☆ 4.1 Article

Pan-targeted quantification of deep and comprehensive cancer serum proteome improves cancer detection

VIEW (2023)

Related references

Note: Only part of the references are listed.

Article Chemistry, Analytical

The Parallel Reaction Monitoring-Parallel Accumulation-Serial Fragmentation (prm-PASEF) Approach for Multiplexed Absolute Quantitation of Proteins in Human Plasma

Alexander Brzhozovskiy et al.

Summary: Mass spectrometry-based quantitative proteomic methods, such as prm-PASEF, are important tools for protein biomarker discovery and validation. This study demonstrated the use of prm-PASEF for absolute protein quantitation in human plasma, with improved sensitivity and a broad dynamic range. The prm-PASEF method showed excellent correlation with MRM, highlighting its suitability for absolute quantitative proteomics.

ANALYTICAL CHEMISTRY (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Proteomics technologies for cancer liquid biopsies

Zhiyong Ding et al.

Summary: The complexity of proteomes in liquid biopsy samples and the limitations of proteomic technologies compared to high-plex sequencing technologies have hindered the development of proteomics. However, novel protein technologies are urgently needed for biomarker discovery in cancer liquid biopsies. Traditional and innovative proteomic technologies are being rapidly developed and have greatly facilitated early detection, diagnosis, prognosis, and monitoring of cancer evolution.

MOLECULAR CANCER (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Noninvasive proteomic biomarkers for alcohol-related liver disease

Lili Niu et al.

Summary: This study used mass spectrometry analysis to investigate the liver and plasma proteomics of patients with alcohol-related liver disease. Noninvasive biomarkers associated with early stages of disease progression were identified. Machine learning models revealed that these biomarkers could accurately detect fibrosis and inflammation, and predict future liver-related events and all-cause mortality.

NATURE MEDICINE (2022)

Add to Collection

Article Chemistry, Analytical

Highly Multiplexed Targeted Proteomics Acquisition on a TIMS-QTOF

Antoine Lesur et al.

Summary: Targeted proteomics with high sensitivity is achieved through the detection of specific peptides and proteins in complex biological samples. By utilizing the prm-PASEF method with trapped ion mobility separation, over 200 peptides can be monitored in a 30-minute liquid chromatography separation, improving quantification accuracy in biological samples. Detection and quantification of isotope-labeled synthetic peptides with limits of quantification as low as 17.2 amol were achieved, demonstrating the reproducibility and accuracy of the method.

ANALYTICAL CHEMISTRY (2021)

Add to Collection

Review Peripheral Vascular Disease

APOA1: a Protein with Multiple Therapeutic Functions

Blake J. Cochran et al.

Summary: Apolipoprotein A1 has multiple cardioprotective functions and potential therapeutic benefits in diseases such as atherosclerosis, thrombosis, diabetes, cancer, and neurological disorders. The development of synthetic reconstituted HDL preparations that mimic the functions of APOA1 could lead to clinical applications.

CURRENT ATHEROSCLEROSIS REPORTS (2021)

Add to Collection

Article Oncology

Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set

E. A. Klein et al.

Summary: This study confirmed the feasibility of using the refined MCED test version as a screening tool, demonstrating high specificity and accuracy in predicting CSO, and detecting signals of various cancers.

ANNALS OF ONCOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

A proteomic atlas of senescence-associated secretomes for aging biomarker development

Nathan Basisty et al.

PLOS BIOLOGY (2020)

Add to Collection

Article Chemistry, Analytical

Protein-protein correlations based variable dimension expansion algorithm for high efficient serum biomarker discovery

Juanjuan Xie et al.

ANALYTICA CHIMICA ACTA (2020)

Add to Collection

Article Oncology

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

M. C. Liu et al.

ANNALS OF ONCOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease

Jakob M. Bader et al.

MOLECULAR SYSTEMS BIOLOGY (2020)

Add to Collection

Review Oncology

Non-Invasive Biomarkers for Early Detection of Breast Cancer

Jiawei Li et al.

CANCERS (2020)

Add to Collection

Article Cell Biology

A Systematic Investigation of the Malignant Functions and Diagnostic Potential of the Cancer Secretome

Jonathan L. Robinson et al.

CELL REPORTS (2019)

Add to Collection

Article Biochemical Research Methods

Potential early clinical stage colorectal cancer diagnosis using a proteomics blood test panel

Seong Beom Ahn et al.

CLINICAL PROTEOMICS (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Undulating changes in human plasma proteome profiles across the lifespan

Benoit Lehallier et al.

NATURE MEDICINE (2019)

Add to Collection

Article Medicine, Research & Experimental

Circulating proteomic panels for diagnosis and risk stratification of acute-on-chronic liver failure in patients with viral hepatitis B

Zeyu Sun et al.

THERANOSTICS (2019)

Add to Collection

Article Cardiac & Cardiovascular Systems

Proteomic Architecture of Human Coronary and Aortic Atherosclerosis

David M. Herrington et al.

CIRCULATION (2018)

Add to Collection

Review Urology & Nephrology

The Complexity and Heterogeneity of Monoclonal Immunoglobulin-Associated Renal Diseases

Sanjeev Sethi et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

Add to Collection

Article Multidisciplinary Sciences

Extracellular mRNA detected by molecular beacons in tethered lipoplex nanoparticles for diagnosis of human hepatocellular carcinoma

Xinmei Wang et al.

PLOS ONE (2018)

Add to Collection

Article Multidisciplinary Sciences

Detection and localization of surgically resectable cancers with a multi-analyte blood test

Joshua D. Cohen et al.

SCIENCE (2018)

Add to Collection

Article Oncology

Universal cancer screening: revolutionary, rational, and realizable

David A. Ahlquist

NPJ PRECISION ONCOLOGY (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Revisiting biomarker discovery by plasma proteomics

Philipp E. Geyer et al.

MOLECULAR SYSTEMS BIOLOGY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Plasma Proteome Database as a resource for proteomics research: 2014 update

Vishalakshi Nanjappa et al.

NUCLEIC ACIDS RESEARCH (2014)

Add to Collection

News Item Biochemical Research Methods

Targeted proteomics

Vivien Marx

NATURE METHODS (2013)

Add to Collection

Article Biochemical Research Methods

Parallel Reaction Monitoring for High Resolution and High Mass Accuracy Quantitative, Targeted Proteomics

Amelia C. Peterson et al.

MOLECULAR & CELLULAR PROTEOMICS (2012)

Add to Collection

Review Biochemical Research Methods

Selected reaction monitoring-based proteomics: workflows, potential, pitfalls and future directions

Paola Picotti et al.

NATURE METHODS (2012)

Add to Collection

© Peeref 2019-2024. All rights reserved.