Journal
NATURE CANCER
Volume 4, Issue 1, Pages 7-8Publisher
NATURE PORTFOLIO
DOI: 10.1038/s43018-022-00501-y
Keywords
-
Categories
Ask authors/readers for more resources
Modulating T cell immune checkpoints and inhibiting chemokine receptors on myeloid-derived suppressor cells can change the highly suppressive tumor immune microenvironment in PDAC and lead to long-lasting complete responses in a mouse model. These findings offer a testable clinical treatment strategy for PDAC in humans.
Modulation of T cell immune checkpoints combined with inhibition of chemokine receptors on myeloid-derived suppressor cells can reprogram the highly suppressive tumor immune microenvironment of pancreatic ductal adenocarcinoma (PDAC), and generates durable complete responses in a PDAC mouse model. These results provide a testable clinical regimen for human PDAC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available