Journal
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
Volume 61, Issue 3, Pages 3090-3094Publisher
SOC CHILENA QUIMICA
DOI: 10.4067/S0717-97072016000300017
Keywords
Homogeneous liquid-liquid extraction; salt and air-assisted; saccharine; caffeine; salicylic acid; benzoic acid; high-performance liquid chromatography
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Funding
- Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences
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Saccharine, caffeine, salicylic acid and benzoic acid were extracted and quantified simultaneously by coupling the salt and air-assisted homogeneous liquid-liquid extraction (SAAHLLE) technique with high-performance liquid chromatography (HPLC). Various parameters such as extraction solvent and its volume, salt and its concentration, volume of injected air, vortex time and sample pH were evaluated and optimized. Analytical parameters of the proposed method were determined under the optimized conditions. The calibration curves showed good linearity in the range of 5-100 mu g/mL for saccharine, caffeine, salicylic acid and benzoic acid. The limit of detection (LOD) values for saccharine, caffeine, salicylic acid and benzoic acid were 0.024, 0.013, 0.0048 and 0.0052 ng/mL, respectively. The recoveries were in the range of 88.0-94.0% with RSD values ranging from 3.8 to 6.8%.
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