Cell cycle related long non-coding RNAs as the critical regulators of breast cancer progression and metastasis

Cell cycle is one of the main cellular mechanisms involved in tumor progression. Almost all of the active molecular pathways in tumor cells directly or indirectly target the cell cycle progression. Therefore, it is necessary to assess the molecular mechanisms involved in cell cycle regulation in tumor cells. Since, early diagnosis has pivotal role in better cancer management and treatment, it is required to introduce the non-invasive diagnostic markers. Long non-coding RNAs (LncRNAs) have higher stability in body fluids in comparison with mRNAs. Therefore, they can be used as efficient non-invasive markers for the early detection of breast cancer (BCa). In the present review we have summarized all of the reported lncRNAs involved in cell cycle regulation in BCa. It has been reported that lncRNAs mainly affect the cell cycle in G1/S transition through the CCND1/CDK4-6 complex. Present review paves the way of introducing the cell cycle related lncRNAs as efficient markers for the early detection of BCa.

Automated summary

Cell cycle plays a crucial role in tumor progression, and molecular pathways targeting cell cycle progression are of great interest in cancer research. Long non-coding RNAs (LncRNAs) have been identified as potential non-invasive markers for the early detection of breast cancer due to their stability in body fluids. In this review, we summarize the reported LncRNAs involved in cell cycle regulation in breast cancer, with a focus on their impact on the G1/S transition through the CCND1/CDK4-6 complex. This review provides insights into the potential of cell cycle-related LncRNAs as efficient markers for early breast cancer detection.