Platelet-Inspired Nanotherapeutics for Biomedical Applications

Platelets, as abundant corpuscles in the blood, are extensively involved in normal physiological processes and disease occurrence. Recently, remarkable progress in platelet based nanotherapeutics has been made, especially with the burgeoning fields of biotechnology and nanomedicine. Herein, we aim to provide an overview on platelet-inspired nano therapeutics for biomedical applications. First, the recent trends of biomimetic platelet-inspired nanotherapeutics are outlined, mainly including platelet membrane-camouflaged nanosystems, platelets loading with nanoparticles and platelet-mimicking nanocarriers. Then, the emerging nanotherapeutics for functional modulation of platelet aggregation, activation, and inhibition are discussed. Subsequently, platelet derivative-based nanotherapeutics are presented, including platelet extracellular vesicles and platelet polyphosphates. Finally, the clinical application prospects of these emerging nanotherapeutics are highlighted, with particular emphasis on their rationale, advantages, and challenges.

Automated summary

Platelets, as abundant corpuscles in the blood, play important roles in normal physiological processes and disease occurrence. In recent years, significant progress has been made in platelet-inspired nanotherapeutics, especially in the fields of biotechnology and nanomedicine. This article provides an overview of platelet-inspired nanotherapeutics for biomedical applications. It discusses the recent trends of biomimetic platelet-inspired nanosystems, the functional modulation of platelet aggregation, activation, and inhibition, platelet derivative-based nanotherapeutics, and the clinical application prospects of these emerging nanotherapeutics with their rationale, advantages, and challenges highlighted.