☆ 4.6 Article

Understanding basic multicellular unit activity in cortical bone through 3D morphological analysis: New methods to define zones of the remodeling space

BONE (2024)

Related references

Note: Only part of the references are listed.

Article Endocrinology & Metabolism

Local coordination between intracortical bone remodeling and vascular development in human juvenile bone

Christina Moller Andreasen et al.

Summary: This study reveals the association between bone resorption events and vascular development. Analysis of proximal femoral cortical bone showed that vessels were more prevalent in non-quiescent pores compared to quiescent pores. Remodeling of existing pores had a higher density of vessels compared to de novo created pores. Additionally, pores at the eroded-formative remodeling stage had the highest density of vessels. Through 3D reconstruction, it was found that osteoclasts in the cutting cone and preosteoclasts in the lumen expressed VEGFA, while VEGFA-receptors were mainly expressed in endothelial cells in the adjacent vasculature. Therefore, it is proposed that the progression of the vascular network in intracortical remodeling events is driven by osteoclasts expressing VEGFA, and the vasculature is continuously reconfigured according to the demands of the remodeling events at the surrounding bone surfaces.

BONE (2023)

Add to Collection

Article Endocrinology & Metabolism

Daily administration of parathyroid hormone slows the progression of basic multicellular units in the cortical bone of the rabbit distal tibia

David M. L. Cooper et al.

Summary: This study aimed to investigate the effects of PTH on bone remodeling. The results showed that PTH not only increased the initiation rate of cortical BMUs but also slowed down their progression. However, the anabolic effect of PTH on bone formation was sustained even after withdrawal. These findings suggest the potential utility of PTH in optimizing clinical dosing regimens.

BONE (2023)

Add to Collection

Article Endocrinology & Metabolism

Direct Assessment of Rabbit Cortical Bone Basic Multicellular Unit Longitudinal Erosion Rate: A 4D Synchrotron-Based Approach

Kim D. Harrison et al.

Summary: In this study, a 4D in vivo method was used to directly measure the longitudinal erosion rate (LER) for studying the spatiotemporal coordination of bone remodeling and its role in diseases such as osteoporosis. The method involved synchrotron imaging of rabbit tibias in vivo and ex vivo, and the average LER was determined.

JOURNAL OF BONE AND MINERAL RESEARCH (2022)

Add to Collection

Article Cell & Tissue Engineering

TOWARDS NOVEL MEASUREMENTS OF REMODELLING ACTIVITY IN CORTICAL BONE: IMPLICATIONS FOR OSTEOPOROSIS AND RELATED PHARMACEUTICAL TREATMENTS

L. L. Loundagin et al.

Summary: Abnormal changes in BMU activity can lead to osteoporosis. This review examines the alterations in BMU activity in various conditions and the impact of pharmaceutical treatments. The regulation of BMU activity and the dynamics of remodelling, particularly in cortical bone, are still poorly understood. Recent advances in imaging technology provide opportunities for studying cortical bone remodelling in vivo.

EUROPEAN CELLS & MATERIALS (2022)

Add to Collection

Article Anatomy & Morphology

Quantifying intracortical bone microstructure: A critical appraisal of 2D and 3D approaches for assessing vascular canals and osteocyte lacunae

Katherine A. Williams et al.

Summary: Describing and quantifying vascular canal orientation and volume of osteocyte lacunae in bone is crucial for studies on bone growth, mechanics, health, and disease. Recent 3D methods show promise for a more accurate approach, but further investigation is needed to compare with traditional 2D methods.

JOURNAL OF ANATOMY (2021)

Add to Collection

Article Engineering, Biomedical

Anatomical variation in intracortical canal network microarchitecture and its influence on bone fracture risk

Piyush Uniyal et al.

Summary: Intracortical canals significantly contribute to cortical bone porosity and mechanical response, with canal networks acting as stress concentrators. Site-dependent variations were found in canal porosity, orientation, and length, with the lateral cortex exhibiting significantly higher porosity compared to the posterior cortex. The study suggests that canal orientation and porosity play a significant role in bone fracture risk assessment.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2021)

Add to Collection

Article Endocrinology & Metabolism

Cortical Bone Porosity in Rabbit Models of Osteoporosis

Kim D. Harrison et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2020)

Add to Collection

Article Psychology, Social

Taking Parametric Assumptions Seriously: Arguments for the Use of Welch's F-test instead of the Classical F-test in One-Way ANOVA

Marie Delacre et al.

INTERNATIONAL REVIEW OF SOCIAL PSYCHOLOGY (2019)

Add to Collection

Article Endocrinology & Metabolism

The effects of estrogen deficiency on cortical bone microporosity and mineralization

Divya Sharma et al.

BONE (2018)

Add to Collection

Article Anatomy & Morphology

Interpreting the three-dimensional orientation of vascular canals and cross-sectional geometry of cortical bone in birds and bats

Isaac V. Pratt et al.

JOURNAL OF ANATOMY (2018)

Add to Collection

Article Endocrinology & Metabolism

Understanding Age-Induced Cortical Porosity in Women: The Accumulation and Coalescence of Eroded Cavities Upon Existing Intracortical Canals Is the Main Contributor

Christina Moller Andreasen et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2018)

Add to Collection

Article Endocrinology & Metabolism

Effects of Long-Term Denosumab on Bone Histomorphometry and Mineralization in Women With Postmenopausal Osteoporosis

David W. Dempster et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2018)

Add to Collection

Article Endocrinology & Metabolism

Coupling of Bone Resorption and Formation in Real Time: New Knowledge Gained From Human Haversian BMUs

Nicolai Ernlund Lassen et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2017)

Add to Collection

Article Microscopy

A method for measuring the three-dimensional orientation of cortical canals with implications for comparative analysis of bone microstructure in vertebrates

Isaac Vorster Pratt et al.

MICRON (2017)

Add to Collection

Article Pharmacology & Pharmacy

Plasma concentrations and sedative effects of a dexmedetomidine, midazolam, and butorphanol combination after transnasal administration in healthy rabbits

B. Santangelo et al.

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS (2016)

Add to Collection

Article Rehabilitation

A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research

Terry K. Koo et al.

JOURNAL OF CHIROPRACTIC MEDICINE (2016)

Add to Collection

Article Endocrinology & Metabolism

A reversal phase arrest uncoupling the bone formation and resorption contributes to the bone loss in glucocorticoid treated ovariectomised aged sheep

Christina M. Andreasen et al.

BONE (2015)

Add to Collection

Article Endocrinology & Metabolism

A joined role of canopy and reversal cells in bone remodeling - Lessons from glucocorticoid-induced osteoporosis

Pia Rosgaard Jensen et al.

BONE (2015)

Add to Collection

Article Endocrinology & Metabolism

Regional Heterogeneity in the Configuration of the Intracortical Canals of the Femoral Shaft

Egon Perilli et al.

CALCIFIED TISSUE INTERNATIONAL (2015)

Add to Collection

Article Anatomy & Morphology

Does 3D orientation account for variation in osteon morphology assessed by 2D histology?

Cheryl Hennig et al.

JOURNAL OF ANATOMY (2015)

Add to Collection

Article Endocrinology & Metabolism

Effects of Denosumab, Alendronate, or Denosumab Following Alendronate on Bone Turnover, Calcium Homeostasis, Bone Mass and Bone Strength in Ovariectomized Cynomolgus Monkeys

Paul J. Kostenuik et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2015)

Add to Collection

Article Anatomy & Morphology

Visualization of 3D osteon morphology by synchrotron radiation micro-CT

D. M. L. Cooper et al.

JOURNAL OF ANATOMY (2011)

Add to Collection

Article Endocrinology & Metabolism

BoneJ Free and extensible bone image analysis in ImageJ

Michael Doube et al.

BONE (2010)

Add to Collection

Article Endocrinology & Metabolism

Effects of Denosumab on Bone Histomorphometry: The FREEDOM and STAND Studies

Ian R. Reid et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2010)

Add to Collection

Article Biophysics

In vivo micro-CT scanning of a rabbit distal femur: Repeatability and reproducibility

Michael J. Voor et al.

JOURNAL OF BIOMECHANICS (2008)

Add to Collection

Article Veterinary Sciences

Sex-related variation in compact bone microstructure of the femoral diaphysis in juvenile rabbits

Monika Martiniakova et al.

ACTA VETERINARIA SCANDINAVICA (2008)

Add to Collection

Article Anthropology

Histological study of compact bone tissue in some mammals: A method for species determination

M. Martiniakova et al.

INTERNATIONAL JOURNAL OF OSTEOARCHAEOLOGY (2007)

Add to Collection

Article Orthopedics

Three-dimensional characterization of cortical bone microstructure by microcomputed tomography: validation with ultrasonic and microscopic measurements

Armelle Basillais et al.

JOURNAL OF ORTHOPAEDIC SCIENCE (2007)

Add to Collection

Article Anatomy & Morphology

Three-dimensional microcomputed tomography imaging of basic multicellular unit-related resorption spaces in human cortical bone

David M. L. Cooper et al.

ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY (2006)

Add to Collection

© Peeref 2019-2024. All rights reserved.