4.4 Article

Antibacterial activity of metal-phenanthroline complexes against multidrug-resistant Irish clinical isolates: a whole genome sequencing approach

Related references

Note: Only part of the references are listed.
Review Microbiology

Analysis of the Clinical Pipeline of Treatments for Drug-Resistant Bacterial Infections: Despite Progress, More Action Is Needed

Mark S. Butler et al.

Summary: There is an urgent global need for new strategies and drugs to control and treat multidrug-resistant bacterial infections. The World Health Organization has identified antibiotic-resistant priority pathogens and critically analyzed the antibacterial clinical pipeline. While new antibacterial drugs are being developed, there is still a lack of clinically differentiated agents.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2022)

Article Biochemistry & Molecular Biology

Copper(II) and silver(I)-1,10-phenanthroline-5,6-dione complexes interact with double-stranded DNA: further evidence of their apparent multi-modal activity towards Pseudomonas aeruginosa

Anna Clara Milesi Galdino et al.

Summary: The study found that Cu-phendione has a higher DNA binding affinity, can induce DNA damage, and cause DNA fragmentation. These results suggest that complexes containing phendione may elicit toxicity toward the multidrug-resistant pathogen P. aeruginosa through a novel DNA-targeted mechanism.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2022)

Article Medicine, General & Internal

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Christopher J. L. Murray et al.

Summary: Antimicrobial resistance (AMR) poses a significant threat to global human health, and this study provides the most comprehensive estimates of AMR burden to date. By estimating deaths and disability-adjusted life-years (DALYs) associated with bacterial AMR in 204 countries and territories in 2019, the study highlights the impact of resistance and the leading pathogen-drug combinations contributing to it.

LANCET (2022)

Article Biochemistry & Molecular Biology

In Vivo Activity of Metal Complexes Containing 1,10-Phenanthroline and 3,6,9-Trioxaundecanedioate Ligands against Pseudomonas aeruginosa Infection in Galleria mellonella Larvae

Megan O'Shaughnessy et al.

Summary: Novel metal complexes incorporating 1,10-phenanthroline ligands have shown antibacterial and anti-biofilm effects against drug-resistant Pseudomonas aeruginosa in vitro. This study demonstrates the in vivo efficacy of these metal complexes and their combination with gentamicin in treating P. aeruginosa infection in a model organism.

BIOMEDICINES (2022)

Article Biochemistry & Molecular Biology

The Genomic Basis of Rapid Adaptation to Antibiotic Combination Therapy in Pseudomonas aeruginosa

Camilo Barbosa et al.

Summary: Combination therapy is commonly used to reduce resistance evolution in infectious diseases, but its efficacy against Pseudomonas aeruginosa has been unclear. Whole-genome sequencing of evolved populations showed that changes in efflux pump regulation are a favored mechanism of resistance, with intergenic variants potentially playing a regulatory role in bacterial resistance evolution.

MOLECULAR BIOLOGY AND EVOLUTION (2021)

Article Multidisciplinary Sciences

Anomalous collapses of Nares Strait ice arches leads to enhanced export of Arctic sea ice

G. W. K. Moore et al.

Summary: Ice arches at the northern and southern ends of Nares Strait, a key passage in the Arctic, are forming for shorter durations, leading to increased ice transport and accelerating the export of multi-year ice.

NATURE COMMUNICATIONS (2021)

Editorial Material Public, Environmental & Occupational Health

Antimicrobial multidrug resistance in the era of COVID-19: a forgotten plight?

Eric Pelfrene et al.

Summary: The paper highlights the global issue of antimicrobial resistance and the potential exacerbation due to the ongoing COVID-19 pandemic. It stresses the need for collaboration to address the problem and emphasizes the importance of an integrated strategy to tackle this public health peril.

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL (2021)

Review Microbiology

Evaluation of metal-based antimicrobial compounds for the treatment of bacterial pathogens

Andris Evans et al.

Summary: Antimicrobial resistance (AMR) is a major global health challenge, with rising prevalence worldwide. The lack of antibiotics with novel modes of action hinders effective treatment of bacterial infections with resistance. Metal-based antibacterial compounds offer a promising solution for addressing this issue.

JOURNAL OF MEDICAL MICROBIOLOGY (2021)

Article Biotechnology & Applied Microbiology

Antibacterial activity and carbapenem re-sensitizing ability of 1,10-phenanthroline-5,6-dione and its metal complexes against KPC-producing Klebsiella pneumoniae clinical strains

I. Vianez Peregrino et al.

Summary: The study shows that phendione-based compounds, along with their metal-based complexes, can be used in combination with carbapenems to produce synergistic effects against multidrug-resistant KPC infections, re-sensitizing a large portion of non-susceptible strains.

LETTERS IN APPLIED MICROBIOLOGY (2021)

Article Microbiology

Silver(I) and Copper(II) Complexes of 1,10-Phenanthroline-5,6-Dione Against Phialophora verrucosa: A Focus on the Interaction With Human Macrophages and Galleria mellonella Larvae

Marcela Q. Granato et al.

Summary: The study indicates that 1,10-phenanthroline-5,6-dione and its metal-based complexes have promising therapeutic potential against fungal infections caused by Phialophora verrucosa, as they can inhibit growth, reduce biofilm formation and disarticulation, enhance killing of fungal cells by macrophages, and protect larvae from infection.

FRONTIERS IN MICROBIOLOGY (2021)

Review Biochemistry & Molecular Biology

The Role of ClpB in Bacterial Stress Responses and Virulence

Athar Alam et al.

Summary: Bacterial survival within a mammalian host relies on sensing environmental perturbations and initiating appropriate counter-responses, where bacterial chaperone systems, particularly ClpB, play indispensable roles. ClpB is crucial for bacterial survival under various stress conditions, especially heat shock, and also regulates secretion of bacterial effector molecules related to type VI secretion systems.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Article Parasitology

Anti-Leishmania braziliensis activity of 1,10-phenanthroline-5,6-dione and its Cu(II) and Ag(I) complexes

Ana Karina C. Lima et al.

Summary: Leishmaniasis, a neglected disease caused by parasite Leishmania, lacks an effective vaccine and relies on old drugs with side effects for treatment. A study on inhibitory effects of phendione and its metal complexes on parasite metallopeptidases and motility, as well as their impact on parasite-macrophage interaction, suggests their potential as new drugs against L. braziensis.

PARASITOLOGY RESEARCH (2021)

Article Multidisciplinary Sciences

Competing off-loading mechanisms of meropenem from an L,D-transpeptidase reduce antibiotic effectiveness

Trevor A. Zandi et al.

Summary: The carbapenem family of beta-lactam antibiotics has a broad spectrum of bactericidal activity, with promising results in treating tuberculosis. Research on the inhibition of mycobacterial Ldt sheds light on potential optimization strategies for next-generation carbapenems.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Infectious Diseases

Role of RND Efflux Pumps in Drug Resistance of Cystic Fibrosis Pathogens

Viola Camilla Scoffone et al.

Summary: This review summarizes the principal RND efflux pump families described in CF pathogens, with a focus on the main Gram-negative bacterial species, where RND pumps have been associated with MDR phenotypes.

ANTIBIOTICS-BASEL (2021)

Review Microbiology

Protein aggregation in bacteria

Frederic D. Schramm et al.

FEMS MICROBIOLOGY REVIEWS (2020)

Review Chemistry, Multidisciplinary

Classification of Metal-Based Drugs according to Their Mechanisms of Action

Eszter Boros et al.

Article Microbiology

NtrBC Regulates Invasiveness and Virulence of Pseudomonas aeruginosa During High-Density Infection

Morgan A. Alford et al.

FRONTIERS IN MICROBIOLOGY (2020)

Review Microbiology

Critical analysis of antibacterial agents in clinical development

Ursula Theuretzbacher et al.

NATURE REVIEWS MICROBIOLOGY (2020)

Editorial Material Microbiology

Tackling antimicrobial resistance by exploring new mechanisms of antibiotic action

Cruz L. Matos de Opitz et al.

FUTURE MICROBIOLOGY (2020)

Article Biotechnology & Applied Microbiology

Optimization of nitric oxide donors for investigating biofilm dispersal response inPseudomonas aeruginosaclinical isolates

Yu-ming Cai et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

Article Multidisciplinary Sciences

Characterization of different alginate lyases for dissolving Pseudomonas aeruginosa biofilms

Núria Blanco-Cabra et al.

Scientific Reports (2020)

Review Biochemistry & Molecular Biology

Pseudomonas aeruginosa Biofilms

Minh Tam Tran Thi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Chemistry, Multidisciplinary

New Antimicrobial Strategies Based on Metal Complexes

Mickael Claudel et al.

CHEMISTRY-SWITZERLAND (2020)

Article Toxicology

Antibiotics-induced oxidative stress

Andre Guillouzo et al.

CURRENT OPINION IN TOXICOLOGY (2020)

Review Infectious Diseases

Role of linezolid combination therapy for serious infections: review of the current evidence

Hao Chen et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2020)

Article Infectious Diseases

Metal Complexes, an Untapped Source of Antibiotic Potential?

Angelo Frei

ANTIBIOTICS-BASEL (2020)

Review Biochemistry & Molecular Biology

Two Component Regulatory Systems and Antibiotic Resistance in Gram-Negative Pathogens

Anjali Y. Bhagirath et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Microbiology

Relationship Between Quorum Sensing and Secretion Systems

Rocio Trastoy Pena et al.

FRONTIERS IN MICROBIOLOGY (2019)

Article Biotechnology & Applied Microbiology

Carbon Starvation Induces the Expression of PprB-Regulated Genes in Pseudomonas aeruginosa

Congcong Wang et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2019)

Review Infectious Diseases

Antimicrobial-resistant CC17 Enterococcus faecium: The past, the present and the future

Terence Lee et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2019)

Article Biotechnology & Applied Microbiology

Roles of D-Lactate Dehydrogenases in the Anaerobic Growth of Shewanella oneidensis MR-1 on Sugars

Takuya Kasai et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2019)

Review Biotechnology & Applied Microbiology

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

Zheng Pang et al.

BIOTECHNOLOGY ADVANCES (2019)

Review Infectious Diseases

Analysis of the clinical antibacterial and antituberculosis pipeline

Ursula Theuretzbacher et al.

LANCET INFECTIOUS DISEASES (2019)

Review Microbiology

Lifestyle transitions and adaptive pathogenesis of Pseudomonas aeruginosa

Martina Valentini et al.

CURRENT OPINION IN MICROBIOLOGY (2018)

Article Biochemistry & Molecular Biology

The cytotoxicity of some phenanthroline-based antimicrobial copper(II) and ruthenium(II) complexes

Neville S. Ng et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2018)

Review Chemistry, Medicinal

Recent advances in the medical use of silver complex

Xiaoxia Liang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Chemistry, Medicinal

Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity

Feng Chen et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

Pathogenic variants in glutamyl-tRNAGln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder

Marisa W. Friederich et al.

NATURE COMMUNICATIONS (2018)

Review Infectious Diseases

Silver and Antibiotic, New Facts to an Old Story

Frederic Barras et al.

ANTIBIOTICS-BASEL (2018)

Review Veterinary Sciences

The One Health Concept: 10 Years Old and a Long Road Ahead

Delphine Destoumieux-Garzon et al.

FRONTIERS IN VETERINARY SCIENCE (2018)

Review Microbiology

Mechanisms of quinolone action and resistance: where do we stand?

Susana Correia et al.

JOURNAL OF MEDICAL MICROBIOLOGY (2017)

Article Biochemistry & Molecular Biology

Silver potentiates aminoglycoside toxicity by enhancing their uptake

Marion Herisse et al.

MOLECULAR MICROBIOLOGY (2017)

Review Biochemistry & Molecular Biology

The Role of Reactive Oxygen Species in Antibiotic-Mediated Killing of Bacteria

Heleen Van Acker et al.

TRENDS IN MICROBIOLOGY (2017)

Review Immunology

Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence

M. Fata Moradali et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)

Article Multidisciplinary Sciences

Synergistic Antimicrobial Effects of Silver/Transition-metal Combinatorial Treatments

Javier A. Garza-Cervantes et al.

SCIENTIFIC REPORTS (2017)

Review Microbiology

Matrix exopolysaccharides; the sticky side of biofilm formation

Eve Maunders et al.

FEMS MICROBIOLOGY LETTERS (2017)

Article Infectious Diseases

Anti-Pseudomonas aeruginosa activity of 1,10-phenanthroline-based drugs against both planktonic- and biofilm-growing cells

Livia Viganor et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2016)

Review Biochemistry & Molecular Biology

Biofilms and Cyclic di-GMP (c-di-GMP) Signaling: Lessons from Pseudomonas aeruginosa and Other Bacteria

Martina Valentini et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Microbiology

Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model

Suguru Okuda et al.

NATURE REVIEWS MICROBIOLOGY (2016)

Article Microbiology

Mechanistic Basis of Antimicrobial Actions of Silver Nanoparticles

Tikam Chand Dakal et al.

Frontiers in Microbiology (2016)

Review Chemistry, Medicinal

Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It

Helen I. Zgurskaya et al.

ACS INFECTIOUS DISEASES (2015)

Review Microbiology

Wall Teichoic Acids of Gram-Positive Bacteria

Stephanie Brown et al.

ANNUAL REVIEW OF MICROBIOLOGY, VOL 67 (2013)

Article Chemistry, Inorganic & Nuclear

The antimicrobial properties of some copper(II) and platinum(II) 1,10-phenanthroline complexes

Neville S. Ng et al.

DALTON TRANSACTIONS (2013)

Review Microbiology

Antimicrobial activity of metals: mechanisms, molecular targets and applications

Joseph A. Lemire et al.

NATURE REVIEWS MICROBIOLOGY (2013)

Editorial Material Environmental Sciences

Understanding the Germicidal Effects of Silver Nanoparticles

Carol Potera

ENVIRONMENTAL HEALTH PERSPECTIVES (2012)

Article Nanoscience & Nanotechnology

Silver nanoparticle enhanced silver ion stress response in Escherichia coli K12

Jonathan S. McQuillan et al.

NANOTOXICOLOGY (2012)

Article Biochemistry & Molecular Biology

The SoxRS response of Escherichia coli is directly activated by redox-cycling drugs rather than by superoxide

Mianzhi Gu et al.

MOLECULAR MICROBIOLOGY (2011)

Article Cell Biology

The Bacterial Cell Envelope

Thomas J. Silhavy et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Review Chemistry, Medicinal

Cobalt Complexes as Antiviral and Antibacterial Agents

Eddie L. Chang et al.

PHARMACEUTICALS (2010)

Article Immunology

Pharmacokinetics and Pharmacodynamics of Antibacterial Agents

Matthew E. Levison et al.

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2009)

Article Microbiology

Comparison of the antimicrobial effects of chlorine, silver ion, and tobramycin on biofilm

Jaeeun Kim et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)

Article Biotechnology & Applied Microbiology

Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli

Woo Kyung Jung et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2008)

Article Microbiology

XphA/XqhA, a novel GspCD subunit for type II secretion in Pseudomonas aeruginosa

Gerard P. F. Michel et al.

JOURNAL OF BACTERIOLOGY (2007)