Journal
JOURNAL OF FLOW CHEMISTRY
Volume 6, Issue 4, Pages 309-314Publisher
AKADEMIAI KIADO RT
DOI: 10.1556/1846.2016.00011
Keywords
microreactor; nitration; kinetic; 5-nitroguaiacol
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Funding
- National Natural Science Foundation of China [91334201, U1463208, 21506110]
- China Postdoctoral Science Foundation [2015 M570111]
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Nitration of acetyl guaiacol, one typical aromatic nitration, is highly exothermic and extremely fast. Better control and high efficiency can be achieved in the microreactor due to its enhanced mixing and heat transfer rates. In this study, nitration of acetyl guaiacol was carried out in a microreactor using nitric acid-acetic acid as nitrating agent. The nitration kinetics was first investigated, and a kinetic model was established and revealed good prediction of experimental results at higher temperatures. Effects of molar ratio of nitric acid-acetyl guaiacol, residence time, temperature, and nitric acid concentration on the reaction were studied in detail. Under optimized condition, 90.7% yield of desired product, 5-nitroguaiacol, was achieved with 40% of nitric acid concentration, nitric acid-acetyl guaiacol molar ratio of 2.6, reaction temperature of 120 degrees C, and residence time of 2 min. Compared to traditional batch reactor, microreactor showed the advantages of higher yield and selectivity, much shorter reaction time, and less use of nitric acid.
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