Journal
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
Volume 14, Issue 1, Pages -Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/20008066.2023.2178762
Keywords
Resilience; genetics; alcohol; PTSD
Categories
Ask authors/readers for more resources
Although trauma exposure is a risk factor for psychiatric disorders, not everyone develops a disorder, which may be due to resilience. This study aimed to examine the genetic underpinnings of psychiatric resilience using GWAS, GCTA, and PRS analyses. The results suggest the need for further research to understand the etiology of resilience and its overlap with certain disorders.
Background: Although trauma exposure (TE) is a transdiagnostic risk factor for many psychiatric disorders, not everyone who experiences TE develops a psychiatric disorder. Resilience may explain this heterogeneity; thus, it is critical to understand the etiologic underpinnings of resilience. Objective: The present study sought to examine the genetic underpinnings of psychiatric resilience using genome-wide association studies (GWAS), genome-wide complex trait analysis (GCTA), and polygenic risk score (PRS) analyses. Method: Participants were 6,634 trauma exposed college students attending a diverse, public university in the Mid Atlantic. GWAS and GCTA analyses were conducted, and using GWAS summary statistics from large genetic consortia, PRS analyses examined the shared genetic risk between resilience and various phenotypes. Results: Results demonstrate that nine single-nucleotide polymorphisms (SNPs) met the suggestive of significance threshold, heritability estimates for resilience were non-significant, and that there is genetic overlap between resilience and AD, as well as resilience and PTSD. Conclusion: Mixed findings from the present study suggest additional research to elucidate the etiological underpinnings of resilience, ideally with larger samples less biased by variables such as heterogeneity (i.e. clinical vs. population based) and population stratification. Genetic investigations of resilience have the potential to elucidate the molecular bases of stress-related psychopathology, suggesting new avenues for prevention and intervention efforts.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available