Nanocoating of CsgA protein for enhanced cell adhesion and proliferation

Immune rejection, poor biocompatibility and cytotoxicity have seriously stalled the widespread appli-cation of biometallic materials. To overcome these problems, biometallic materials with fast and suf-ficient osseointegration, antibacterial properties and long-term stability have attracted the attention of researchers worldwide. Surface modification is currently used as a general strategy to develop material coatings that will overcome these challenging requirements and achieve the successful performance of implants. In this study, we proposed a substrate surface-modification strategy based on biofilm CsgA pro-teins that promote rapid cell attachment, proliferation, and stabilization of the cytoskeleton. CsgA-based nano-coating is easy to fabricate and has superior performance, which is expected to expand the appli-cation of medical implants.(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Automated summary

Immune rejection, poor biocompatibility and cytotoxicity hamper the widespread use of biometallic materials. Surface modification has been employed as a general strategy to develop material coatings that can overcome these challenges and achieve successful implant performance. In this study, a substrate surface-modification strategy based on biofilm CsgA proteins was proposed, which promotes rapid cell attachment, proliferation, and stabilization of the cytoskeleton. The CsgA-based nano-coating is easy to fabricate and exhibits superior performance, which is expected to expand the application of medical implants.