015)

Review Chemistry, Multidisciplinary

A Roadmap to Success in Photopharmacology

Johannes Broichhagen et al.

ACCOUNTS OF CHEMICAL RESEARCH (2015)

Review Chemistry, Multidisciplinary

New Developments in Liposomal Drug Delivery

Bhushan S. Pattni et al.

CHEMICAL REVIEWS (2015)

Article Radiology, Nuclear Medicine & Medical Imaging

Ultrasound molecular imaging: Moving toward clinical translation

Lotfi Abou-Elkacem et al.

EUROPEAN JOURNAL OF RADIOLOGY (2015)

Review Pharmacology & Pharmacy

Advances and Challenges of Liposome Assisted Drug Delivery

Lisa Sercombe et al.

FRONTIERS IN PHARMACOLOGY (2015)

Review Pharmacology & Pharmacy

Evolution of contrast agents for ultrasound imaging and ultrasound-mediated drug delivery

Vera Paefgen et al.

FRONTIERS IN PHARMACOLOGY (2015)

Review Pharmacology & Pharmacy

The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes

Salma E. Ahmed et al.

JOURNAL OF DRUG TARGETING (2015)

Review Pharmacology & Pharmacy

Recent advances in molecular, multimodal and theranostic ultrasound imaging

Fabian Kiessling et al.

ADVANCED DRUG DELIVERY REVIEWS (2014)

Review Pharmacology & Pharmacy

Nucleic acid delivery with microbubbles and ultrasound

Joshua J. Rychak et al.

ADVANCED DRUG DELIVERY REVIEWS (2014)

Review Pharmacology & Pharmacy

High Intensity Focused Ultrasound Technology, Its Scope and Applications in Therapy and Drug Delivery

Christopher P. Phenix et al.

JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (2014)

Article Chemistry, Multidisciplinary

Mechanophore Activation at Heterointerfaces

Jun Li et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Chemistry, Multidisciplinary

Successive Mechanochemical Activation and Small Molecule Release in an Elastomeric Material

Michael B. Larsen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Chemistry, Multidisciplinary

Photopharmacology: Beyond Proof of Principle

Willem A. Velema et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

News Item Chemistry, Multidisciplinary

POLYMER MECHANOCHEMISTRY Flex, release and repeat

Nancy R. Sottos

NATURE CHEMISTRY (2014)

Review Chemistry, Multidisciplinary

Polymeric micelles as drug delivery vehicles

Zaheer Ahmad et al.

RSC ADVANCES (2014)

Review Pharmacology & Pharmacy

Multifunctional polymeric micelles for delivery of drugs and siRNA

Aditi M. Jhaveri et al.

FRONTIERS IN PHARMACOLOGY (2014)

Review Pharmacology & Pharmacy

Multidrug resistance: Physiological principles and nanomedical solutions

Sijumon Kunjachan et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

Article Biochemistry & Molecular Biology

In Vivo Biodistribution of Mixed Shell Micelles with Tunable Hydrophilic/Hydrophobic Surface

Hongjun Gao et al.

BIOMACROMOLECULES (2013)

Review Chemistry, Multidisciplinary

On the mechanochemical activation by ultrasound

Giancarlo Cravotto et al.

CHEMICAL SOCIETY REVIEWS (2013)

Review Chemistry, Multidisciplinary

Polymer mechanochemistry: techniques to generate molecular force via elongational flows

Preston A. May et al.

CHEMICAL SOCIETY REVIEWS (2013)

Article Chemistry, Multidisciplinary

Flex-Activated Mechanophores: Using Polymer Mechanochemistry To Direct Bond Bending Activation

Michael B. Larsen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Review Chemistry, Physical

Stimuli-responsive nanocarriers for drug delivery

Simona Mura et al.

NATURE MATERIALS (2013)

Review Polymer Science

Polymer mechanochemistry: the design and study of mechanophores

Johnathan N. Brantley et al.

POLYMER INTERNATIONAL (2013)

Article Health Care Sciences & Services

Ultrasound-Mediated Drug/Gene Delivery in Solid Tumor Treatment

Yufeng Zhou

JOURNAL OF HEALTHCARE ENGINEERING (2013)

Review Oncology

Clinical and future applications of high intensity focused ultrasound in cancer

Osama Al-Bataineh et al.

CANCER TREATMENT REVIEWS (2012)

Article Oncology

Use of ultrasound in drug delivery systems: emphasis on experimental methodology and mechanisms

Loreto B. Feril et al.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2012)

Article Oncology

Ultrasound-mediated micellar drug delivery

Natalya Rapoport

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2012)

Article Chemistry, Multidisciplinary

Image-guided, targeted and triggered drug delivery to tumors using polymer-based microbubbles

Stanley Fokong et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Article Radiology, Nuclear Medicine & Medical Imaging

Ultrasound Microbubbles for Molecular Diagnosis, Therapy, and Theranostics

Fabian Kiessling et al.

JOURNAL OF NUCLEAR MEDICINE (2012)

Review Chemistry, Medicinal

Molecular Nanomedicine Towards Cancer: 111In-Labeled Nanoparticles

Dimitrios Psimadas et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2012)

Article Chemistry, Multidisciplinary

Proton-Coupled Mechanochemical Transduction: A Mechanogenerated Add

Charles E. Diesendruck et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Chemistry, Physical

Mechano-responsive hydrogels crosslinked by block copolymer micelles

Longxi Xiao et al.

SOFT MATTER (2012)

Review Nanoscience & Nanotechnology

Phase-shift, stimuli-responsive perfluorocarbon nanodroplets for drug delivery to cancer

Natalya Rapoport

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2012)

Review Pharmacology & Pharmacy

Drug delivery systems: An updated review

Gaurav Tiwari et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION (2012)

Article Chemistry, Multidisciplinary

Nanobubbles from Gas-Generating Polymeric Nanoparticles: Ultrasound Imaging of Living Subjects

Eunah Kang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

Article Chemistry, Multidisciplinary

High intensity focused ultrasound and redox dual responsive polymer micelles

Yongwen Li et al.

CHEMICAL COMMUNICATIONS (2010)

Review Biochemistry & Molecular Biology

Age-Related Pharmacokinetic and Pharmacodynamic Changes and Related Risk of Adverse Drug Reactions

A. Corsonello et al.

CURRENT MEDICINAL CHEMISTRY (2010)

Review Chemistry, Multidisciplinary

Mechanically-Induced Chemical Changes in Polymeric Materials

Mary M. Caruso et al.

CHEMICAL REVIEWS (2009)

Review Biochemistry & Molecular Biology

Functional and Molecular Ultrasound Imaging: Concepts and Contrast Agents

F. Kiessling et al.

CURRENT MEDICINAL CHEMISTRY (2009)

Article Chemistry, Multidisciplinary

Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles

Natalya Y. Rapoport et al.

JOURNAL OF CONTROLLED RELEASE (2009)

Review Chemistry, Medicinal

Ultrasonic-Activated Micellar Drug Delivery for Cancer Treatment

Ghaleb A. Husseini et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2009)

Article Chemistry, Multidisciplinary

Activating catalysts with mechanical force

Alessio Piermattei et al.

NATURE CHEMISTRY (2009)

Article Oncology

Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy

Natalya Rapoport et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2007)

Article Biotechnology & Applied Microbiology

Innovation - Healing sound: the use of ultrasound in drug delivery and other therapeutic applications

S Mitragotri

NATURE REVIEWS DRUG DISCOVERY (2005)

Article Chemistry, Multidisciplinary

Mechanism of the ultrasonic activation of micellar drug delivery

A Marin et al.

JOURNAL OF CONTROLLED RELEASE (2001)

Article Multidisciplinary Sciences

Controlled growth factor release from synthetic extracellular matrices

KY Lee et al.

NATURE (2000)