COVID-19 Symptoms by Variant Period in the North Carolina COVID-19 Community Research Partnership, North Carolina, USA

Article Immunology

Symptoms and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Positivity in the General Population in the United Kingdom

Karina-Doris Vihta et al.

Summary: This study compared the ability of different symptoms to identify SARS-CoV-2 infection at specific time points and by vaccination status. The findings suggest that expanding symptom combinations can improve the sensitivity of PCR testing, but it also increases the number of tests per case. Therefore, when implementing large-scale testing strategies, various factors need to be taken into consideration.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Multidisciplinary Sciences

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

Bo Meng et al.

Summary: The Omicron variant of SARS-CoV-2 has a higher affinity for ACE2 and can evade neutralizing antibodies more effectively compared to the Delta variant. A third dose of mRNA vaccine can provide enhanced protection. Omicron has lower replication in lung and gut cells and less efficiently cleaves its spike protein compared to Delta.

NATURE (2022)

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Article Infectious Diseases

Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study

Katherine A. Twohig et al.

Summary: A study in England found that patients with COVID-19 infected with the delta variant were more likely to be admitted to hospital or attend emergency care compared to those infected with the alpha variant. This suggests that outbreaks of the delta variant in unvaccinated populations may pose a greater burden on healthcare services.

LANCET INFECTIOUS DISEASES (2022)

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Article Medicine, General & Internal

Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study

Cristina Menni et al.

Summary: This study investigated the differences in symptom prevalence, risk of hospital admission, and symptom duration between omicron and delta variants of the SARS-CoV-2 virus. The study found that loss of smell was less common in omicron infections, sore throat was more common, and the rate of hospital admission was lower.

LANCET (2022)

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Letter Infectious Diseases

A SARS-CoV-2 omicron (B.1.1.529) variant outbreak in a primary school in Geneva, Switzerland

Elsa Lorthe et al.

LANCET INFECTIOUS DISEASES (2022)

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Letter Medicine, General & Internal

Effectiveness of Ad26.COV2.S and BNT162b2 Vaccines against Omicron Variant in South Africa

Glenda Gray et al.

Summary: The effectiveness of two doses of the BNT162b2 mRNA vaccine and the Ad26.COV2.S vaccine in South Africa against the omicron variant was assessed. Both vaccines provided a high level of protection against severe Covid-19.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Clinical outcomes associated with SARS-CoV-2 Omicron (B.1.1.529) variant and BA.1/BA.1.1 or BA.2 subvariant infection in Southern California

Joseph A. Lewnard et al.

Summary: Comparison of outcomes of SARS-CoV-2 Delta and Omicron infections reveals reduced severity of Omicron infections, especially in unvaccinated individuals. There is no differential risk of severe outcomes between subvariants BA.1 and BA.2. Continual assessment of clinical outcomes associated with SARS-CoV-2 variants is crucial for medical interventions and healthcare resource management.

NATURE MEDICINE (2022)

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Article Infectious Diseases

Outbreak caused by the SARS-CoV-2 Omicron variant in Norway, November to December 2021

Lin T. Brandal et al.

Summary: In the Omicron SARS-CoV-2 outbreak in Oslo, Norway, most infected individuals were aged 30-50, 96% were vaccinated, with an attack rate of 74%, but none required hospitalization.

EUROSURVEILLANCE (2021)

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Article Infectious Diseases

Epidemiological characterisation of the first 785 SARS-CoV-2 Omicron variant cases in Denmark, December 2021

Laura Espenhain et al.

Eurosurveillance (2021)

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Article Medicine, General & Internal

Effectiveness of mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: a retrospective cohort study

Sara Y. Tartof et al.

Summary: This study aimed to assess the overall and variant-specific effectiveness of the BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19-related hospital admissions among members of a healthcare system in California. The effectiveness of the vaccine remained high against hospital admissions even up to 6 months after full vaccination, despite a decline in effectiveness against SARS-CoV-2 infections over time, which was likely due to waning immunity rather than the delta variant escaping vaccine protection.

LANCET (2021)

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Article Public, Environmental & Occupational Health

SARS-CoV-2 B.1.1.529 (Omicron) Variant — United States, December 1–8, 2021

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Article Medicine, General & Internal

Clustering and longitudinal change in SARS-CoV-2 seroprevalence in school children in the canton of Zurich, Switzerland: prospective cohort study of 55 schools

Agne Ulyte et al.

Summary: This study examined longitudinal changes in SARS-CoV-2 seroprevalence and clustering of seropositive children in schools in Zurich, Switzerland from June to November 2020. The overall seroprevalence increased during this period, with varying rates across districts. The clustering of seropositive children was observed in only a few classes, indicating that with schools open and preventive measures in place, transmission of SARS-CoV-2 among children was limited despite community transmission.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

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Review Psychiatry

Accuracy and bias in retrospective symptom reporting

Omer Van den Bergh et al.

CURRENT OPINION IN PSYCHIATRY (2016)

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COVID-19 Symptoms by Variant Period in the North Carolina COVID-19 Community Research Partnership, North Carolina, USA

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