Journal
ANALYTICAL CHEMISTRY
Volume 95, Issue 5, Pages 2884-2892Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.2c044192884Anal
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A simple enzyme-free colorimetric method is developed for quick detection of PIK3CA gene mutations, utilizing the distinct interactions between praseodymia nanorods and different nucleotides, as well as the oxidase-mimicking characteristics of praseodymia. This method has potential for expanded applications in screening mutations in other genes of interest.
The frequently mutated phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) gene is associated with multiple tumors and endocytosis of viruses. Identification of muted nucleotides at the hotspot can help in finding the susceptible people who are vulnerable to cancers and viruses. Herein, a simple enzyme-free colorimetric method is developed for the quick detection of PIK3CA gene mutations. The main mechanism lies in the dissimilar interactions between praseodymia nanorods and different nucleotides, as well as the underlying oxidase-mimicking characteristics of praseodymia. With rational designs of probes and processes, this method has great potential for expanded applications in the screening of mutations in other genes of interest.
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