Journal
CHEMICAL COMMUNICATIONS
Volume 59, Issue 18, Pages 2664-2667Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc06999g
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We present the chemo- and stereoselective electrochemical allylation/alkylation of ethers via C(sp(3))-H activation. This electrosynthetic protocol allows for the synthesis of a diverse library of functionalized ethers (35 examples) in high yields (up to 84%) through cathodic activation of a new type of redox-active carbonate (RAC), which triggers HAT (Hydrogen-Atom-Transfer) events by generating electrophilic oxy radicals. The process demonstrates high functional group tolerance and mild reaction conditions. Mechanistic elucidation through voltammetric analysis completes the study.
The chemo- and stereoselective electrochemical allylation/alkylation of ethers is presented via a C(sp(3))-H activation event. The electrosynthetic protocol enables the realization of a large library of functionalized ethers (35 examples) in high yields (up to 84%) via cathodic activation of a new type of redox-active carbonate (RAC), capable of triggering HAT (Hydrogen-Atom-Transfer) events through the generation of electrophilic oxy radicals. The process displayed high functional group tolerance and mild reaction conditions. A mechanistic elucidation via voltammetric analysis completes the study.
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