Journal
CLINICAL & TRANSLATIONAL ONCOLOGY
Volume 25, Issue 7, Pages 2043-2055Publisher
SPRINGER INT PUBL AG
DOI: 10.1007/s12094-023-03117-5
Keywords
Nanoparticles; Therapy; Influencing factors; Evaluation methods; Biosafety
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Nanoparticles are widely used in the biomedical field for their small size, high carrier capacity, and ease of modification. However, their unique physicochemical properties and interactions with biological components create a high potential for unpredictable adverse effects on human organs, tissues, and cells. It is essential to evaluate the safety of nanoparticles in living organisms by considering their properties and utilizing common methods for biosafety evaluation.
Nanoparticles are widely used in the biomedical field for diagnostic and therapeutic purposes due to their small size, high carrier capacity, and ease of modification, which enable selective targeting and as contrast agents. Over the past decades, more and more nanoparticles have received regulatory approval to enter the clinic, more nanoparticles have shown potential for clinical translation, and humans have increasing access to them. However, nanoparticles have a high potential to cause unpredictable adverse effects on human organs, tissues, and cells due to their unique physicochemical properties and interactions with DNA, lipids, cells, tissues, proteins, and biological fluids. Currently, issues, such as nanoparticle side effects and toxicity, remain controversial, and these pitfalls must be fully considered prior to their application to body systems. Therefore, it is particularly urgent and important to assess the safety of nanoparticles acting in living organisms. In this paper, we review the important factors influencing the biosafety of nanoparticles in terms of their properties, and introduce common methods to summarize the biosafety evaluation of nanoparticles through in vitro and in body systems.
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