Journal
AMERICAN JOURNAL OF MENS HEALTH
Volume 17, Issue 1, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/15579883231153018
Keywords
metabolomics; weight loss; cancer prevention < oncology; cancer; Mexican-origin Hispanic; birthplace
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This study aimed to investigate the differences in metabolomic profiles between foreign and U.S-born Mexican-origin Hispanic men and shed light on the mechanisms through which birthplace influences cancer risk and risk factors. The results showed that the plasma metabolomic profiles of MO Hispanic men differed based on their birthplace. These findings improve our understanding of the relevant exposures that may impact cancer risk among MO Hispanic men.
Birthplace, as a proxy for environmental exposures (e.g., diet), may influence metabolomic profiles and influence risk of cancer. This secondary analysis investigated metabolomic profile differences between foreign and U.S.-born Mexican-origin (MO) Hispanic men to shed light on potential mechanisms through which foreign- and U.S.-born individuals experience differences in cancer risk and risk factors. Plasma samples from MO Hispanic men (N = 42) who participated in a previous lifestyle intervention were collected pre-and post-intervention. Metabolomic profiles were characterized from samples using ultra performance liquid chromatography-quadrupole time of flight mass spectrometry (UPLC-QTOF). Models were visualized using supervised orthogonal projections to latent structures-discriminant analysis (OPLS-DA). Progenesis QI was used for peak integration and metabolite identification. Plasma metabolomic profiles differed between foreign- and U.S.-born pre-intervention (R2 = .65) and post-intervention (R2 = .62). Metabolomic profiles differed pre- versus post-intervention (R2 = .35 and R2 = .65) for the foreign- and U.S.-born group, respectively. Both endogenous metabolites and dietary components characterized differences between foreign- and U.S.-born participants pre- and post-intervention. Plasma metabolomic profiles from MO Hispanic men differed by birthplace. These results advance our understanding of relevant exposures that may affect cancer risk among MO Hispanic men born abroad or in the United States.
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