Iridium-catalyzed selective amination of B(4)-H for the synthesis of o-carborane-fused indolines

An iridium-catalyzed selective amination of B(4)-H via dehydrogenative cross-coupling of B-H/N-H bonds for the synthesis of o-carborane-fused indolines has been developed for the first time. Various types of unprecedented o-carborane-fused indolines have been synthesized, which would be potential candidates for applications in drug discovery, pharmaceutical chemistry and functional materials. This work offers a valuable reference for the designing and synthesis of o-carborane-fused heterocycles.

Automated summary

An effective method for the selective amination of B(4)-H via dehydrogenative cross-coupling of B-H/N-H bonds to synthesize o-carborane-fused indolines has been developed. Various novel o-carborane-fused indolines have been successfully synthesized, which have great potential for applications in drug discovery, pharmaceutical chemistry, and functional materials. This work provides valuable insights for the design and synthesis of o-carborane-fused heterocycles.