Journal
CLINICS IN LABORATORY MEDICINE
Volume 35, Issue 1, Pages 11-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cll.2014.10.007
Keywords
Automated hematology analyzer; Methodology; Leukocyte; White blood cell count; Differential count; Laboratory instrumentation
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Modern hematology laboratories use automated hematology analyzers to perform cell counts. These instruments provide accurate, precise, low-cost differential counts with fast turnaround times. Technologies commonly used include electrical impedance, radiofrequency conductivity, laser light scattering, and cytochemistry. This article reviews the principles of these methodologies and possible sources of error, provides guidance for selecting flagging criteria, and discusses novel, clinically relevant white blood cell parameters provided by new instruments, including immature granulocyte count and granularity index.
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