Total, free, and bioavailable 25-hydroxyvitamin D levels in patients with periodontitis (stage III): a case-control study

Objective The aim of this study was to investigate the relationship between total, free and bioavailable 25-hydroxyvitamin D levels, and periodontitis.Materials and methods Thirty-nine patients with periodontitis diagnosis and 44 healthy participants were included in this study. 25-Hydroxyvitamin D, vitamin D-binding protein, procalcitonin, and albumin levels were measured from the serum samples obtained. Free and bioavailable 25-hydroxyvitamin D levels were calculated. Total, free, and bioavailable 25-hydroxyvitamin D levels were compared between the healthy control and periodontitis groups. The association of total 25 (OH)D levels with periodontitis was tested through univariate analysis and multivariate logistic regression.Results Total 25-hydroxyvitamin D, bioavailable 25-hydroxyvitamin D, and free 25-hydroxyvitamin D levels were significantly lower in the periodontitis group than in the healthy control group (p < 0.001). In the logistic regression analysis, a significant correlation was observed between total 25-hydroxyvitamin D and periodontitis (p < 0.001).Conclusion Our study shows that there is a relationship between total, free and bioavailable 25-hydroxyvitamin D levels and periodontitis. In addition, it has been shown that the determination of free and bioavailable 25-hydroxyvitamin D levels does not provide additional advantages in terms of the relationship between periodontitis and vitamin D.

Automated summary

This study investigates the relationship between total, free, and bioavailable 25-hydroxyvitamin D levels and periodontitis. Serum samples from 39 patients with periodontitis and 44 healthy participants were analyzed for various biomarkers. The results show that total, free, and bioavailable 25-hydroxyvitamin D levels are significantly lower in the periodontitis group, and there is a significant correlation between total 25-hydroxyvitamin D and periodontitis. Additionally, measuring free and bioavailable 25-hydroxyvitamin D levels does not provide additional advantages in understanding the relationship between periodontitis and vitamin D.