4.7 Review

The Role of SOX Transcription Factors in Ageing and Age-Related Diseases

Related references

Note: Only part of the references are listed.
Article Neurosciences

Sox-positive cell population in the adult cerebellum increases upon tissue degeneration

Shelanah Salih et al.

Summary: Recent observations suggest that Bergmann glia in the cerebellum may play a role in tissue repair due to their expression of neural stem cell markers, although the physiological relevance of this overlap remains unclear in the absence of established in vivo evidence of tissue regeneration in the adult cerebellum.

EXPERIMENTAL NEUROLOGY (2022)

Article Cell Biology

SoxD genes are required for adult neural stem cell activation

Lingling Li et al.

Summary: Research shows that SoxD transcription factors Sox5 and Sox6 are enriched in activated radial glia-like neural stem cells, and deletion of these genes in adult mouse brains affects RGL activation and generation of new neurons. Loss of Sox5 also hinders activation of RGLs driven by neurogenic stimuli.

CELL REPORTS (2022)

Article Biology

Characterization of the neurogenic niche in the aging dentate gyrus using iterative immunofluorescence imaging

John Darby Cole et al.

Summary: Advancing age leads to decreased hippocampal neurogenesis, which is associated with age-related cognitive decline. The reorganization of the dentate gyrus (DG) niche and changes in the cell-type contributions to the blood-brain barrier and microenvironments surrounding neural stem cells (NSCs) play a pivotal role in maintaining neurogenic permissiveness.

ELIFE (2022)

Review Biochemistry & Molecular Biology

Integrated Multi-Omics for Novel Aging Biomarkers and Antiaging Targets

Lei Wu et al.

Summary: Aging is closely related to human diseases, but its biological mechanism remains unclear. This review summarizes multi-omics methods and highlights the importance of integrating different omics technologies to reveal the interactions among aging molecules from a multidimensional perspective. The findings provide new insights into the discovery of aging biomarkers, understanding the mechanism of aging, and identifying novel targets for antiaging interventions.

BIOMOLECULES (2022)

Review Biochemistry & Molecular Biology

Reactive and Senescent Astroglial Phenotypes as Hallmarks of Brain Pathologies

Andrijana Lazic et al.

Summary: This review summarizes the latest research on astrocyte reactivation and senescence, and compares their similarities and differences in terms of morphology, function, and molecular aspects. The article specifically focuses on the role of these cellular changes in neurodegenerative diseases, and discusses the potential of astrocytes as therapeutic targets.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Cell Biology

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice

Kristen C. Browder et al.

Summary: Partial reprogramming can restore a youthful epigenetic signature to aging cells and extend the lifespan of a premature aging mouse model. Long-term partial reprogramming has rejuvenating effects on different tissues and at the organismal level. The extent of the beneficial effects depends on the duration of the treatment. The rejuvenating effects are associated with a reversion of the epigenetic clock and changes in metabolism and gene expression.

NATURE AGING (2022)

Review Cell Biology

Interplay of SOX transcription factors and microRNAs in the brain under physiological and pathological conditions

Milena Stevanovic et al.

Summary: Precise tuning of gene expression, accomplished by regulatory networks of transcription factors, epigenetic modifiers, and microRNAs, is crucial for proper neural development and brain function. The complex regulatory network between SOX transcription factors and microRNAs plays important roles in neurogenesis. Deregulated SOX/microRNA interplay has been associated with various brain pathologies. Therapeutic strategies targeting the interplay have emerged as a promising tool for neural tissue regeneration and neurorestoration.

NEURAL REGENERATION RESEARCH (2022)

Review Geriatrics & Gerontology

Clinical Trials Targeting Aging

Johannes Leth Nielsen et al.

Summary: The risk of morbidity and mortality increases exponentially with age due to factors such as chronic inflammation, DNA damage accumulation, dysfunctional mitochondria, and increased senescent cell load. Mechanistic investigations have identified specific pathways and processes that contribute to age-related phenotypes, such as frailty and multi-morbidity. Promising treatments for mitigating aging consequences include caloric restriction and pharmacological targeting of longevity pathways. However, it remains uncertain if these results can be translated to humans.

FRONTIERS IN AGING (2022)

Article Cell Biology

A Single-Cell Transcriptomic Atlas of Human Skin Aging

Zhiran Zou et al.

Summary: Single-cell RNA sequencing of human eyelid skin revealed progressive accumulation of photoaging-related changes and increased chronic inflammation with age. Transcriptional factors involved in the developmental process showed early-onset decline during aging. Inhibition of key transcription factors HES1 and KLF6 compromised cell proliferation, increased inflammation, and accelerated cellular senescence during aging.

DEVELOPMENTAL CELL (2021)

Article Cell Biology

Genes and pathways involved in senescence bypass identified by functional genetic screens

Eugenia Roupakia et al.

Summary: Cellular senescence is a stable and irreversible cell cycle arrest triggered by various stimuli, including telomere shortening and oxidative, genotoxic, or oncogenic stresses. Effector mechanisms such as DNA damage responses, senescence-associated secretory phenotype, and epigenetic changes play important roles in senescence programmes. Despite its role as a cancer barrier, bypassing senescence may lead to the development of malignancies. Functional genetic screens have identified genes, pathways, and mechanisms involved in senescence evasion, including cell cycle regulators, DNA damage response pathways, and noncoding RNAs.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

Article Multidisciplinary Sciences

SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation

Abdul Haseeb et al.

Summary: SOX9 is essential for embryonic chondrogenesis, and its deficiency in postnatal stages leads to growth-plate closure and deterioration of articular cartilage. The absence of SOX9 prompts growth-plate chondrocytes to rapidly reach a terminal/dedifferentiated stage and undergo overt osteoblastogenesis. Further research reveals the role of SOX9 in controlling TGF beta and BMP signaling activities during chondrocyte lineage transition.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Geriatrics & Gerontology

Identification of Sox2 and NeuN Double-Positive Cells in the Mouse Hypothalamic Arcuate Nucleus and Their Reduction in Number With Aging

Ayumu Sugiura et al.

Summary: Aging induces loss of neural stem cells and inflammation in the hypothalamus, with high-fat diet fed mice showing similar alterations in the hypothalamus to aged mice. This study provides new insights into aging-induced changes in the hypothalamus.

FRONTIERS IN AGING NEUROSCIENCE (2021)

Review Medicine, Research & Experimental

Evidence and perspectives of cell senescence in neurodegenerative diseases

Zizhen Si et al.

Summary: With increasing life expectancies, there has been a significant rise in the number of individuals suffering from geriatric neurodegenerative diseases such as AD and PD, leading to overwhelming financial and societal costs. Recent high-profile clinical trials for these diseases have largely failed, emphasizing the urgent need for novel treatment approaches.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Cell & Tissue Engineering

Early stem cell aging in the mature brain

Albina Ibrayeva et al.

Summary: The research highlights the vulnerability and adaptability of hippocampal neural stem cells to cellular aging, as multiple factors disrupt these cells' behavior in the adult brain, including rapid-dividing short-term NSCs and multipotent long-term NSCs maintained for months but pushed out of homeostasis by extended quiescence.

CELL STEM CELL (2021)

Review Cell & Tissue Engineering

SOX transcription factors and glioma stem cells: Choosing between stemness and differentiation

Milena Stevanovic et al.

Summary: GBM, the most common, aggressive, and deadly brain tumor, is linked to glioma stem cells and SOX transcription factors which play a vital role in stem cell maintenance and differentiation. Overcoming GBM has been a challenging goal, with current therapies showing only slight improvement in patient survival, requiring fine-tuning of multimodal therapeutic strategies to target different cancer cell hallmarks.

WORLD JOURNAL OF STEM CELLS (2021)

Review Cell Biology

Retinal Stem/Progenitor Cells Derived From Adult Muller Glia for the Treatment of Retinal Degeneration

Lay Khoon Too et al.

Summary: Over the past two decades, significant progress has been made in understanding the functions of glial cells, particularly Muller glia (MG), in retinal homeostasis and regeneration. While MG show regenerative capacity varying across species, their in vivo regenerative potential in mammals, including humans, is limited. Advances in stem cell therapy have shed light on critical mechanisms underlying MG reprogramming in fish, showing promising results when applied to rodents.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Conservation of Aging and Cancer Epic enetic Signatures across Human and Mouse

Raul F. Perez et al.

Summary: The study found parallel epigenetic alterations in aging and cancer, with potential differences in DNA hypomethylation. While most observations came from mouse models, systematic comparisons of human and mouse epigenetic patterns in disease context are lacking. The research suggests the conservation of specific cancer and aging epigenomic signatures in human and mouse, indicating the functional consequences of these alterations at multiple levels of genomic regulation.

MOLECULAR BIOLOGY AND EVOLUTION (2021)

Article Orthopedics

The effect of SOX4 gene 3′UTR polymorphisms on osteoporosis

Guo Li et al.

Summary: The SOX4 gene SNPs rs79958549, rs139085828, and rs201335371 loci were found to be significantly associated with osteoporosis susceptibility. Carriers of specific alleles at these loci had either increased or decreased risk of developing osteoporosis. The interaction between genetic factors and clinical characteristics also played a role in predicting osteoporosis risk.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2021)

Review Neurosciences

SOX Transcription Factors as Important Regulators of Neuronal and Glial Differentiation During Nervous System Development and Adult Neurogenesis

Milena Stevanovic et al.

Summary: SOX proteins are a superfamily of transcription factors that play crucial roles in regulating multiple developmental and physiological processes, governing diverse cellular processes and influencing survival and homeostasis in adult tissues. Their roles are not limited to development, as they also impact cell survival, regeneration, and control of homeostasis in adult tissues.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

Review Oncology

Cancer and Aging: Two Tightly Interconnected Biological Processes

Lieze Berben et al.

Summary: Aging is a major risk factor for cancer, leading to challenges in treatment for older patients. The balance between treatment benefits and toxicity risk must be carefully considered. Robust biomarkers reflecting biological age can aid in personalized treatment for elderly cancer patients.

CANCERS (2021)

Article Health Care Sciences & Services

Viability of Quercetin-Induced Dental Pulp Stem Cells in Forming Living Cellular Constructs for Soft Tissue Augmentation

Hytham N. Fageeh et al.

Summary: The study assessed the potential of quercetin-induced living cell constructs derived from dental pulp stem cells for soft tissue augmentation. The induced constructs showed good handling properties and exhibited characteristics of cells embedded in tissue matrix, along with increased expression of stemness-related genes.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Review Oncology

Lung Cancer Stem Cells-Origin, Diagnostic Techniques and Perspective for Therapies

Agata Raniszewska et al.

Summary: Lung cancer poses a serious oncological issue worldwide, with cancer stem cells (CSCs) playing a crucial role in tumor initiation and metastasis. Age remains a significant risk factor for lung cancer development. The biology of this cancer continues to be an intriguing area of research, especially in terms of understanding the role of CSCs and age-related changes in carcinogenesis.

CANCERS (2021)

Review Oncology

The role of SOX family members in solid tumours and metastasis

Daniela Grimm et al.

SEMINARS IN CANCER BIOLOGY (2020)

Review Genetics & Heredity

The genetics of human ageing

David Melzer et al.

NATURE REVIEWS GENETICS (2020)

Editorial Material Pharmacology & Pharmacy

Is anti-ageing drug discovery becoming a reality?

Alexey Moskalev

EXPERT OPINION ON DRUG DISCOVERY (2020)

Article Cell & Tissue Engineering

Restoring aged stem cell functionality: Current progress and future directions

Kevin Spehar et al.

STEM CELLS (2020)

Article Multidisciplinary Sciences

SOX3 promotes generation of committed spermatogonia in postnatal mouse testes

Dale McAninch et al.

SCIENTIFIC REPORTS (2020)

Article Endocrinology & Metabolism

Long-term trends in the prescription of antidiabetic drugs: real-world evidence from the Diabetes Registry Tyrol 2012-2018

Clemens Engler et al.

BMJ OPEN DIABETES RESEARCH & CARE (2020)

Article Cell Biology

SOX2 expression diminishes with ageing in several tissues in mice and humans

Estefania Carrasco-Garcia et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2019)

Article Integrative & Complementary Medicine

Metformin Promotes Neuronal Differentiation via Crosstalk between Cdk5 and Sox6 in Neuroblastoma Cells

Thunwa Binlateh et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

Review Biochemistry & Molecular Biology

More than just Stem Cells: Functional Roles of the Transcription Factor Sox2 in Differentiated Glia and Neurons

Sara Mercurio et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity

Jorge Ivan Castillo-Quan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Geriatrics & Gerontology

Gene expression hallmarks of cellular ageing

Stephen Frenk et al.

BIOGERONTOLOGY (2018)

Review Biochemistry & Molecular Biology

Regulation of Age-related Decline by Transcription Factors and Their Crosstalk with the Epigenome

Xin Zhou et al.

CURRENT GENOMICS (2018)

Article Multidisciplinary Sciences

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

Tyler J. Bussian et al.

NATURE (2018)

Review Cell & Tissue Engineering

Osteogenesis and aging: lessons from mesenchymal stem cells

Arantza Infante et al.

STEM CELL RESEARCH & THERAPY (2018)

Editorial Material Geriatrics & Gerontology

How healthy is the healthspan concept?

Matt Kaeberlein

GEROSCIENCE (2018)

Article Multidisciplinary Sciences

Sox2 is associated with cancer stem-like properties in colorectal cancer

Koki Takeda et al.

SCIENTIFIC REPORTS (2018)

Review Respiratory System

Chronic obstructive pulmonary disease and the hallmarks of aging

Shweta P. Kukrety et al.

LUNG INDIA (2018)

Review Geriatrics & Gerontology

Regeneration of the Aging Lung: A Mini-Review

Sonia Navarro et al.

GERONTOLOGY (2017)

Article Multidisciplinary Sciences

Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics

James E. Dahlman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Cell & Tissue Engineering

Evidence for a retinal progenitor cell in the postnatal and adult mouse

Xi Chen et al.

STEM CELL RESEARCH (2017)

Article Cell Biology

Pathology of Neurodegenerative Diseases

Brittany N. Dugger et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)

Article Multidisciplinary Sciences

SOX14 activates the p53 signaling pathway and induces apoptosis in a cervical carcinoma cell line

Danijela Stanisavljevic et al.

PLOS ONE (2017)

Review Orthopedics

An overview of osteoporosis and frailty in the elderly

Guowei Li et al.

BMC MUSCULOSKELETAL DISORDERS (2017)

Review Transplantation

The application of multi-omics and systems biology to identify therapeutic targets in chronic kidney disease

Katryna Cisek et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2016)

Article Biochemistry & Molecular Biology

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

Alejandro Ocampo et al.

Article Hematology

Dasatinib promotes the activation of quiescent hematopoietic stem cells in mice

Johanna M. Duyvestyn et al.

EXPERIMENTAL HEMATOLOGY (2016)

Article Biochemistry & Molecular Biology

Dynamic epigenetic mechanisms regulate age-dependent SOX9 expression in mouse articular cartilage

Mingcai Zhang et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)

Review Biochemistry & Molecular Biology

The Aging Epigenome

Lauren N. Booth et al.

MOLECULAR CELL (2016)

Article Multidisciplinary Sciences

SOX9-regulated cell plasticity in colorectal metastasis is attenuated by rapamycin

Estefania Carrasco-Garcia et al.

SCIENTIFIC REPORTS (2016)

Article Multidisciplinary Sciences

Preserved neurogenesis in non-demented individuals with AD neuropathology

David Briley et al.

SCIENTIFIC REPORTS (2016)

Article Multidisciplinary Sciences

The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1

Danijela Drakulic et al.

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS (2015)

Review Oncology

The crossroads between cancer stem cells and aging

Sara Santos Franco et al.

BMC CANCER (2015)

Article Gastroenterology & Hepatology

SOX9 Maintains Reserve Stem Cells and Preserves Radioresistance in Mouse Small Intestine

Kyle C. Roche et al.

GASTROENTEROLOGY (2015)

Article Geriatrics & Gerontology

Changes in hippocampal neurogenesis throughout early development

Sjoukje D. Kuipers et al.

NEUROBIOLOGY OF AGING (2015)

Article Cell Biology

Adult Neurogenesis in Neurodegenerative Diseases

Beate Winner et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Review Chemistry, Medicinal

The role of dasatinib in the management of chronic myeloid leukemia

Runzhe Chen et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2015)

Review Cell Biology

From CNS stem cells to neurons and glia: Sox for everyone

Simone Reiprich et al.

CELL AND TISSUE RESEARCH (2015)

Article Multidisciplinary Sciences

SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines

Isidora Petrovic et al.

PLOS ONE (2015)

Article Medical Laboratory Technology

Low SOX17 expression: prognostic significance in de novo acute myeloid leukemia with normal cytogenetics

Chun-yan Tang et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2014)

Review Cell Biology

Cellular senescence and its effector programs

Rafik Salama et al.

GENES & DEVELOPMENT (2014)

Article Orthopedics

Characterization of age-related changes of tendon stem cells from adult human tendons

Laura Ruzzini et al.

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY (2014)

Review Cell Biology

Cellular senescence: from physiology to pathology

Daniel Munoz-Espin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Multidisciplinary Sciences

Sox10 Expressing Cells in the Lateral Wall of the Aged Mouse and Human Cochlea

Xinping Hao et al.

PLOS ONE (2014)

Article Gastroenterology & Hepatology

Simultaneous laparoscopic resection of primary colorectal cancer and associated liver metastases: a systematic review

R. M. Lupinacci et al.

TECHNIQUES IN COLOPROCTOLOGY (2014)

Review Medical Laboratory Technology

Drugs that modulate aging: the promising yet difficult path ahead

Brian K. Kennedy et al.

TRANSLATIONAL RESEARCH (2014)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Article Developmental Biology

Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis

Nicholas Rogers et al.

GENE EXPRESSION PATTERNS (2013)

Article Geriatrics & Gerontology

Patterns and Predictors of Generic Narrow Therapeutic Index Drug Use Among Older Adults

Joshua J. Gagne et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2013)

Article Multidisciplinary Sciences

Reprogramming in vivo produces teratomas and iPS cells with totipotency features

Maria Abad et al.

NATURE (2013)

Review Genetics & Heredity

Mechanisms and models of somatic cell reprogramming

Yosef Buganim et al.

NATURE REVIEWS GENETICS (2013)

Article Biochemistry & Molecular Biology

Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing

Robi Tacutu et al.

NUCLEIC ACIDS RESEARCH (2013)

Article Multidisciplinary Sciences

Autophagy and Cellular Senescence Mediated by Sox2 Suppress Malignancy of Cancer Cells

Yong-Yeon Cho et al.

PLOS ONE (2013)

Article Ophthalmology

Anatomic Alterations in Aging and Age-Related Diseases of the Eye

Hans E. Grossniklaus et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2013)

Article Cell Biology

Age-related cognitive decline: Can neural stem cells help us?

Benedetta Artegiani et al.

AGING-US (2012)

Article Oncology

Oncogenicity of the Developmental Transcription Factor Sox9

Ander Matheu et al.

CANCER RESEARCH (2012)

Article Biochemistry & Molecular Biology

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

Wenjun Guo et al.

Editorial Material Cell Biology

Rejuvenating regeneration Metformin activates endogenous adult stem cells

Javier A. Menendez et al.

CELL CYCLE (2012)

Article Developmental Biology

Sox1 marks an activated neural stem/progenitor cell in the hippocampus

Monica Venere et al.

DEVELOPMENT (2012)

Article Biochemistry & Molecular Biology

Global heterochromatin loss A unifying theory of aging?

Amy Tsurumi et al.

EPIGENETICS (2012)

Review Pharmacology & Pharmacy

Genome-Environment Interactions That Modulate Aging: Powerful Targets for Drug Discovery

Joao Pedro de Magalhaes et al.

PHARMACOLOGICAL REVIEWS (2012)

Article Critical Care Medicine

SOX5 Is a Candidate Gene for Chronic Obstructive Pulmonary Disease Susceptibility and Is Necessary for Lung Development

Craig P. Hersh et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

Article Cell & Tissue Engineering

Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice

Katrin Arnold et al.

CELL STEM CELL (2011)

Review Neurosciences

Neurodegenerative disease and adult neurogenesis

Beate Winner et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2011)

Article Endocrinology & Metabolism

Molecular Disease Map of Bone Characterizing the Postmenopausal Osteoporosis Phenotype

Rune Jemtland et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2011)

Review Cell Biology

Manifestations and mechanisms of stem cell aging

Ling Liu et al.

JOURNAL OF CELL BIOLOGY (2011)

Article Neurosciences

Age-Related Alterations in Neurons of the Mouse Retina

Melanie A. Samuel et al.

JOURNAL OF NEUROSCIENCE (2011)

Review Cell Biology

Emerging models and paradigms for stem cell ageing

D. Leanne Jones et al.

NATURE CELL BIOLOGY (2011)

Article Geriatrics & Gerontology

Primate-specific alterations in neural stem/progenitor cells in the aged hippocampus

Ken Aizawa et al.

NEUROBIOLOGY OF AGING (2011)

Review Biochemistry & Molecular Biology

Epigenetic regulation of aging stem cells

E. A. Pollina et al.

ONCOGENE (2011)

Review Cell & Tissue Engineering

Stem Cells and the Niche: A Dynamic Duo

Justin Voog et al.

CELL STEM CELL (2010)

Article Oncology

Targeting Notch to Target Cancer Stem Cells

Antonio Pannuti et al.

CLINICAL CANCER RESEARCH (2010)

Review Immunology

Aging of the innate immune system

Albert C. Shaw et al.

CURRENT OPINION IN IMMUNOLOGY (2010)

Article Neurosciences

Expression of Pax6 and Sox2 in Adult Olfactory Epithelium

Zhen Guo et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2010)

Article Neurosciences

Age-Related Deterioration of Rod Vision in Mice

Alexander V. Kolesnikov et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Biotechnology & Applied Microbiology

siRNA Nanoparticle Functionalization of Nanostructured Scaffolds Enables Controlled Multilineage Differentiation of Stem Cells

Morten O. Andersen et al.

MOLECULAR THERAPY (2010)

Review Multidisciplinary Sciences

The genetics of ageing

Cynthia J. Kenyon

NATURE (2010)

Article Neurosciences

SOX9 induces and maintains neural stem cells

Charlotte E. Scott et al.

NATURE NEUROSCIENCE (2010)

Review Gastroenterology & Hepatology

Colon cancer and the elderly: From screening to treatment in management of GI disease in the elderly

Peter R. Holt et al.

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2009)

Article Cell & Tissue Engineering

SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells

Jeffrey Biernaskie et al.

CELL STEM CELL (2009)

Article Developmental Biology

Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis

Ryan R. Driskell et al.

DEVELOPMENT (2009)

Article Developmental Biology

Multiple roles for Sox2 in the developing and adult mouse trachea

Jianwen Que et al.

DEVELOPMENT (2009)

Article Neurosciences

miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche

Li-Chun Cheng et al.

NATURE NEUROSCIENCE (2009)

Article Multidisciplinary Sciences

mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells

Jiaxi Zhou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Ophthalmology

Sox2 Plays a Role in the Induction of Amacrine and Muller Glial Cells in Mouse Retinal Progenitor Cells

Ya-Ping Lin et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2009)

Review Biochemistry & Molecular Biology

Stems cells and the pathways to aging and cancer

Derrick J. Rossi et al.

Article Cell & Tissue Engineering

Hair follicle stem cells are specified and function in early skin morphogenesis

Jonathan A. Nowak et al.

CELL STEM CELL (2008)

Review Oncology

Impact of aging on the biology of breast cancer

Christopher C. Benz

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2008)

Article Multidisciplinary Sciences

SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland

Teddy Fauquier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biotechnology & Applied Microbiology

Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts

Masato Nakagawa et al.

NATURE BIOTECHNOLOGY (2008)

Article Cell Biology

Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice

Lise Sofie Haug Nissen-Meyer et al.

JOURNAL OF CELL SCIENCE (2007)

Article Biochemistry & Molecular Biology

Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells

Annette P. Meeson et al.

EMBO JOURNAL (2007)

Review Cell Biology

Cellular senescence: when bad things happen to good cells

Judith Campisi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Neurosciences

Stem cell marker expression in the Bergmann glia population of the adult mouse brain

Virginie Sottile et al.

BRAIN RESEARCH (2006)

Article Developmental Biology

Satellite-cell pool size does matter: Defining the myogenic potency of aging skeletal muscle

Gabi Shefer et al.

DEVELOPMENTAL BIOLOGY (2006)

Article Cell Biology

SOX2 is a dose-dependent regulator of retinal neural progenitor competence

OV Taranova et al.

GENES & DEVELOPMENT (2006)

Review Cell Biology

Aging of mesenchymal stem cells

S Sethe et al.

AGEING RESEARCH REVIEWS (2006)

Article Biochemistry & Molecular Biology

Transcriptional regulation of Nanog by Oct4 and Sox2

DJ Rodda et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells

M Maruyama et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Cell Biology

Identification of a molecular signature of sarcopenia

PG Giresi et al.

PHYSIOLOGICAL GENOMICS (2005)

Review Neurosciences

SOX genes and neural progenitor identity

L Pevny et al.

CURRENT OPINION IN NEUROBIOLOGY (2005)

Article Cell Biology

Sox genes and cancer

C Dong et al.

CYTOGENETIC AND GENOME RESEARCH (2004)

Article Neurosciences

Vertebrate neurogenesis is counteracted by Sox1-3 activity

M Bylund et al.

NATURE NEUROSCIENCE (2003)

Article Neurosciences

SOX2 functions to maintain neural progenitor identity

V Graham et al.

NEURON (2003)

Article Biochemistry & Molecular Biology

Sox8 is a specific marker for muscle satellite cells and inhibits myogenesis

K Schmidt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Review Genetics & Heredity

Pairing SOX off with partners in the regulation of embryonic development

Y Kamachi et al.

TRENDS IN GENETICS (2000)