4.7 Review

Modern Approaches for the Development of New Herbicides Based on Natural Compounds

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Action Mode of the Mycotoxin Patulin as a Novel Natural Photosystem II Inhibitor

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Summary: This study identified the mycotoxin patulin (PAT) as a new natural photosystem II (PSII) inhibitor with herbicidal activity against Ageratina adenophora. PAT significantly reduces photosynthetic efficiency by blocking electron transport in PSII, suggesting its potential as a bioherbicide or template scaffold for discovering novel derivatives.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Agriculture, Multidisciplinary

Structure Simplification of Natural Products as a Lead Generation Approach in Agrochemical Discovery

Thomas C. Sparks et al.

Summary: Natural products have a long history as sources of compounds for crop protection, and have also served as models for the discovery and development of synthetic crop protection compounds. The simplification of natural product structures is key for the development of future agrochemicals focused on fungicides, herbicides, and insecticides.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Environmental Sciences

Phytotoxicity test in check: Proposition of methodology for comparison of different method adaptations usually used worldwide

Pablo Machado Mendes et al.

Summary: Seed germination tests are widely used to indicate toxicity levels in samples, with lettuce being a main indicative species due to its high sensitivity. However, there is a lack of standardization worldwide, leading to variations in phytotoxicity tests. The proposed methodology aims to compare these variations globally, providing a standardized approach for comparing phytotoxicity levels across regions.

JOURNAL OF ENVIRONMENTAL MANAGEMENT (2021)

Article Agronomy

Design, synthesis, and herbicidal activity of novel phenoxypyridine derivatives containing natural product coumarin

Li-Xia Zhao et al.

Summary: The study focused on designing and synthesizing novel PPO inhibitor herbicides by linking a diphenylether pyridine bioisostere structure to substituted coumarins. A total of 21 compounds were synthesized and characterized, with compound IV-6 showing better herbicidal activity in greenhouse and field experiments compared to the commercial herbicide oxyfluorfen.

PEST MANAGEMENT SCIENCE (2021)

Article Agronomy

Systematic, small-scale screening with Arabidopsis reveals herbicides synergies that extend to lettuce

Kirill Sukhoverkov et al.

Summary: Our study demonstrates that screening herbicide mixtures against Arabidopsis thaliana is an efficient method for identifying rare herbicide synergies. We found five synergies, including three new combinations, suggesting that synergy may be a class-specific phenomenon.

PEST MANAGEMENT SCIENCE (2021)

Review Agronomy

What makes a molecule a pre- or a post-herbicide - how valuable are physicochemical parameters for their design?

Hansjorg Kraehmer et al.

Summary: Pre-emergence herbicides are taken up by seeds before germination and by roots, hypocotyls, cotyledons, coleoptiles or leaves before emergence, while post-emergence herbicides are primarily absorbed by foliage and stems. The metabolic conversion of herbicides after plant uptake is crucial for some compound classes. The cellular site of action plays a major role in the effectiveness of herbicides on plants.

PEST MANAGEMENT SCIENCE (2021)

Article Multidisciplinary Sciences

Comprehensive machine learning based study of the chemical space of herbicides

Davor Orsolic et al.

Summary: The study utilized Random Forest modeling to build predictive models and provide a comprehensive characterization of structure-activity relationships for herbicides based on their MoAs and weed selectivity. A virtual screening platform was proposed for evaluating small weight molecules for their phytotoxic properties by combining predictive models with herbicide-likeness rules defined by selected molecular features.

SCIENTIFIC REPORTS (2021)

Article Multidisciplinary Sciences

Herbicidal properties of antihypertensive drugs: calcium channel blockers

Hannan Safiyyah Tan Sian Hui Abdullah et al.

Summary: Herbicide resistance is a global issue, prompting researchers to search for new modes of action. A study on thiazolo[3,2-a]pyrimidines derivatives found that compound c demonstrated effective herbicidal activity against several weeds and different levels of tolerance in various crops, suggesting its potential as a template for developing new herbicides.

SCIENTIFIC REPORTS (2021)

Review Chemistry, Multidisciplinary

Web-Based Quantitative Structure-Activity Relationship Resources Facilitate Effective Drug Discovery

Yu-Liang Wang et al.

Summary: Traditional drug discovery is limited by high costs and long cycles, while QSAR methods save costs and make it easier to evaluate compound activity. Surveying mainstream web tools for QSAR modeling can help researchers choose appropriate tools for developing QSAR models.

TOPICS IN CURRENT CHEMISTRY (2021)

Article Engineering, Chemical

Alginate Nanohydrogels as a Biocompatible Platform for the Controlled Release of a Hydrophilic Herbicide

Fiora Artusio et al.

Summary: The large-scale use of volatile and highly water-soluble pesticides for crop protection can have negative impacts on the environment. Utilizing alginate nanoparticles to encapsulate herbicides can promote sustained release and improve pesticide efficiency, reducing environmental pollution.

PROCESSES (2021)

Article Agronomy

Weed Control Efficacy and Crop-Weed Selectivity of a New Bioherbicide WeedLock

Mahmudul Hasan et al.

Summary: Plant-based bioherbicide WeedLock demonstrated effective weed control and non-selectivity in both glasshouse and field conditions. Compared to chemical herbicides, WeedLock showed similar efficacy to glyphosate isopropyl-amine for Ageratum conyzoides L. and displayed sustainable weed control potential in the experiments.

AGRONOMY-BASEL (2021)

Article Agronomy

Development of an Agar Bioassay Sensitivity Test in Alopecurus myosuroides for the Pre-Emergence Herbicides Cinmethylin and Flufenacet

Miriam H. Messelhauser et al.

Summary: This study developed an agar quick test to determine sensitivity differences in Alopecurus myosuroides to pre-emergence herbicides and compared the results with a standardized whole plant pot bioassay. The majority of populations confirmed the results of the bioassay sensitivity tests, demonstrating the potential for a faster and promising test system.

AGRONOMY-BASEL (2021)

Article Infectious Diseases

Dual Agents: Fungal Macrocidins and Synthetic Analogues with Herbicidal and Antibiofilm Activities

Laura Treiber et al.

Summary: Eight analogues of bioherbicides were synthesized and tested, with some showing high herbicidal activity against plants, inhibiting bacterial biofilm growth, and dispersing preformed biofilms. Two compounds showed promise as potential anti-biofilm agents with minimal cytotoxicity.

ANTIBIOTICS-BASEL (2021)

Review Plant Sciences

Bioherbicides: An Eco-Friendly Tool for Sustainable Weed Management

Mahmudul Hasan et al.

Summary: Integrated weed management, including the use of bioherbicides, is a promising strategy for sustainable agriculture. Bioherbicides disrupt weed growth by affecting cell membrane integrity and important biochemical processes.

PLANTS-BASEL (2021)

Article Multidisciplinary Sciences

Microencapsulation of pendimethalin with polyurethane-urea and determination of its stability

Hatice Yilmaz et al.

Summary: In this study, pendimethalin was encapsulated using interfacial polymerization method, and the characteristics of the produced microcapsules were investigated. It was found that capsules containing ethyl glycol in the wall structure had the highest stability, while capsules containing PEG-400 had the highest encapsulation efficiency.

JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE (2021)

Article Chemistry, Multidisciplinary

Chitosan/tripolyphosphate nanoformulation carrying paraquat: insights on its enhanced herbicidal activity

Montcharles S. Pontes et al.

Summary: This study investigated the target effect of paraquat-loaded chitosan/tripolyphosphate nanoparticles on photosystem I, revealing a significant decrease in lipid peroxidation, photooxidizable P700 reaction centre content, and NADPH/NADP(+) ratio levels in spinach leaf tissue exposed to the nanoherbicide compared to non-encapsulated herbicide. Molecular docking results showed a preferential disposition of the herbicide near FAD and Glu312. The findings suggest that the redox behavior of paraquat may play a key role in enhancing the efficiency of nanoherbicides at the target binding site.

ENVIRONMENTAL SCIENCE-NANO (2021)

Article Chemistry, Multidisciplinary

Improved herbicide discovery using physico-chemical rules refined by antimalarial library screening

Kirill V. Sukhoverkov et al.

Summary: By exploiting the evolutionary relationship between Plasmodium falciparum and plants, a novel herbicide compound, MMV1206386, with potency comparable to commercial herbicides and a new mode of action was discovered. Weighted rules were shown to be effective in herbicide discovery programs.

RSC ADVANCES (2021)

Article Agronomy

Bioassay-guided isolation of phytotoxins from three Salvia species

Claudia T. A. da Cruz-Silva et al.

Summary: This study found that the abietane diterpenes tanshinone I and tanshinone IIA in Salvia miltiorrhiza have strong phytotoxicity, inhibiting the growth of various plants. Their level of phytotoxicity is comparable to some commercial herbicides.

ALLELOPATHY JOURNAL (2021)

Article Food Science & Technology

Stability of Mycotoxins in Individual Stock and Multi-Analyte Standard Solutions

Mariya Kiseleva et al.

TOXINS (2020)

Article Plant Sciences

Novel Action Targets of Natural Product Gliotoxin in Photosynthetic Apparatus

Yanjing Guo et al.

FRONTIERS IN PLANT SCIENCE (2020)

Review Agronomy

An ecological future for weed science to sustain crop production and the environment. A review

Chloe MacLaren et al.

AGRONOMY FOR SUSTAINABLE DEVELOPMENT (2020)

Article Plant Sciences

A novel insight into the mode of action of glufosinate: how reactive oxygen species are formed

Hudson K. Takano et al.

PHOTOSYNTHESIS RESEARCH (2020)

Article Agricultural Engineering

Formulation and assessment of nano-encapsulated bioherbicides based on biopolymers and essential oil

Azin Taban et al.

INDUSTRIAL CROPS AND PRODUCTS (2020)

Article Biotechnology & Applied Microbiology

Herbicidal efficacy of harzianums produced by the biofertilizer fungus,Trichoderma brevicompactum

Miaomiao Yin et al.

AMB EXPRESS (2020)

Article Agronomy

Development of a Solid Bioherbicide Formulation by Spray Drying Technology

Thiago C. de Almeida et al.

AGRICULTURE-BASEL (2020)

Review Agronomy

Glufosinate-ammonium: a review of the current state of knowledge

Hudson K. Takano et al.

PEST MANAGEMENT SCIENCE (2020)

Review Biotechnology & Applied Microbiology

Engineered biosynthesis of thaxtomin phytotoxins

Linqi Wang et al.

CRITICAL REVIEWS IN BIOTECHNOLOGY (2020)

Article Multidisciplinary Sciences

Evolution of generalist resistance to herbicide mixtures reveals a trade-off in resistance management

David Comont et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Current Contributions of Organofluorine Compounds to the Agrochemical Industry

Yuta Ogawa et al.

ISCIENCE (2020)

Review Plant Sciences

Proving the Mode of Action of Phytotoxic Phytochemicals

Stephen O. Duke et al.

PLANTS-BASEL (2020)

Review Plant Sciences

Phytotoxic Effects and Mechanism of Action of Essential Oils and Terpenoids

Mercedes Verdeguer et al.

PLANTS-BASEL (2020)

Article Biotechnology & Applied Microbiology

Synthesis, phytotoxic evaluation and in silico studies for the development of novel natural products-inspired herbicides

Ricardo P. Rodrigues et al.

BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY (2020)

Article Biochemistry & Molecular Biology

Predicting herbicide movement across semi-permeable membranes using three phase partitioning

Hudson K. Takano et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2019)

Article Agricultural Engineering

Herbicidal activities of compounds isolated from the medicinal plant Piper sarmentosum

Gang Feng et al.

INDUSTRIAL CROPS AND PRODUCTS (2019)

Article Biotechnology & Applied Microbiology

Sense and nonsense of the secondary metabolites data requirements in the EU for beneficial microbial control agents

Jacqueline W. A. Scheepmaker et al.

BIOLOGICAL CONTROL (2019)

Article Materials Science, Biomaterials

Biodegradable poly(3-hydroxybutyrate-co-4-hydroxybutyrate) microcapsules for controlled release of trifluralin with improved photostability and herbicidal activity

Lidong Cao et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

Review Plant Sciences

Current Status and Future Prospects in Herbicide Discovery

Franck E. Dayan

PLANTS-BASEL (2019)

Article Biotechnology & Applied Microbiology

Development of Chromatography Techniques for Analysis and Preparative Isolation of Phytotoxic Metabolites Produced by Stagonospora cirsii

A. O. Berestetskiy et al.

APPLIED BIOCHEMISTRY AND MICROBIOLOGY (2019)

Article Agronomy

A novel genomic approach to herbicide and herbicide mode of action discovery

Stephen O. Duke et al.

PEST MANAGEMENT SCIENCE (2019)

Article Agriculture, Multidisciplinary

Ecological Risk Assessment of Nano-enabled Pesticides: A Perspective on Problem Formulation

Glen W. Walker et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

Review Biochemistry & Molecular Biology

Fungal Phytotoxins in Sustainable Weed Management

Maurizio Vurro et al.

CURRENT MEDICINAL CHEMISTRY (2018)

Article Agronomy

Physicochemical property guidelines for modern agrochemicals

Yu Zhang et al.

PEST MANAGEMENT SCIENCE (2018)

Review Agronomy

Predicting mammalian metabolism and toxicity of pesticides in silico

Robert D. Clark

PEST MANAGEMENT SCIENCE (2018)

Article Biochemistry & Molecular Biology

A new herbicidal site of action: Cinmethylin binds to acyl-ACP thioesterase and inhibits plant fatty acid biosynthesis

Ruth Campe et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2018)

Article Horticulture

Formulation of a bioherbicide with metabolites from Phoma sp.

Izelmar Todero et al.

SCIENTIA HORTICULTURAE (2018)

Article Biochemistry & Molecular Biology

Structure-Based Discovery and Synthesis of Potential Transketolase Inhibitors

Jingqian Huo et al.

MOLECULES (2018)

Article Biochemistry & Molecular Biology

Curvulin and Phaeosphaeride A from Paraphoma sp VIZR 1.46 Isolated from Cirsium arvense as Potential Herbicides

Ekaterina Poluektova et al.

MOLECULES (2018)

Article Agronomy

Weed Management in 2050: Perspectives on the Future of Weed Science

James H. Westwood et al.

WEED SCIENCE (2018)

Article Biochemical Research Methods

In silico target prediction for elucidating the mode of action of herbicides including prospective validation

Rucha K. Chiddarwar et al.

JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2017)

Article Biochemistry & Molecular Biology

Recent advances in tenuazonic acid as a potential herbicide

Shiguo Chen et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2017)

Article Environmental Sciences

Assessment of phenolic herbicide toxicity and mode of action by different assays

Cinzia Bettiol et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2016)

Article Biochemistry & Molecular Biology

The discovery of Arylex™ active and Rinskor™ active: Two novel auxin herbicides

Jeffrey B. Epp et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2016)

Article Agronomy

Suicidal germination for parasitic weed control

Binne Zwanenburg et al.

PEST MANAGEMENT SCIENCE (2016)

Article Biotechnology & Applied Microbiology

Impact of macrocidins, produced by Phoma macrostoma, on carotenoid profiles of plants

M. Hubbard et al.

BIOLOGICAL CONTROL (2015)

Review Biochemistry & Molecular Biology

Fungal phytotoxins with potential herbicidal activity: chemical and biological characterization

Alessio Cimmino et al.

NATURAL PRODUCT REPORTS (2015)

Article Chemistry, Organic

An interactive database to explore herbicide physicochemical properties

Michael N. Gandy et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2015)

Article Engineering, Environmental

Photolysis of natural β-triketonic herbicides in water

Aurelien Trivella et al.

WATER RESEARCH (2015)

Article Plant Sciences

Sarmentine, a natural herbicide from Piper species with multiple herbicide mechanisms of action

Franck E. Dayan et al.

FRONTIERS IN PLANT SCIENCE (2015)

Review Agronomy

Polysaccharides as safer release systems for agrochemicals

Estefania Vangelie Ramos Campos et al.

AGRONOMY FOR SUSTAINABLE DEVELOPMENT (2015)

Review Chemistry, Multidisciplinary

Application of the Intermediate Derivatization Approach in Agrochemical Discovery

Aiying Guan et al.

CHEMICAL REVIEWS (2014)

Review Chemistry, Inorganic & Nuclear

Successful fluorine-containing herbicide agrochemicals

Tomoya Fujiwara et al.

JOURNAL OF FLUORINE CHEMISTRY (2014)

Article Agronomy

Herbicidal activity of formulated sorgoleone, a natural product of sorghum root exudate

Md Romij Uddin et al.

PEST MANAGEMENT SCIENCE (2014)

Article Biotechnology & Applied Microbiology

Major Pesticides Are More Toxic to Human Cells Than Their Declared Active Principles

Robin Mesnage et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Article Biochemistry & Molecular Biology

Mevalocidin: A Novel, Phloem Mobile Phytotoxin from Fusarium DA056446 and Rosellinia DA092917

B. Clifford Gerwick et al.

JOURNAL OF CHEMICAL ECOLOGY (2013)

Review Biochemistry & Molecular Biology

Omics Methods for Probing the Mode of Action of Natural and Synthetic Phytotoxins

Stephen O. Duke et al.

JOURNAL OF CHEMICAL ECOLOGY (2013)

Article Agronomy

Physionomics and metabolomicsutwo key approaches in herbicidal mode of action discovery

Klaus Grossmann et al.

PEST MANAGEMENT SCIENCE (2012)

Review Endocrinology & Metabolism

Metabolomics in pesticide research and development: review and future perspectives

Konstantinos A. Aliferis et al.

METABOLOMICS (2011)

Article Biochemistry & Molecular Biology

Effects of the aglycone of ascaulitoxin on amino acid metabolism in Lemna paucicostata

Stephen O. Duke et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2011)

Review Food Science & Technology

Modes of Action of Microbially-Produced Phytotoxins

Stephen O. Duke et al.

TOXINS (2011)

Article Biotechnology & Applied Microbiology

Albucidin: a novel bleaching herbicide from Streptomyces albus subsp chlorinus NRRL B-24108

Donald R. Hahn et al.

JOURNAL OF ANTIBIOTICS (2009)

Review Agronomy

Natural metabolites for parasitic weed management

Maurizio Vurro et al.

PEST MANAGEMENT SCIENCE (2009)

Article Biochemistry & Molecular Biology

Action mechanism of a novel herbicide, pyroxasulfone

Yoshitaka Tanetani et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2009)

Article Agronomy

Proper adjuvant selection for foramsulfuron activity

JA Bunting et al.

CROP PROTECTION (2004)

Article Biochemistry & Molecular Biology

A novel laboratory screening bioassay for crop seedling allelopathy

RG Belz et al.

JOURNAL OF CHEMICAL ECOLOGY (2004)

Article Agriculture, Multidisciplinary

Herbicidal Properties of the thaxtomin Group of phytotoxins

RR King et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Investigating the mode of action of natural phytotoxins

FE Dayan et al.

JOURNAL OF CHEMICAL ECOLOGY (2000)

Article Agriculture, Multidisciplinary

Search for a standard phytotoxic bioassay for allelochemicals.: Selection of standard target species

FA Macías et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2000)