4.2 Article

The prognostic utility of dynamic risk stratification at disease progression in patients with multiple myeloma

Related references

Note: Only part of the references are listed.
Article Hematology

Outcomes after biochemical or clinical progression in patients with multiple myeloma

Sarah Goldman-Mazur et al.

Summary: It is unclear whether initiating therapy at the time of biochemical progression (BP) improves outcomes compared with initiating therapy at the clinical progression (CP) stage in patients with relapsed MM. This retrospective study found that patients with BP had longer time from second-line treatment to the next treatment and longer overall survival from first relapse. Male sex, plasma cell labeling index >= 2%, and extramedullary disease at diagnosis were associated with higher risk of CP, while very good partial remission or better decreased the risk of CP.

BLOOD ADVANCES (2023)

Article Hematology

How I treat high-risk multiple myeloma

Elena Zamagni et al.

Summary: This article discusses the definitions of high-risk multiple myeloma (MM), trial results, and risk-adapted treatment strategies. For difficult-to-treat patients, therapy should be tailored based on relevant risk factors and biological characteristics.

BLOOD (2022)

Review Oncology

Single-cell profiling of tumour evolution in multiple myeloma - opportunities for precision medicine

Ankit K. Dutta et al.

Summary: This Review discusses the application of single-cell studies in multiple myeloma and its precursor stages, revealing the genetic heterogeneity and clonal evolution patterns. It provides guidance for early diagnosis, risk stratification, and treatment strategies.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

Article Oncology

Oral ixazomib-dexamethasone vs oral pomalidomide-dexamethasone for lenalidomide-refractory, proteasome inhibitor-exposed multiple myeloma: a randomized Phase 2 trial

Meletios A. Dimopoulos et al.

Summary: For multiple myeloma patients, lenalidomide is commonly used as a first-line treatment. However, as patients age, their tolerance to treatment decreases, necessitating alternative options. This study found no significant difference in efficacy between ixazomib-dexamethasone and pomalidomide-dexamethasone, suggesting that ixazomib-dexamethasone can be an important lenalidomide-free oral option for heavily pretreated, lenalidomide-refractory patients exposed to proteasome inhibitors.

BLOOD CANCER JOURNAL (2022)

Article Oncology

A simple additive staging system for newly diagnosed multiple myeloma

Nadine H. Abdallah et al.

Summary: Risk stratification is crucial in multiple myeloma for predicting prognosis, selecting patients for clinical trials, and comparing treatment approaches. A new staging system has been developed that incorporates additional high-risk disease features and improves upon the current risk stratification system. This system is easy to implement and provides valuable prognostic information.

BLOOD CANCER JOURNAL (2022)

Article Hematology

Clonal phylogeny and evolution of critical cytogenetic aberrations in multiple myeloma at single-cell level by QM-FISH

Yuting Yan et al.

Summary: Single-cell analysis is crucial for understanding the evolutionary process of subclonal populations in multiple myeloma (MM). This study found that patients with clonal stabilization had significantly improved overall survival. The results of quantitative multigene fluorescence in situ hybridization (QM-FISH) and conventional FISH (cFISH) were highly consistent and complementary in evaluating cytogenetic evolution patterns. Evaluating high-risk aberrations had a greater impact on survival after relapse.

BLOOD ADVANCES (2022)

Article Hematology

Prognostic value of minimal residual disease negativity in myeloma: combined analysis of POLLUX, CASTOR, ALCYONE, and MAIA

Michele Cavo et al.

Summary: In this study, we explored the impact of minimal residual disease (MRD) on relapsed/refractory multiple myeloma (RRMM) and transplant-ineligible newly diagnosed multiple myeloma (TIE NDMM). The results showed that achieving complete response or better (>= CR) and MRD negativity were associated with improved progression-free survival (PFS) in both RRMM and TIE NDMM patients, regardless of the type of therapy or disease setting.

BLOOD (2022)

Article Oncology

Minimal Residual Disease After Autologous Stem-Cell Transplant for Patients With Myeloma: Prognostic Significance and the Impact of Lenalidomide Maintenance and Molecular Risk

Ruth M. de Tute et al.

Summary: This study found that MRD status at ASCT + 3 and ASCT + 9 is a powerful predictor of PFS and OS in patients with multiple myeloma. Lenalidomide maintenance therapy can increase the likelihood of converting from MRD-positive to MRD-negative. However, high-risk molecular features still have a negative impact on PFS and OS.

JOURNAL OF CLINICAL ONCOLOGY (2022)

Article Oncology

Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project

Mattia D'Agostino et al.

Summary: In this study, the Revised International Staging system (R-ISS) for intermediate-risk multiple myeloma patients was revised based on the additive value of each single risk feature.

JOURNAL OF CLINICAL ONCOLOGY (2022)

Article Oncology

Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence

Kristine Misund et al.

Summary: We investigated the genomic and transcriptomic changes in multiple myeloma patients before and after treatment. The study discovered changes in clonal composition and increased single-nucleotide variants. It also found alterations in specific genes and pathways, such as RAS genes, amp1q21, and TP53, and identified increased expression of potentially targetable genes in late-stage disease.

LEUKEMIA (2022)

Article Hematology

Early relapse after high-dose melphalan autologous stem cell transplant predicts inferior survival and is associated with high disease burden and genetically high-risk disease in multiple myeloma

Ceri Bygrave et al.

Summary: Despite equal access to subsequent therapies, myeloma patients who relapse early within 12 months of autologous stem cell transplant have significantly worse progression-free survival and overall survival compared to later relapsing patients, highlighting the urgent need for improved outcome prediction and early intervention strategies.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

Article Oncology

Copy number evolution and its relationship with patient outcome-an analysis of 178 matched presentation-relapse tumor pairs from the Myeloma XI trial

James Croft et al.

Summary: Structural chromosomal changes, including CNAs, differ between MM subtypes. Acquired del(17p) in CCND2 tumors and a branching evolutionary pattern are associated with inferior OS. Acquisition of gain(1q) at relapse is linked to shorter OS, independent of other risk markers.

LEUKEMIA (2021)

Review Hematology

Improving outcomes for patients with relapsed multiple myeloma: Challenges and considerations of current and emerging treatment options

Karthik Ramasamy et al.

Summary: Despite the introduction of new therapies, multiple myeloma remains incurable and the treatment landscape is becoming increasingly complex. Relapsed refractory multiple myeloma presents a significant clinical challenge, with a highly heterogeneous patient population requiring careful consideration for treatment selection. Multiple treatment options are continually growing, with emerging novel therapies under clinical development.

BLOOD REVIEWS (2021)

Review Hematology

Current approaches to management of high-risk multiple myeloma

Sarah Goldman-Mazur et al.

Summary: The median overall survival for multiple myeloma patients is nearly 10 years, but a significant percentage still have poor prognosis. Therefore, individualized and intensive treatment approaches should be utilized, especially for high-risk patients. This includes using effective drug combinations, considering autologous stem cell transplantation, and maintenance based on proteasome inhibitor-based combinations.

AMERICAN JOURNAL OF HEMATOLOGY (2021)

Article Hematology

Progression signature underlies clonal evolution and dissemination of multiple myeloma

Yu Jia Shen et al.

Summary: Clonal evolution plays a key role in tumor progression, dissemination, and relapse in multiple myeloma (MM). By developing a clone-tracking system, researchers studied clonal behavior in the bone marrow microenvironment, identifying specific clones able to adapt and colonize distant sites. RNA sequencing revealed a progression signature in MM tumor cells, leading to the prediction of 28 master regulators, with HMGA1 and PA2G4 validated as key players in MM progression and dissemination, impacting cell functions like proliferation, migration, and adhesion. This study successfully replicates key characteristics of human MM disease progression and suggests potential therapeutic targets.

BLOOD (2021)

Article Hematology

CAR T-cell therapy for multiple myeloma: state of the art and prospects

Niels W C J van de Donk et al.

Lancet Haematology (2021)

Article Oncology

Post-Progression Survival Influences Overall Survival among Patients with Advanced Non-Small Cell Lung Cancer Undergoing First-Line Pembrolizumab Monotherapy

Hisao Imai et al.

Summary: Among NSCLC patients with high PD-L1 expression undergoing first-line pembrolizumab monotherapy, post-progression survival (PPS) was found to be more strongly correlated with overall survival (OS) compared to progression-free survival (PFS). This suggests that subsequent treatment significantly influences OS in patients with disease progression following first-line pembrolizumab monotherapy.

ONCOLOGY (2021)

Article Hematology

Progression with clinical features is associated with worse subsequent survival in multiple myeloma

Rajshekhar Chakraborty et al.

AMERICAN JOURNAL OF HEMATOLOGY (2019)

Review Hematology

CD38 antibodies in multiple myeloma: back to the future

Niels W. C. J. van de Donk et al.

BLOOD (2018)

Review Oncology

Clinical significance of post-progression survival in lung cancer

Hisao Imai et al.

THORACIC CANCER (2017)

Article Biophysics

Impact of early relapse after auto-SCT for multiple myeloma

S. Kumar et al.

BONE MARROW TRANSPLANTATION (2008)

Article Oncology

International staging system for multiple myeloma

PR Greipp et al.

JOURNAL OF CLINICAL ONCOLOGY (2005)