Journal
CLINICAL ORAL INVESTIGATIONS
Volume 27, Issue 1, Pages 421-430Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00784-022-04844-9
Keywords
Bioavailability; Periodontitis; Vitamin D; Vitamin D-binding protein
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This study investigates the relationship between total, free, and bioavailable 25-hydroxyvitamin D levels and periodontitis. Serum samples from 39 patients with periodontitis and 44 healthy participants were analyzed for various biomarkers. The results show that total, free, and bioavailable 25-hydroxyvitamin D levels are significantly lower in the periodontitis group, and there is a significant correlation between total 25-hydroxyvitamin D and periodontitis. Additionally, measuring free and bioavailable 25-hydroxyvitamin D levels does not provide additional advantages in understanding the relationship between periodontitis and vitamin D.
Objective The aim of this study was to investigate the relationship between total, free and bioavailable 25-hydroxyvitamin D levels, and periodontitis.Materials and methods Thirty-nine patients with periodontitis diagnosis and 44 healthy participants were included in this study. 25-Hydroxyvitamin D, vitamin D-binding protein, procalcitonin, and albumin levels were measured from the serum samples obtained. Free and bioavailable 25-hydroxyvitamin D levels were calculated. Total, free, and bioavailable 25-hydroxyvitamin D levels were compared between the healthy control and periodontitis groups. The association of total 25 (OH)D levels with periodontitis was tested through univariate analysis and multivariate logistic regression.Results Total 25-hydroxyvitamin D, bioavailable 25-hydroxyvitamin D, and free 25-hydroxyvitamin D levels were significantly lower in the periodontitis group than in the healthy control group (p < 0.001). In the logistic regression analysis, a significant correlation was observed between total 25-hydroxyvitamin D and periodontitis (p < 0.001).Conclusion Our study shows that there is a relationship between total, free and bioavailable 25-hydroxyvitamin D levels and periodontitis. In addition, it has been shown that the determination of free and bioavailable 25-hydroxyvitamin D levels does not provide additional advantages in terms of the relationship between periodontitis and vitamin D.
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