Journal
CLINICS IN PERINATOLOGY
Volume 42, Issue 1, Pages 133-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.clp.2014.10.012
Keywords
Necrotizing enterocolitis; Neonate; Bacteria; Virus; Fungi
Categories
Funding
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) [GM106143]
- Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD) [K08HD061607]
- Vanderbilt University Medical Center's Digestive Disease Research Center - NIH [P30DK058404]
- CTSA award from the National Center for Advancing Translational Sciences (NCATS) [UL1TR000445]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [K08HD061607] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [K08GM106143] Funding Source: NIH RePORTER
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Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency among premature infants. Although a large body of research has focused on understanding its pathogenesis, the exact mechanism has not been elucidated. Of particular interest is the potential causative role of infectious culprits in the development of NEC. A variety of reports describe bacterial, viral, and fungal infections occurring in association with NEC; however, no single organism has emerged as being definitively involved in NEC pathogenesis. In this review, the authors summarize the literature on infectious causes of NEC.
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