4.7 Article

Environment-triggered nanoagent with programmed gas release performance for accelerating diabetic infected wound healing

Related references

Note: Only part of the references are listed.
Review Chemistry, Multidisciplinary

Recent Nanotechnologies to Overcome the Bacterial Biofilm Matrix Barriers

Xinyi Lv et al.

Summary: Bacterial biofilm-related infectious diseases have a severe impact on human health. The low permeability and enrichment of therapeutic agents within the biofilm pose a challenge for treatment. This article summarizes the current progress in nanotechnology methods to improve the penetrability of therapeutic agents and discusses the challenges and future implementations of engineered delivery systems to manage biofilm infections.

SMALL (2023)

Review Chemistry, Multidisciplinary

Microenvironment-Based Diabetic Foot Ulcer Nanomedicine

Fang Huang et al.

Summary: Diabetic foot ulcers (DFU) are one of the most serious complications of diabetes, characterized by chronic, nonhealing wounds caused by diabetic neuropathy, vascular disease, and bacterial infection. Current clinical therapies for DFU are unsatisfactory, leading researchers to focus on advanced nanotechnology. The development of multifunctional nanosystems based on the microenvironment of DFU has shown positive effects in therapy, forming a novel concept of DFU nanomedicine.

ADVANCED SCIENCE (2023)

Article Chemistry, Multidisciplinary

Infected Diabetic Wound Regeneration Using Peptide-Modified Chiral Dressing to Target Revascularization

Chao Xing et al.

Summary: By reducing AGEs selectively and killing multidrug-resistant bacteria, the HA-LM2-RMR gel promotes the healing of diabetic wounds. Compared to Prontosan Wound Gel, the HA-LM2-RMR gel shows better therapeutic effects in promoting angiogenesis and re-epithelialization, shortening the healing time from 21 days to 14 days.

ACS NANO (2023)

Article Chemistry, Multidisciplinary

A Magnetic Cloud Bomb for Effective Biofilm Eradication

Yuping Qian et al.

Summary: Researchers have synthesized a magnetic nano-cloud bomb, ZIF-L-Fe, which has a flower-like clustered structure with sharp edges. This structure enhances the dispersion of Fe nanoparticles and increases biofilm penetration under the action of magnetism, resulting in the destruction of the biofilm structure. This novel concept provides a potential treatment strategy for biofilm infections.

ADVANCED FUNCTIONAL MATERIALS (2023)

Review Biochemistry & Molecular Biology

Biological macromolecules-based nanoformulation in improving wound healing and bacterial biofilm-associated infection: A review

Sourbh Suren Garg et al.

Summary: Chronic wounds in diabetes mellitus patients are difficult to heal due to high glucose levels, oxidative stress, and biofilm-associated microbial infection. Conventional antibiotic therapies are ineffective in clinical settings as antibiotics cannot penetrate the microbial biofilm matrix. Therefore, finding safer alternatives to reduce chronic wound infection is urgently needed. Using biological-macromolecule based nano-delivery systems to inhibit biofilm formation offers advantages such as higher drug loading efficiency, sustained drug release, enhanced drug stability, and improved bioavailability. This review discusses the pathogenesis, microbial biofilm formation, and immune response of chronic wounds, as well as the potential of macromolecule-based nanoparticles as wound healing therapies to reduce mortality associated with chronic wound infections.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

Article Engineering, Environmental

H2S-releasing versatile hydrogel dressing with potent antimicrobial, anti-inflammatory, epithelialization and angiogenic capabilities for diabetic wound healing

Jiale Chen et al.

Summary: A smart hydrogel dressing capable of highly effective antimicrobial, anti-inflammatory, and promoting wound healing properties was developed using a Schiff base reaction between carboxymethyl chitosan (CMC) and polyhexamethylene guanidine (PHMG)-modified aldehyde F108 (PFC). The hydrogel released H2S and utilized the synergistic effect of DATS and PHMG to provide antimicrobial and anti-inflammatory effects. Additionally, the hydrogel promoted proliferation, migration, and vascularization of endothelial cells through the activation of p-p38 and p-ERK1/2. This study highlights the potential of the hydrogel for managing diabetic wounds.

CHEMICAL ENGINEERING JOURNAL (2023)

Article Engineering, Biomedical

Nitric Oxide-Assisted Photodynamic Therapy for Enhanced Penetration and Hypoxic Bacterial Biofilm Elimination

Xinyi Lv et al.

Summary: A phototherapeutic nanoagent that releases nitric oxide (NO) has been developed to overcome biofilm-associated infections. Under laser irradiation, the nanoagent releases NO, enhances biofilm permeability, and generates reactive oxygen species (ROS) to effectively eliminate biofilm infections. It also stimulates collagen deposition and promotes angiogenesis in vivo.

ADVANCED HEALTHCARE MATERIALS (2023)

Article Engineering, Biomedical

Nanotherapeutics with immunoregulatory functions for the treatment of bacterial infection

Dongliang Yang et al.

Biomaterials Research (2023)

Review Materials Science, Biomaterials

Recent progress in nanozymes for the treatment of diabetic wounds

Jingai Jiang et al.

Summary: The slow healing of diabetic wounds has negatively impacted human health, and open wounds are prone to bacterial infection. Clinical methods such as antibiotic therapy, insulin treatment, and surgical debridement have been successful in treating diabetic wounds, but long-term antibiotic use leads to drug-resistant bacteria and decreased efficacy. Developing novel therapeutic strategies is crucial in effectively promoting diabetic wound healing.

JOURNAL OF MATERIALS CHEMISTRY B (2023)

Article Medicine, Research & Experimental

Near-infrared light-triggered nitric oxide nanocomposites for photodynamic/photothermal complementary therapy against periodontal biofilm in an animal model

Xiangrong Wu et al.

Summary: Researchers have developed a novel nanocomposite with synergistic photothermal and photodynamic therapy using NO gas. This material shows promising therapeutic effects in treating deep tissue biofilm infections and provides a new solution for other biofilm infection diseases.

THERANOSTICS (2023)

Article Chemistry, Multidisciplinary

Infected Diabetic Wound Regeneration Using Peptide-Modified Chiral Dressing to Target Revascularization

Chao Xing et al.

Summary: In this study, a designed chiral gel dressing (HA-LM2-RMR) showed superior healing efficiency in infected diabetic wounds by promoting angiogenesis and re-epithelialization. The gel interacted selectively with AGEs and multidrug resistant bacteria, leading to enhanced wound healing compared to traditional wound gels.

ACS NANO (2023)

Article Materials Science, Multidisciplinary

Bamboo-Inspired Gasotransmitter Microfibres for Wound Healing

Cheng Zhao et al.

Summary: In this study, bamboo-inspired gasotransmitter microfibres were generated using microfluidic spinning, allowing for precise control of bubble size and morphology. The microfibres promoted wound healing through the dual effects of drugs and gas, and the addition of responsive materials enabled controlled drug release for continuous effects.

ADVANCED FIBER MATERIALS (2023)

Article Engineering, Multidisciplinary

Engineered multifunctional nanocomposite hydrogel dressing to promote vascularization and anti-inflammation by sustained releasing of Mg2+ for diabetic wounds

Shuangli Zhu et al.

Summary: Diabetic ulcers are common and severe chronic wounds that are difficult to treat due to the risk of deep wound bacterial infection and lack of bioactivity for rapid wound repair. A bioactive hydrogel dressing with self-adaptation was developed in this study, showing promising results in accelerating wound healing, promoting vascularization, and reducing inflammation in diabetic wounds.

COMPOSITES PART B-ENGINEERING (2022)

Review Chemistry, Multidisciplinary

The management of diabetes mellitus by mangiferin: advances and prospects

Mengdi Wang et al.

Summary: Mangiferin, a polyphenol and natural product, shows potential effects in treating diabetes mellitus and its complications. However, its limited solubility requires modification in dosage form to improve bioavailability.

NANOSCALE (2022)

Review Microbiology

Tolerance and resistance of microbial biofilms

Oana Ciofu et al.

Summary: Chronic infections caused by microbial biofilms pose a significant clinical challenge due to the resistance of biofilms to antimicrobials and the immune system, leading to persistent and recurrent infections. This Review discusses the current understanding of the mechanisms underlying the tolerance of biofilms to the immune system and to antimicrobials, as well as their role in the development of antimicrobial resistance.

NATURE REVIEWS MICROBIOLOGY (2022)

Article Chemistry, Multidisciplinary

Recent advances in upconversion nanoparticle-based nanocomposites for gas therapy

Nailin Yang et al.

Summary: Gas therapy using upconversion nanoparticles (UCNPs) for controlled gas release has shown great promise in various medical applications, such as cancer therapy and bacterial therapy. The unique upconversion luminescence (UCL) ability of UCNPs enables the conversion of long wavelength light to ultraviolet/visible (UV/Vis) light for precise gas release. Further research and development in this area are needed to explore the full potential of UCNP-based nanocomposites in gas therapy.

CHEMICAL SCIENCE (2022)

Article Nanoscience & Nanotechnology

Targeted Polymeric Nanoparticles Based on Mangiferin for Enhanced Protection of Pancreatic β-Cells and Type 1 Diabetes Mellitus Efficacy

Mengdi Wang et al.

Summary: This study developed targeted nanoparticles for efficient delivery of Mangiferin (MGF) to the pancreas, resulting in improved accumulation, hypoglycemic effect, and restorative effects on pancreatic islets. Compared to free MGF, the nanoparticles showed enhanced concentration in the pancreas, better blood glucose control, increased insulin levels, and improved pancreatic islet repair.

ACS APPLIED MATERIALS & INTERFACES (2022)

Article Engineering, Biomedical

An injectable and biodegradable hydrogel incorporated with photoregulated NO generators to heal MRSA-infected wounds

Xinyi Lv et al.

Summary: An injectable, degradable, and photoactivated antibacterial hydrogel (MPDA-BNN6@Gel) was developed for the treatment of infected wounds. The hydrogel could generate local hyperthermia and release large quantities of NO gas to treat the infection under laser irradiation. It was found that the hydrogel eradicated bacteria by damaging the cell membrane, genetic metabolism, and material energy. Additionally, the hydrogel promoted wound healing in vivo in the absence of laser irradiation.

ACTA BIOMATERIALIA (2022)

Article Chemistry, Physical

Designed formation of Prussian Blue/CuS Janus nanostructure with enhanced NIR-I and NIR-II dual window response for tumor thermotherapy

Dan Li et al.

Summary: This study develops novel PB@PAA/CuS Janus nanoparticles with enhanced photothermal conversion efficiency, demonstrating enhanced absorption capabilities and deep tissue penetration in the NIR-I and NIR-II dual windows.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

Article Pharmacology & Pharmacy

Advances in intelligent-responsive nanocarriers for cancer therapy

Mingce Tian et al.

Summary: With the rapid development of nanotechnology, strategies related to nanomedicine have been utilized to overcome the drawbacks of traditional chemotherapy drugs, demonstrating potential for innovative drug delivery. Stimuli-responsive nanomaterials allow precise control of drug release and exhibit excellent specificity in response to various stimuli. Immunomodulators carried by nanomaterials can effectively regulate the immune system and enhance therapeutic effects on cancer.

PHARMACOLOGICAL RESEARCH (2022)

Article Multidisciplinary Sciences

Bioresponsive nano-antibacterials for H2S-sensitized hyperthermia and immunomodulation against refractory implant-related infections

Zheng Su et al.

Summary: There is a growing demand for nonantibiotic strategies to overcome drug resistance in bacterial biofilm infections. This study proposes a gas-sensitized hyperthermia strategy using a metal-organic framework (MOF)-sealed Prussian blue-based nanocarrier for efficient elimination of biofilms through H2S-induced thermal eradiation.

SCIENCE ADVANCES (2022)

Article Multidisciplinary Sciences

Potentiating hypoxic microenvironment for antibiotic activation by photodynamic therapy to combat bacterial biofilm infections

Weijun Xiu et al.

Summary: Traditional antibiotic treatment is not very effective against bacteria in biofilms due to their unique metabolic conditions. This study explores the use of photodynamic therapy to eliminate methicillin-resistant Staphylococcus aureus biofilms and enhance the hypoxic microenvironment, which induces anaerobic metabolism and activates the antibacterial activity of metronidazole. Additionally, the activated chemotherapy can promote the repair of biofilm-infected wounds by polarizing macrophages to a specific phenotype.

NATURE COMMUNICATIONS (2022)

Article Materials Science, Biomaterials

Hypothermia-Triggered Mesoporous Silica Particles for Controlled Release of Hydrogen Sulfide to Reduce the I/R Injury of the Myocardium

Wenyi Xia et al.

Summary: In this study, a new method for controlled release of hydrogen sulfide (H2S) was developed by coating temperature-sensitive polymer on mesoporous silica nanoparticles. The released H2S from these particles showed protective effects against ischemic and reperfusion injury in cardiomyocytes, as well as reduced inflammatory response. This study provides a promising approach for myocardial protection and controlled release of H2S.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

Review Chemistry, Multidisciplinary

Biofilm microenvironment-responsive nanoparticles for the treatment of bacterial infection

Yanling Hu et al.

Summary: Biofilm infectious diseases have become a growing global health issue, and conventional antibiotic therapy is ineffective due to poor biofilm penetration and antibiotic tolerance. The development of biofilm microenvironment-responsive nanoparticles offers a promising strategy for combating biofilm infection.

NANO TODAY (2022)

Review Chemistry, Multidisciplinary

Stimuli-responsive therapeutic systems for the treatment of diabetic infected wounds

Yanling Hu et al.

Summary: Diabetic wound infection is a common disease that poses challenges due to the diabetic wound environment and bacterial resistance. Nanobiomaterial-based therapeutic systems with stimuli-responsive performance can address these challenges by delivering therapeutic agents on demand.

NANOSCALE (2022)

Article Materials Science, Biomaterials

Preparation of exosomes encapsulated nanohydrogel for accelerating wound healing of diabetic rats by promoting angiogenesis

Yiyao Zhang et al.

Summary: The study showed that exosomes derived from HUCMSCs encapsulated in a nanohydrogel could promote proliferation, migration, and angiogenesis of endothelial cells, as well as accelerate diabetic wound healing. The nanohydrogel also upregulated the expression of wound healing-related molecules and increased VEGF levels through the ERK1/2 pathway, significantly enhancing the healing of diabetic wounds in rats by promoting angiogenesis.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Review Biotechnology & Applied Microbiology

Near-infrared light-triggered nano-prodrug for cancer gas therapy

Runcong Liu et al.

Summary: Gas therapy as a new cancer treatment method has gained increasing attention in recent years. By using near-infrared light as a stimulus to trigger the release of gas molecules, it has achieved improved therapeutic efficacy and reduced side effects.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Article Chemistry, Multidisciplinary

Engineering Bioactive M2 Macrophage-Polarized Anti-Inflammatory, Antioxidant, and Antibacterial Scaffolds for Rapid Angiogenesis and Diabetic Wound Repair

Zhuolong Tu et al.

Summary: A conductive hydrogel scaffold with M2 phenotype-enabled properties has been developed to enhance diabetic wound repair by promoting anti-inflammation and antioxidant activities.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

A Tumor-Microenvironment-Responsive Nanocomposite for Hydrogen Sulfide Gas and Trimodal-Enhanced Enzyme Dynamic Therapy

Bin Liu et al.

Summary: A rapidly decomposing nanocomposite was designed in this study to improve the efficiency of enzyme dynamic therapy, enhancing tumor therapy through multiple pathways and developing a new treatment strategy.

ADVANCED MATERIALS (2021)

Article Engineering, Environmental

Surfactin-reinforced gelatin methacrylate hydrogel accelerates diabetic wound healing by regulating the macrophage polarization and promoting angiogenesis

Lu Yan et al.

Summary: The newly developed hydrogel shows great potential in treating chronic wounds of diabetic patients by regulating macrophage polarization and promoting angiogenesis.

CHEMICAL ENGINEERING JOURNAL (2021)

Article Chemistry, Multidisciplinary

A naphthalimide-based peptide conjugate for concurrent imaging and apoptosis induction in cancer cells by utilizing endogenous hydrogen sulfide

Narendra Singh et al.

Summary: The excessive production of endogenous hydrogen sulfide in cancer cells promotes tumor growth, while decreased endogenous H2S suppresses tumor growth. A highly sensitive endogenous H2S responsive fluorescent probe was synthesized to selectively inhibit the proliferation of cancer cells through inducing apoptosis, as well as suppressing glycolytic reserve, and decreasing Young's modulus of cancer cells compared to control cells.

CHEMICAL SCIENCE (2021)

Review Multidisciplinary Sciences

Strategies for engineering advanced nanomedicines for gas therapy of cancer

Yingshuai Wang et al.

NATIONAL SCIENCE REVIEW (2020)

Article Nanoscience & Nanotechnology

Nitric Oxide-Releasing Insert for Disinfecting the Hub Region of Tunnel Dialysis Catheters

Joshua C. Doverspike et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Review Chemistry, Inorganic & Nuclear

Multifunctional Prussian blue-based nanomaterials: Preparation, modification, and theranostic applications

Xianwen Wang et al.

COORDINATION CHEMISTRY REVIEWS (2020)

Review Pharmacology & Pharmacy

Drug therapies and delivery mechanisms to treat perturbed skin wound healing

Jiah Shin Chin et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

Review Pharmacology & Pharmacy

In situ forming injectable hydrogels for drug delivery and wound repair

Robert Dimatteo et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Review Pharmacology & Pharmacy

Insights into the key roles of epigenetics in matrix macromolecules-associated wound healing

Zoi Piperigkou et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Review Chemistry, Multidisciplinary

Development of endogenous enzyme-responsive nanomaterials for theranostics

Jing Mu et al.

CHEMICAL SOCIETY REVIEWS (2018)

Article Polymer Science

Conjugated Polymer Nanoparticles with Aggregation Induced Emission Characteristics for Intracellular Fe3+ Sensing

Dongliang Yang et al.

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY (2016)

Article Nanoscience & Nanotechnology

Role of Size and Shape on Biofilm Eradication for Nitric Oxide-Releasing Silica Nanoparticles

Danielle L. Slomberg et al.

ACS APPLIED MATERIALS & INTERFACES (2013)

Article Biochemical Research Methods

Analysis of GSH and GSSG after derivatization with N-ethylmaleimide

Daniela Giustarini et al.

NATURE PROTOCOLS (2013)

Article Biochemistry & Molecular Biology

Making and working with hydrogen sulfide The chemistry and generation of hydrogen sulfide in vitro and its measurement in vivo: A review

Martin N. Hughes et al.

FREE RADICAL BIOLOGY AND MEDICINE (2009)

Article Gastroenterology & Hepatology

Endogenous and Exogenous Hydrogen Sulfide Promotes Resolution of Colitis in Rats

John L. Wallace et al.

GASTROENTEROLOGY (2009)

Article Multidisciplinary Sciences

Hydrogen sulfide is an endogenous stimulator of angiogenesis

Andreas Papapetropoulos et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biotechnology & Applied Microbiology

Nitric oxide-mediated dispersal in single- and multi-species biofilms of clinically and industrially relevant microorganisms

Nicolas Barraud et al.

MICROBIAL BIOTECHNOLOGY (2009)

Article Endocrinology & Metabolism

Advanced glycation end products and diabetic foot disease

Maya S. P. Huijberts et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2008)

Review Oncology

Cellular and molecular facets of keratinocyte reepithelization during wound healing

MM Santoro et al.

EXPERIMENTAL CELL RESEARCH (2005)