Sub Chronic Toxic Effects of Ethanolic Pongamia pinnata and Eucalyptus camaldulensis Leaf Extracts on Hematological and Biochemical Parameters of Blood in the Male Albino Mice

This study involves effects of ethanolic extracts of leaves of Pongamia pinnata (L.) Pierre and Eucalyptus camaldulensis Dehnh on hematological parameters and biochemical components of blood serum of male albino mice. The extracts were administrated orally (100 mg/ ml solvent/ Kg body weight) for 15 days and it was observed that the complete blood count (CBC) remained unaffected while cholesterol (P = 0.03) and triglyceride (P = 0.008) levels in serum were significantly elevated in P. pinnata leaf extract treated mice. Mice treated with E. camaldulensis leaf extract had significantly reduced white blood cells (P = 0.05), platelets (P = 0.05), alanine aminotransferase (P = 0.04) and significantly increased mean corpuscular hemoglobin levels (P = 0.04) as compared to control group. Our results indicated that both leaf extracts had tendency to disturb the blood biochemistry of healthy male albino mice. The effects were more pronounced in mice orally treated with E. camaldulensis leaf extract for 15 days.

Automated summary

This study investigated the effects of ethanolic extracts of Pongamia pinnata (L.) Pierre leaves and Eucalyptus camaldulensis Dehnh leaves on hematological parameters and biochemical components of blood serum in male albino mice. The results showed that the P. pinnata leaf extract significantly increased cholesterol and triglyceride levels, while the E. camaldulensis leaf extract significantly reduced white blood cells, platelets, and alanine aminotransferase, and increased mean corpuscular hemoglobin levels. Both extracts showed a potential to disturb the blood biochemistry of healthy male albino mice, with more pronounced effects observed with the E. camaldulensis leaf extract.