Efficient Inactivation of Monkeypox Virus by World Health Organization-Recommended Hand Rub Formulations and Alcohols

Increasing nonzoonotic human monkeypox virus (MPXV) infections urge reevaluation of inactivation strategies. We demonstrate efficient inactivation of MPXV by 2 World Health Organization-recommended alcohol-based hand rub solutions. When compared with other (re)emerging enveloped viruses, MPXV displayed the greatest sta-bility. Our results support rigorous adherence to use of alcohol-based disinfectants.

Automated summary

Given the increasing cases of nonzoonotic human monkeypox virus (MPXV) infections, it is necessary to reevaluate inactivation strategies. This study demonstrates the effectiveness of 2 alcohol-based hand rub solutions recommended by the World Health Organization in inactivating MPXV. Compared to other (re)emerging enveloped viruses, MPXV shows the highest stability. These findings emphasize the importance of using alcohol-based disinfectants.