Regenerative Approach to Scleroderma with Fat Grafting

Three surgical technique videos accompany this article showing the authors approach to the treatment of the face and of the hands in systemic sclerosis patients, and the inside of 2-mm, 14-gauge cannula harvesting and microfat injection with 0.8-mm, 21-gauge cannula endothelial progenitors, and immune cells. Fat grafting is being increasingly applied in autoimmune diseases, and this article focuses on systemic sclerosis, a rare autoimmune disease characterized by skin fibrosis and microvascular damage. The authors' approach of using fat graft in the face and adipose-tissue-derived stromal vascular fraction for hands is presented as innovative and promising therapy for patients with systemic sclerosis.