A near-infrared fluorescent nanoprobe for senescence-associated β-galactosidase sensing in living cells

A near-infrared fluorescent nanoprobe based on semiconducting polymer nanoparticles (SPNs) for the detection of senescence-associated beta-gal (SA-beta-gal) is developed. Benefiting from the intrinsic lysosome-locating feature, this probe can be successfully used for the visualization of SA-beta-gal in living cells.

Automated summary

A near-infrared fluorescent nanoprobe based on semiconducting polymer nanoparticles (SPNs) is developed for detecting senescence-associated beta-gal (SA-beta-gal). This probe can visualize SA-beta-gal in living cells due to its inherent lysosome-locating feature.