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Modulating Glycolysis to Improve Cancer Therapy

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Summary: The study suggests that high mitochondrial ATP production is a new therapeutic target for cancer treatment, isolating metabolically fit cancer cells with enhanced stem-like properties and invasive abilities. By regulating mitochondrial ATP-synthase, prevention of metastasis in cancer cells is possible.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation

Irini Skaripa-Koukelli et al.

Summary: TNBC is an aggressive form of breast cancer lacking hormone receptors and ERBB2 gene amplification, posing challenges in treatment options. This study demonstrates that targeting MCT1 with 3BP inhibits glycolysis in TNBC cells and enhances cytotoxic effect in combination with radiotherapy, offering a promising strategy for treating glycolytic tumors.

CANCER & METABOLISM (2021)

Article Chemistry, Medicinal

Macrosphelide A Exhibits a Specific Anti-Cancer Effect by Simultaneously Inactivating ENO1, ALDOA, and FH

Kyoung Song et al.

Summary: MSPA exhibits anti-cancer effects by simultaneously targeting ENO1, ALDOA, and FH enzymes, reducing glucose consumption and lactate release, inhibiting cancer cell proliferation, and inducing apoptosis.

PHARMACEUTICALS (2021)

Review Biochemistry & Molecular Biology

The Glycolytic Pathway as a Target for Novel Onco-Immunology Therapies in Pancreatic Cancer

Claudia Curcio et al.

Summary: Pancreatic ductal adenocarcinoma (PDA) is characterized by unrestrained progression, invasiveness, and treatment resistance, with altered cellular metabolism in the hypoxic tumor microenvironment (TME) leading to immunosuppression. Overexpressed or mutated glycolytic enzymes may serve as potential immunological targets in anti-PDA therapeutic strategies.

MOLECULES (2021)

Review Oncology

The complex Integration of T-cell Metabolism and Immunotherapy

Matthew Z. Madden et al.

Summary: The metabolic reprogramming of T cells plays a crucial role in their function and fate, but is disrupted in cancer, potentially suppressing antitumor immunity. Therefore, stimulating effector T cell metabolism and enhancing cancer immunotherapy are challenges and opportunities that need to be addressed.

CANCER DISCOVERY (2021)

Article Biochemistry & Molecular Biology

The PFKFB3 Inhibitor AZ67 Inhibits Angiogenesis Independently of Glycolysis Inhibition

Besa Emini Veseli et al.

Summary: The study aimed to investigate the effects of PFKFB3 inhibition on angiogenesis using the small molecule AZ67. It was found that AZ67 could disrupt angiogenesis independently of glycolysis inhibition, even though it did not significantly affect certain aspects of cellular metabolism.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Immunology

Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4+ T Cells in Type 1 Diabetes

Christina P. Martins et al.

Summary: In T1D, CD4(+) T cells can be targeted and their metabolic reprogramming altered by using the small molecule PFK15 as a competitive inhibitor. This approach delayed diabetes onset in animal models, with a significant percentage of animals maintaining normal blood glucose levels. The results demonstrate a novel therapeutic strategy to control aberrant T cell responses by exploiting metabolic reprogramming in T1D.

FRONTIERS IN IMMUNOLOGY (2021)

Review Oncology

Defueling the cancer: ATP synthase as an emerging target in cancer therapy

Ting Wang et al.

Summary: Reprogramming of cellular metabolism is a hallmark of cancer, with high expression of ATP synthase playing a role. ATP synthase is involved in angiogenesis, tumorigenesis, and metastasis of cancer.

MOLECULAR THERAPY-ONCOLYTICS (2021)

Review Oncology

Glucose Transporters as a Target for Anticancer Therapy

Monika Pliszka et al.

Summary: Cancer cells prefer glycolysis for ATP production due to hypoxia; overexpression of glucose transporters promotes carcinogenesis and may have beneficial effects; inhibiting glucose transporters could be a treatment method for cancer patients.

CANCERS (2021)

Article Oncology

PD-L1 Overexpression, SWI/SNF Complex Deregulation, and Profound Transcriptomic Changes Characterize Cancer-Dependent Exhaustion of Persistently Activated CD4+ T Cells

Iga Jancewicz et al.

Summary: Tumors induce inhibitory signals to prevent attacks from tumor-infiltrating lymphocytes (TILs), leading to dysfunction and apoptosis of effector T cells. Continuous stimulation causes TILs to become exhausted, unable to kill tumor cells and produce cytokines, resulting in immune escape of cancer cells. This study suggests a potential role for EZH2 inhibitors as immunomodulators in cancer treatment.

CANCERS (2021)

Article Cell Biology

Inhibition of Metabolism as a Therapeutic Option for Tamoxifen-Resistant Breast Cancer Cells

Friederike Steifensand et al.

Summary: Increased glucose requirement and upregulated glutaminolysis play crucial roles in cancer cell survival, making combined metabolic treatments a potentially effective strategy for improving therapy outcomes in estrogen receptor alpha-positive breast cancer.

CELLS (2021)

Review Cell Biology

Glucose Metabolism and Glucose Transporters in Breast Cancer

Eunah Shin et al.

Summary: Breast cancer, the most common malignancy in women worldwide, is closely associated with glucose metabolism, with high expressions of glucose metabolism-related enzymes and transporters. The tumor microenvironment of breast cancer also involves various stromal cells, contributing to the heterogeneous metabolic status of the disease.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Dual Blockade of Lactate/GPR81 and PD-1/PD-L1 Pathways Enhances the Anti-Tumor Effects of Metformin

Shaomeng Chen et al.

Summary: This study demonstrates the synergistic effects of lactate/GPR81 blockade and metformin in inhibiting cancer cell growth, as well as enhancing immune cell functions and impacting PD-1 expression. The dual blockade strategy significantly enhances the anti-tumor effects of metformin, potentially leading to tumor regression.

BIOMOLECULES (2021)

Review Immunology

Metabolic barriers to cancer immunotherapy

Kristin DePeaux et al.

Summary: The tumour microenvironment creates barriers that suppress immune responses, including physical barriers, recruitment of suppressive immune cells, and upregulation of inhibitory ligands on tumour cells. Therapies targeting metabolic restrictions in the tumour microenvironment show promise for combination therapies against various types of cancer.

NATURE REVIEWS IMMUNOLOGY (2021)

Review Immunology

Top 10 Challenges in Cancer Immunotherapy

Priti S. Hegde et al.

IMMUNITY (2020)

Review Biochemistry & Molecular Biology

Photodynamic Therapy for Cancer: What's Past is Prologue

Michael R. Hamblin

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2020)

Review Oncology

Overcoming Endocrine Resistance in Breast Cancer

Ariella B. Hanker et al.

CANCER CELL (2020)

Article Medicine, Research & Experimental

Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability

Sonia Guedan et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Cell Biology

Mitochondrial Metabolism as a Target for Cancer Therapy

Karthik Vasan et al.

CELL METABOLISM (2020)

Article Medicine, Research & Experimental

MEK activation modulates glycolysis and supports suppressive myeloid cells in TNBC

Derek A. Franklin et al.

JCI INSIGHT (2020)

Review Biochemistry & Molecular Biology

Power of two: combination of therapeutic approaches involving glucose transporter (GLUT) inhibitors to combat cancer

Kalpana Tilekar et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

Review Biochemistry & Molecular Biology

Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

Jackie E. Bader et al.

MOLECULAR CELL (2020)

Article Immunology

Disturbed mitochondrial dynamics in CD8+TILs reinforce T cell exhaustion

Yi-Ru Yu et al.

NATURE IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

Qin Wu et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

MEK reduces cancer-specific PpIX accumulation through the RSK-ABCB1 and HIF-1α-FECH axes

Vipin Shankar Chelakkot et al.

SCIENTIFIC REPORTS (2020)

Review Cell Biology

Extracellular ATP: A Feasible Target for Cancer Therapy

Valentina Vultaggio-Poma et al.

CELLS (2020)

Review Cell Biology

Cancer cell metabolic reprogramming: a keystone for the response to immunotherapy

Michael Cerezo et al.

CELL DEATH & DISEASE (2020)

Article Endocrinology & Metabolism

An enolase inhibitor for the targeted treatment of ENO1-deleted cancers

Yu-Hsi Lin et al.

NATURE METABOLISM (2020)

Article Endocrinology & Metabolism

Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy

Ramon I. Klein Geltink et al.

NATURE METABOLISM (2020)

Review Biochemistry & Molecular Biology

Phenformin as an Anticancer Agent: Challenges and Prospects

Ma Eugenia Garcia Rubino et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Chemistry, Medicinal

The progress and development of GLUT1 inhibitors targeting cancer energy metabolism

Ying Meng et al.

FUTURE MEDICINAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells

Siyuan Yan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

Robert D. Leone et al.

SCIENCE (2019)

Article Pharmacology & Pharmacy

The Combination of MK-2206 and WZB117 Exerts a Synergistic Cytotoxic Effect Against Breast Cancer Cells

Yu-Liang Li et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Endocrinology & Metabolism

Crosstalk between Estrogen Signaling and Breast Cancer Metabolism

Eylem Kulkoyluoglu-Cotul et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)

Article Multidisciplinary Sciences

Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin

A. Flores et al.

NATURE COMMUNICATIONS (2019)

Review Endocrinology & Metabolism

Metabolic Dysregulation Controls Endocrine Therapy-Resistant Cancer Recurrence and Metastasis

Malachi A. Blundon et al.

ENDOCRINOLOGY (2019)

Review Oncology

The dark side of glucose transporters in prostate cancer: Are they a new feature to characterize carcinomas?

Pedro Gonzalez-Menendez et al.

INTERNATIONAL JOURNAL OF CANCER (2018)

Article Biotechnology & Applied Microbiology

Enhancement of anticancer activity by silibinin and paclitaxel combination on the ovarian cancer

Fatima Pashaei-Asl et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

Editorial Material Oncology

Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues

Annamarie E. Allen et al.

CANCER CELL (2018)

Review Cell Biology

The Science and Translation of Lactate Shuttle Theory

George A. Brooks

CELL METABOLISM (2018)

Article Medicine, General & Internal

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

S. L. Maude et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Multidisciplinary Sciences

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth

Ilenia Pacella et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Exosome-mediated breast cancer chemoresistance via miR-155 transfer

Juliana Carvalho Santos et al.

SCIENTIFIC REPORTS (2018)

Article Medicine, Research & Experimental

Enhancement of Cancer-Specific Protoporphyrin IX Fluorescence by Targeting Oncogenic Ras/MEK Pathway

Ema Yoshioka et al.

THERANOSTICS (2018)

Article Biochemistry & Molecular Biology

GLUT1 protects prostate cancer cells from glucose deprivation-induced oxidative stress

Pedro Gonzalez-Menendez et al.

REDOX BIOLOGY (2018)

Meeting Abstract Oncology

Targeting glycolysis enzyme, PFKFB3, in endocrine therapy resistant breast cancers

Surojeet Sengupta et al.

CANCER RESEARCH (2018)

Article Pharmacology & Pharmacy

Effects of metformin on the PI3K/AKT/FOXO1 pathway in anaplastic thyroid Cancer cell lines

Zahra Nozhat et al.

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

Article Biochemistry & Molecular Biology

Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors

Yang Gao et al.

CELL CHEMICAL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Alpha-Enolase (ENO1), a potential target in novel immunotherapies

Paola Cappello et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2017)

Review Biochemistry & Molecular Biology

The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer

Dimakatso Alice Senthebane et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Biochemistry & Molecular Biology

α-enolase promotes tumorigenesis and metastasis via regulating AMPK/mTOR pathway in colorectal cancer

Panpan Zhan et al.

MOLECULAR CARCINOGENESIS (2017)

Article Multidisciplinary Sciences

Chromatin states define tumour-specific T cell dysfunction and reprogramming

Mary Philip et al.

NATURE (2017)

Article Medicine, General & Internal

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years

Hongchao Pan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Medicine, Research & Experimental

Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy

Christopher A. Klebanoff et al.

JCI INSIGHT (2017)

Review Cell Biology

Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy

Rigel J. Kishton et al.

CELL METABOLISM (2017)

Review Oncology

Therapeutic strategies targeting cancer stem cells

Go J. Yoshida et al.

CANCER SCIENCE (2016)

Article Oncology

Linking Cancer Metabolism to DNA Repair and Accelerated Senescence

Elena V. Efimova et al.

MOLECULAR CANCER RESEARCH (2016)

Article Biochemistry & Molecular Biology

Curcumin suppresses 4-hydroxytamoxifen resistance in breast cancer cells by targeting SLUG/Hexokinase 2 pathway

Chong Geng et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Oncology

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming

Young Chan Chae et al.

CANCER CELL (2016)

Editorial Material Oncology

Glycoholics Anonymous: Cancer Sobers Up with mTORC1

Vivian Fu et al.

CANCER CELL (2016)

Article Oncology

Inhibition of Glut1 by WZB117 sensitizes radioresistant breast cancer cells to irradiation

Fei Zhao et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2016)

Article Oncology

PDT: What's Past Is Prologue

Keith A. Cengel et al.

CANCER RESEARCH (2016)

Article Biochemistry & Molecular Biology

PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

Ninel Azoitei et al.

MOLECULAR CANCER (2016)

Article Biochemistry & Molecular Biology

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Aaron Boudreau et al.

NATURE CHEMICAL BIOLOGY (2016)

Review Biochemistry & Molecular Biology

The Warburg Effect: How Does it Benefit Cancer Cells?

Maria V. Liberti et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

Article Biotechnology & Applied Microbiology

Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system: evidence from 16 cohort studies

Jiayuan Wu et al.

ONCOTARGETS AND THERAPY (2016)

Review Multidisciplinary Sciences

Fundamentals of cancer metabolism

Ralph J. DeBerardinis et al.

SCIENCE ADVANCES (2016)

Article Biochemistry & Molecular Biology

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

Ping-Chih Ho et al.

Article Biochemistry & Molecular Biology

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

Chih-Hao Chang et al.

Article Biochemistry & Molecular Biology

Anti-tumor effects of progesterone in human glioblastoma multiforme: Role of PI3K/Akt/mTOR signaling

Fahim Atif et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Cross-talk between ER and HER2 regulates c-MYC-mediated glutamine metabolism in aromatase inhibitor resistant breast cancer cells

Zhike Chen et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2015)

Review Biochemistry & Molecular Biology

Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications

Rebecca Kohnken et al.

MOLECULAR CANCER (2015)

Article Multidisciplinary Sciences

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

Nikolaos Patsoukis et al.

NATURE COMMUNICATIONS (2015)

Article Oncology

Targeting lactate transport suppresses in vivo breast tumour growth

Filipa Morais-Santos et al.

ONCOTARGET (2015)

Article Endocrinology & Metabolism

Dietary Iron Controls Circadian Hepatic Glucose Metabolism Through Heme Synthesis

Judith A. Simcox et al.

DIABETES (2015)

Article Medicine, Research & Experimental

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

Valerie A. Gerriets et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Oncology

Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma

Robert T. Wicks et al.

NEURO-ONCOLOGY (2015)

Article Multidisciplinary Sciences

Synergistic Anti-Cancer Effect of Phenformin and Oxamate

W. Keith Miskimins et al.

PLOS ONE (2014)

Article Biochemistry & Molecular Biology

Energy metabolism targeted drugs synergize with photodynamic therapy to potentiate breast cancer cell death

Xiaolan Feng et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2014)

Editorial Material Cell Biology

Dual inhibition of autophagy and the AKT pathway in prostate cancer

Francois Lamoureux et al.

AUTOPHAGY (2013)

Article Biochemistry & Molecular Biology

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

Katrien De Bock et al.

Review Cell Biology

Role of Endothelial Cell Metabolism in Vessel Sprouting

Katrien De Bock et al.

CELL METABOLISM (2013)

Article Gastroenterology & Hepatology

Vaccination With ENO1 DNA Prolongs Survival of Genetically Engineered Mice With Pancreatic Cancer

Paola Cappello et al.

GASTROENTEROLOGY (2013)

Article Medicine, Research & Experimental

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

Madhusudhanan Sukumar et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Medicine, Research & Experimental

Oncometabolites: linking altered metabolism with cancer

Ming Yang et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Genetics & Heredity

ESR1 ligand-binding domain mutations in hormone-resistant breast cancer

Weiyi Toy et al.

NATURE GENETICS (2013)

Article Genetics & Heredity

Activating ESR1 mutations in hormone-resistant metastatic breast cancer

Dan R. Robinson et al.

NATURE GENETICS (2013)

Article Oncology

Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation

Anna N. Mendler et al.

INTERNATIONAL JOURNAL OF CANCER (2012)

Article Multidisciplinary Sciences

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

Eric T. Clambey et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Oncology

Photodynamic Therapy of Cancer: An Update

Patrizia Agostinis et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2011)

Article Medicine, General & Internal

GLUT1 expression in malignant tumors and its use as an immunodiagnostic marker

Katia C. Carvalho et al.

CLINICS (2011)

Article Oncology

Efficacy of RNAi targeting of pyruvate kinase M2 combined with cisplatin in a lung cancer model

Wenhao Guo et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2011)

Article Immunology

The Liver Kinase B1 Is a Central Regulator of T Cell Development, Activation, and Metabolism

Nancie J. MacIver et al.

JOURNAL OF IMMUNOLOGY (2011)

Review Biotechnology & Applied Microbiology

Targeting cancer metabolism: a therapeutic window opens

Matthew G. Vander Heiden

NATURE REVIEWS DRUG DISCOVERY (2011)

Article Multidisciplinary Sciences

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

Qian Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Cell Biology

Glyoxalase in tumourigenesis and multidrug resistance

Paul J. Thornalley et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2011)

Review Biochemistry & Molecular Biology

3-Bromopyruvate: A New Targeted Antiglycolytic Agent and a Promise for Cancer Therapy

S. Ganapathy-Kanniappan et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2010)

Article Multidisciplinary Sciences

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

Anne Le et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Oncology

Targeting metabolic transformation for cancer therapy

Daniel A. Tennant et al.

NATURE REVIEWS CANCER (2010)

Article Radiology, Nuclear Medicine & Medical Imaging

Evaluation of the Role of Hexokinase Type II in Cellular Proliferation and Apoptosis Using Human Hepatocellular Carcinoma Cell Lines

Keun Jae Ahn et al.

JOURNAL OF NUCLEAR MEDICINE (2009)

Article Multidisciplinary Sciences

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

Erika L. Pearce et al.

NATURE (2009)

Article Multidisciplinary Sciences

mTOR regulates memory CD8 T-cell differentiation

Koichi Araki et al.

NATURE (2009)

Review Biotechnology & Applied Microbiology

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

Dunyaporn Trachootham et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

Review Multidisciplinary Sciences

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Matthew G. Vander Heiden et al.

SCIENCE (2009)

Review Oncology

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

David B. Shackelford et al.

NATURE REVIEWS CANCER (2009)

Review Cell Biology

The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation

Ralph J. DeBerardinis et al.

CELL METABOLISM (2008)

Article Immunology

Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway

Hiroaki Shime et al.

JOURNAL OF IMMUNOLOGY (2008)

Article Biochemistry & Molecular Biology

Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II

S. Miyamoto et al.

CELL DEATH AND DIFFERENTIATION (2008)

Review Oncology

Hypoxia, HIF1 and glucose metabolism in the solid tumour

Nicholas C. Denko

NATURE REVIEWS CANCER (2008)

Article Immunology

Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+T regulatory cells

Heather Kopf et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2007)

Review Oncology

Non-[F-18]FDG PET in clinical oncology

Ashley M. Groves et al.

LANCET ONCOLOGY (2007)

Article Biochemistry & Molecular Biology

Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1α

C Handschin et al.

Review Oncology

Why do cancers have high aerobic glycolysis?

RA Gatenby et al.

NATURE REVIEWS CANCER (2004)

Article Oncology

Glycolysis and glucose transporter 1 as markers of response to hormonal therapy in breast cancer

D Rivenzon-Segal et al.

INTERNATIONAL JOURNAL OF CANCER (2003)

Article Engineering, Biomedical

Scavengers protection of cells against ALA-based photodynamic therapy-induced damage

C Perotti et al.

LASERS IN MEDICAL SCIENCE (2002)