Recent progress in synthesis and application of furoxan

This review highlights recent developments in the synthesis and application of furoxan. The chemistry of furoxan is relatively underdeveloped compared to that of other heterocycles owing to its difficult synthesis, which is ascribed to the labile nature of this molecule under various reaction conditions. Nevertheless, recent studies have conducted a variety of bond-forming reactions on the furoxan ring via a post-ring introduction of substituents (PRIS) strategy. This strategy enables the synthesis of furoxan molecules of interest more directly than the conventional methods that rely on the pre-installation of substituents on the furoxan ring precursors. In this review, the PRIS strategy for furoxan synthesis is classified and discussed according to the type of bond formed. Additionally, recent progress in the application of furoxan molecules, predominantly facilitated by the development of new synthetic methods, is covered in this review.

Automated summary

This review focuses on the recent advances in the synthesis and application of furoxan. Due to its labile nature, the synthesis of furoxan has been challenging compared to other heterocycles. However, recent studies have successfully employed the post-ring introduction of substituents (PRIS) strategy to form bonds on the furoxan ring, enabling more direct synthesis of desired furoxan molecules. This review classifies and discusses the PRIS strategy based on the type of bond formed and covers the recent progress in the application of furoxan molecules facilitated by new synthetic methods.