Synthetic benzofuran-linked chalcones with dual actions: a potential therapeutic approach to manage diabetes mellitus

Background: Identification of molecules having dual capabilities to reduce postprandial hyperglycemia and oxidative stress is one of the therapeutic approaches to treat diabetes mellitus. In this connection, a library of benzofuran-linked chalcone derivatives were evaluated for their dual action. Methods: A series of substituted benzofuran-linked chalcones (2-33) were synthesized and tested for alpha-amylase inhibitory as well as 2,2-diphenylpicrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activities. Results: All compounds showed alpha-amylase inhibitory activity ranging from IC50 = 12.81 +/- 0.03 to 87.17 +/- 0.15 mu M, compared with the standard acarbose (IC50 = 13.98 +/- 0.03 mu M). Compounds also demonstrated radical scavenging potential against DPPH and ABTS radicals. Conclusion: The identified compounds may serve as potential leads for further advanced research. [GRAPHICS]

Automated summary

In this study, benzofuran-linked chalcone derivatives were evaluated for their dual action in reducing postprandial hyperglycemia and oxidative stress, showing potential as a therapeutic approach for diabetes mellitus.