3.8 Article

Anti-G protein antibodies targeting the RSV G protein CX3C chemokine region improve the interferon response

Related references

Note: Only part of the references are listed.
Article Virology

Probenecid Inhibits Respiratory Syncytial Virus (RSV) Replication

Jackelyn Murray et al.

Summary: This study investigated the prophylactic and therapeutic efficacy of probenecid, an FDA-approved drug, in inhibiting RSV replication. The results showed that nanomolar concentrations of probenecid prevented RSV replication in vitro and in vivo, suggesting its potential as a prophylactic and chemotherapeutic agent for RSV.

VIRUSES-BASEL (2022)

Review Medicine, General & Internal

Bronchiolitis

Stuart R. Dalziel et al.

Summary: Viral bronchiolitis is the leading cause of infant hospitalization in high-income countries. Clinical diagnosis is sufficient and viral testing is not necessary. The recommended management is supportive, focusing on hydration and oxygenation, while glucocorticoids and bronchodilators are not recommended. However, there is a lack of sufficient evidence for the treatment of bronchiolitis.

LANCET (2022)

Article Immunology

Type III Interferons, Viral Loads, Age, and Disease Severity in Young Children With Respiratory Syncytial Virus Infection

Jeanette Taveras et al.

Summary: In this study, children with milder RSV infection and those aged >6 months had higher concentrations of mucosal interferons, which may be associated with protection against severe RSV disease. Higher levels of IL6 increased the likelihood of hospitalization in older children, while higher concentrations of IFN-lambda 2/3 had the opposite effect regardless of age. Additionally, higher concentrations of CXCL10 were associated with reduced odds of hospitalization, oxygen administration, PICU admission, and prolonged hospitalization.

JOURNAL OF INFECTIOUS DISEASES (2022)

Review Virology

RSV Replication, Transmission, and Disease Are Influenced by the RSV G Protein

Harrison C. Bergeron et al.

Summary: Understanding the features affecting virus replication, fitness, and transmissibility is crucial for the prevention and treatment of respiratory syncytial virus (RSV) infection. However, our current knowledge of RSV replication, immunity, and disease is incomplete. This review focuses on the impact of the RSV G protein on viral features and highlights the importance of studying the role of G protein in preclinical research.

VIRUSES-BASEL (2022)

Article Virology

Respiratory Syncytial Virus (RSV) G Protein Vaccines With Central Conserved Domain Mutations Induce CX3C-CX3CR1 Blocking Antibodies

Harrison C. Bergeron et al.

Summary: This study showed that the G protein immunogens induced a significant anti-G protein antibody response, and the antibodies produced were capable of blocking the binding of RSV G protein CX3C-CX3CR1. These antibodies did not interfere with CX3CL1, fractalkine.

VIRUSES-BASEL (2021)

Review Virology

Immunopathology of RSV: An Updated Review

Harrison C. Bergeron et al.

Summary: RSV is a major cause of respiratory tract disease in infants and the elderly, with limited therapeutic interventions and no FDA-approved vaccine. This review provides an update on the current understanding of RSV immunity and immunopathology, focusing on interferon responses, animal modeling, and correlates of protection.

VIRUSES-BASEL (2021)

Article Immunology

High Dose IFN-β Activates GAF to Enhance Expression of ISGF3 Target Genes in MLE12 Epithelial Cells

Kensei Kishimoto et al.

Summary: IFN-beta signaling can activate both ISGF3 and GAF in murine lung epithelial cells, with GAF potentially acting as a dose-sensitive amplifier of ISG expression to enhance antiviral immunity.

FRONTIERS IN IMMUNOLOGY (2021)

Article Virology

CX3CR1 Is a Receptor for Human Respiratory Syncytial Virus in Cotton Rats

Gia Green et al.

Summary: This study demonstrates that CX3CR1 acts as a receptor for RSV in cotton rats, similar to its role in human airway epithelial cell cultures, suggesting that CX3CR1 is a primary receptor for naturally acquired RSV infection.

JOURNAL OF VIROLOGY (2021)

Review Virology

Functional Features of the Respiratory Syncytial Virus G Protein

Larry J. Anderson et al.

Summary: Respiratory syncytial virus (RSV) causes serious respiratory infections in young children and the elderly. The G protein, alongside the F protein, is a key target for vaccine and antiviral drug development due to its role in cellular infection and modulation of immune responses.

VIRUSES-BASEL (2021)

Review Pharmacology & Pharmacy

Emerging small and large molecule therapeutics for respiratory syncytial virus

Harrison C. Bergeron et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2020)

Review Biotechnology & Applied Microbiology

Up-to-date role of biologics in the management of respiratory syncytial virus

Seyhan Boyoglu-Barnum et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2020)

Review Immunology

Respiratory Syncytial Virus's Non-structural Proteins: Masters of Interference

Elena Margaret Thornhill et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Article Medicine, Research & Experimental

Efficacy and safety of interferon on neonates with respiratory syncytial virus pneumonia

Lingyun He et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

Review Immunology

Shared and Distinct Functions of Type I and Type III Interferons

Helen M. Lazear et al.

IMMUNITY (2019)

Review Microbiology

Current Animal Models for Understanding the Pathology Caused by the Respiratory Syncytial Virus

Maria Jose Altamirano-Lagos et al.

FRONTIERS IN MICROBIOLOGY (2019)

Review Microbiology

Decoding type I and III interferon signalling during viral infection

Emily Mesev et al.

NATURE MICROBIOLOGY (2019)

Review Microbiology

ISG15 in antiviral immunity and beyond

Yi-Chieh Perng et al.

NATURE REVIEWS MICROBIOLOGY (2018)

Article Immunology

Structures of respiratory syncytial virus G antigen bound to broadly neutralizing antibodies

Stanislav O. Fedechkin et al.

SCIENCE IMMUNOLOGY (2018)

Article Critical Care Medicine

Palivizumab Prophylaxis in Preterm Infants and Subsequent Recurrent Wheezing Six-Year Follow-up Study

Hiroyuki Mochizuki et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

Review Microbiology

The Human Immune Response to Respiratory Syncytial Virus Infection

Clark D. Russell et al.

CLINICAL MICROBIOLOGY REVIEWS (2017)

Review Oncology

Respiratory syncytial virus (RSV) and its propensity for causing bronchiolitis

Raymond J. Pickles et al.

JOURNAL OF PATHOLOGY (2015)

Review Immunology

Type I interferons in infectious disease

Finlay McNab et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Article Infectious Diseases

Interferon lambda 1-3 expression in infants hospitalized for RSV or HRV associated bronchiolitis

Carla Selvaggi et al.

JOURNAL OF INFECTION (2014)

Review Immunology

Regulation of type I interferon responses

Lionel B. Ivashkiv et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Review Biochemistry & Molecular Biology

Suppression of cytokine signaling: The SOCS perspective

Edmond M. Linossi et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2013)

Review Immunology

Therapeutic targeting of respiratory syncytial virus G-protein

Lawrence M. Kauvar et al.

IMMUNOTHERAPY (2010)

Article Biotechnology & Applied Microbiology

Palivizumab: where to from here?

Georgiana Georgescu et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2009)

Review Biochemistry & Molecular Biology

Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history

Patricia Fitzgerald-Bocarsly et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2008)

Article Biochemistry & Molecular Biology

Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma

Michishige Harada et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2007)

Article Multidisciplinary Sciences

The cysteine-rich region of respiratory syncytial virus attachment protein inhibits innate immunity elicited by the virus and endotoxin

FP Polack et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Immunology

Mechanisms of type-I- and type-II-interferon-mediated signalling

LC Platanias

NATURE REVIEWS IMMUNOLOGY (2005)

Review Immunology

Suppressors of cytokine signalling (SOCS) in the immune system

WS Alexander

NATURE REVIEWS IMMUNOLOGY (2002)

Article Immunology

CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein

RA Tripp et al.

NATURE IMMUNOLOGY (2001)