3.9 Review

APE2: catalytic function and synthetic lethality draw attention as a cancer therapy target

Related references

Note: Only part of the references are listed.
Article Cell Biology

HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation

Lizhen Wu et al.

Summary: The DNA repair factor HMCES can strongly suppress deletions, facilitating the production of antigen-specific antibodies. Their findings propose a novel model for protecting Ig gene integrity during SHM.

GENES & DEVELOPMENT (2022)

Article Multidisciplinary Sciences

TDP1-independent pathways in the process and repair of TOP1-induced DNA damage

Huimin Zhang et al.

Summary: The authors found that MUS81 plays a role in mediating excess DNA double-strand break (DSB) generation in TDP1 KO cells after camptothecin treatment. They demonstrate that TOP1 cleavage complexes can either be directly resolved by TDP1 or be converted into DSBs and repaired by the Homologous Recombination pathway.

NATURE COMMUNICATIONS (2022)

Review Oncology

Anti-cancer immune responses to DNA damage response inhibitors: Molecular mechanisms and progress toward clinical translation

Lindsey Carlsen et al.

Summary: DNA damage response inhibitors are effective anti-cancer agents that sensitize tumor cells to radiotherapy and chemotherapy while also stimulating immune responses. However, the contribution of different inhibitors and genetic aberrations in cancers to immune mechanisms is not well-characterized, limiting the optimization of treatment regimens.

FRONTIERS IN ONCOLOGY (2022)

Article Biochemistry & Molecular Biology

Apurinic/Apyrimidinic Endonuclease 2 (APE2): An ancillary enzyme for contextual base excision repair mechanisms to preserve genome stability

Sima Chaudhari et al.

Summary: APE2 is a multifunctional repair protein essential for maintaining genome stability, with independent and non-redundant functions compared to other repair pathways. It plays a crucial role in DNA damage response and various functional pathways related to genome integrity.

BIOCHIMIE (2021)

Article Oncology

Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney Injury

Yi Hu et al.

Summary: This study identified APE2 as a critical molecule upregulated in the kidney following cisplatin treatment, leading to MYH9 dysfunction in mitochondria and potential development of AKI. Knockout of APE2 attenuated cisplatin-induced kidney injury, suggesting a novel target for prophylactic treatment of AKI.

CANCER RESEARCH (2021)

Article Oncology

Celastrol in cancer therapy: Recent developments, challenges and prospects

Hannah Ying Lim et al.

Summary: The review summarizes the potential and mechanisms of celastrol in cancer treatment, discusses the obstacles hindering its use in humans, and provides insights into future directions for research and development.

CANCER LETTERS (2021)

Review Biotechnology & Applied Microbiology

Function and molecular mechanisms of APE2 in genome and epigenome integrity

Yunfeng Lin et al.

Summary: APE2 is recognized as an essential player in maintaining the integrity of the genome and epigenome. This review provides a comprehensive overview of APE2, including its functional domains, nuclease activities, interaction proteins, roles in various DNA repair pathways, and functions in growth, development, and diseases.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2021)

Article Cell Biology

APE2 Is a General Regulator of the ATR-Chk1 DNA Damage Response Pathway to Maintain Genome Integrity in Pancreatic Cancer Cells

Md Akram Hossain et al.

Summary: APE2 is essential for activating the ATR DDR pathway in response to various stressful conditions in Xenopus laevis egg extracts and human pancreatic cancer cells. Inhibition of APE2 leads to increased DNA damage and sensitizes cancer cells to chemotherapy drugs, indicating its crucial role in maintaining genome integrity.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand

Parasvi S. Patel et al.

Summary: The principle of synthetic lethality, aiming at disrupting two genes to eliminate tumors, particularly in BRCA1/2-mutated cancers, has been a focus in cancer research. Although PARP inhibitors have shown clinical success in certain cases, resistance remains an issue and the exploration of alternative targets is crucial for future therapies. Various synthetic lethal interactors of BRCA1/2 have been identified, providing potential avenues for the development of new targeted therapies.

ONCOGENE (2021)

Article Oncology

A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors

Jia Zhou et al.

Summary: The antibiotic novobiocin has been identified as a specific POLQ inhibitor with preclinical activity in homologous-recombination-deficient breast and ovarian tumors, including those with acquired PARP inhibitor resistance. This study suggests that novobiocin may be useful alone or in combination with PARP inhibitors for treating HR-deficient tumors.

NATURE CANCER (2021)

Article Biochemistry & Molecular Biology

APE1 senses DNA single-strand breaks for repair and signaling

Yunfeng Lin et al.

NUCLEIC ACIDS RESEARCH (2020)

Article Multidisciplinary Sciences

Genomic alterations and abnormal expression of APE2 in multiple cancers

Katherine A. Jensen et al.

SCIENTIFIC REPORTS (2020)

Article Multidisciplinary Sciences

Mechanistic basis for microhomology identification and genome scarring by polymerase theta

Juan Carvajal-Garcia et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Medicine, General & Internal

Identification of APEX2 as an oncogene in liver cancer

Ru Zheng et al.

WORLD JOURNAL OF CLINICAL CASES (2020)

Review Biochemistry & Molecular Biology

PARP inhibitor resistance: the underlying mechanisms and clinical implications

He Li et al.

MOLECULAR CANCER (2020)

Article Biochemistry & Molecular Biology

Endogenous DNA 3′ Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease

Alejandro Alvarez-Quilon et al.

MOLECULAR CELL (2020)

Article Biochemistry & Molecular Biology

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo

Zhengping Shao et al.

NUCLEIC ACIDS RESEARCH (2020)

Article Biochemistry & Molecular Biology

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets

Kristen E. Mengwasser et al.

MOLECULAR CELL (2019)

Article Biochemistry & Molecular Biology

Apn2 resolves blocked 3′ ends and suppresses Top1-induced mutagenesis at genomic rNMP sites

Fuyang Li et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)

Editorial Material Biochemistry & Molecular Biology

Resolution of a complex crisis at DNA 3′ termini

Shan Yan

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)

Review Genetics & Heredity

Templated Insertions: A Smoking Gun for Polymerase Theta-Mediated End Joining

Joost Schimmel et al.

TRENDS IN GENETICS (2019)

Article Biochemistry & Molecular Biology

A consensus set of genetic vulnerabilities to ATR inhibition

Nicole Hustedt et al.

OPEN BIOLOGY (2019)

Article Biochemistry & Molecular Biology

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

Vyacheslav Akimov et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

APE2 promotes DNA damage response pathway from a single-strand break

Yunfeng Lin et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells

Dongsung Kim et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Multidisciplinary Sciences

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

Stephen J. Pettitt et al.

NATURE COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

Vyacheslav Akimov et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2

Md. Akram Hossain et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Multidisciplinary Sciences

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

Michal Zimmermann et al.

NATURE (2018)

Review Oncology

Targeting ATR in cancer

Emilio Lecona et al.

NATURE REVIEWS CANCER (2018)

Article Multidisciplinary Sciences

APE2 Zf-GRF facilitates 3′-5′ resection of DNA damage following oxidative stress

Bret D. Wallace et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Biochemistry & Molecular Biology

Genomic rearrangements induced by unscheduled DNA double strand breaks in somatic mammalian cells

Ayeong So et al.

FEBS JOURNAL (2017)

Review Biochemistry & Molecular Biology

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

Andrew N. Blackford et al.

MOLECULAR CELL (2017)

Review Multidisciplinary Sciences

PARP inhibitors: Synthetic lethality in the clinic

Christopher J. Lord et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

Site-specific identification and quantitation of endogenous SUMO modifications under native conditions

Ryan J. Lumpkin et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Mutational signatures of non-homologous and polymerase theta-mediated end-joining in embryonic stem cells

Joost Schimmel et al.

EMBO JOURNAL (2017)

Review Medicine, General & Internal

Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases

Rita Cascao et al.

FRONTIERS IN MEDICINE (2017)

Review Developmental Biology

Cell-free Xenopus egg extracts for studying DNA damage response pathways

Steven Cupello et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability

Huzefa Dungrawala et al.

MOLECULAR CELL (2015)

Review Biochemistry & Molecular Biology

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

Shan Yan et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2014)

Article Genetics & Heredity

DNA double-strand break repair pathway choice and cancer

Tomas Aparicio et al.

DNA REPAIR (2014)

Review Oncology

Replication stress and cancer: It takes two to tango

Emilio Lecona et al.

EXPERIMENTAL CELL RESEARCH (2014)

Article Oncology

Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib

Junko Murai et al.

MOLECULAR CANCER THERAPEUTICS (2014)

Article Multidisciplinary Sciences

Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation

Janet Stavnezer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Biotechnology & Applied Microbiology

Pathophysiology of Cisplatin-Induced Acute Kidney Injury

Abdullah Ozkok et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Review Cell Biology

Regulation of AID, the B-cell genome mutator

Celia Keim et al.

GENES & DEVELOPMENT (2013)

Article Biochemistry & Molecular Biology

Topoisomerase 1-Mediated Removal of Ribonucleotides from Nascent Leading-Strand DNA

Jessica S. Williams et al.

MOLECULAR CELL (2013)

Article Multidisciplinary Sciences

Uracil in duplex DNA is a substrate for the nucleotide incision repair pathway in human cells

Paulina Prorok et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress

Jeremy Willis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Oncology

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

Junko Murai et al.

CANCER RESEARCH (2012)

Article Multidisciplinary Sciences

Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

Nayun Kim et al.

SCIENCE (2011)

Review Biochemistry & Molecular Biology

Oxidative stress, inflammation, and cancer How are they linked?

Simone Reuter et al.

FREE RADICAL BIOLOGY AND MEDICINE (2010)

Review Biochemistry & Molecular Biology

The DNA Damage Response: Making It Safe to Play with Knives

Alberto Ciccia et al.

MOLECULAR CELL (2010)

Article Biochemistry & Molecular Biology

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

Bunsyo Shiotani et al.

MOLECULAR CELL (2009)

Article Biology

The roles of APE1, APE2, DNA polymerase β and mismatch repair in creating S region DNA breaks during antibody class switch

Carol E. Schrader et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2009)

Review Immunology

Mechanism and regulation of class switch recombination

Janet Stavnezer et al.

ANNUAL REVIEW OF IMMUNOLOGY (2008)

Article Oncology

A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

Tao Zhang et al.

MOLECULAR CANCER THERAPEUTICS (2008)

Review Cell Biology

ATR: an essential regulator of genome integrity

Karlene A. Cimprich et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Review Cell Biology

Regulation of DNA double-strand break repair pathway choice

Meena Shrivastav et al.

CELL RESEARCH (2008)

Article Immunology

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination

Jeroen E. J. Guikema et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

Article Multidisciplinary Sciences

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Shuhei Matsuoka et al.

SCIENCE (2007)

Article Biochemistry & Molecular Biology

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

Minli Wang et al.

NUCLEIC ACIDS RESEARCH (2006)

Article Biochemistry & Molecular Biology

Human Ape2 protein has a 3 '-5 ' exonuclease activity that acts preferentially on mismatched base pairs

Peter Burkovics et al.

NUCLEIC ACIDS RESEARCH (2006)

Article Biochemistry & Molecular Biology

Modulation of DNA end joining by nuclear proteins

L Liang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biotechnology & Applied Microbiology

Characterization of the genomic structure and expression of the mouse Apex2 gene

Y Ide et al.

GENOMICS (2003)