Journal
GREEN CHEMISTRY
Volume 25, Issue 6, Pages 2279-2286Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2gc04506k
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Since the development of palladium-catalyzed cyanation in 1973, there has been widespread interest in the transition metal-catalyzed cyanation of aryl halides using Pd, Ni, and Cu. However, these reactions require highly polar organic solvents and high temperatures. In this study, we have developed a non-toxic K-4[Fe(CN)(6)]-promoted mechanochemical palladium-catalyzed solid-state cyanation of aryl bromides using an electromagnetic mill (EMM) without additional heating. This strategy offers a broad substrate scope, good functional group tolerance, liquid-assisted grinding, air and moisture insensitivity, no additional heating requirement, and efficient gram-scale synthesis.
Since Takagi et al. first developed palladium-catalyzed cyanation in 1973, transition metal-catalyzed cyanation of aryl halides, using Pd, Ni and Cu, has attracted widespread interest. However, the reactions are all dependent on highly polar organic solvents and high temperatures. Herein, we have developed the first electromagnetic mill (EMM) promoted mechanochemical palladium-catalyzed solid state cyanation of aryl bromides using non-toxic K-4[Fe(CN)(6)] without additional heating. This strategy features broad substrate scope, good functional group tolerance, liquid-assisted grinding, air and moisture insensitivity, no additional heating, and efficient gram-scale synthesis. The EMM conditions can improve the efficiency of the reaction by colliding better mixed solid reactants with ferromagnetic rods at high speed. This EMM system not only provides a simple method for the preparation of aromatic nitriles which have a wide industrial application prospect, but also affords a broad space for liquid-assisted grinding solid metal catalytic synthesis.
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