3.8 Article

Clinical Validation of the sFlt-1:PlGF Ratio as a Biomarker for Preeclampsia Diagnosis in a High-Risk Obstetrics Unit

Related references

Note: Only part of the references are listed.
Review Obstetrics & Gynecology

Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia

Anne Cathrine Staff et al.

Summary: Physiological transformation and remodeling of uteroplacental spiral arteries play a key role in successful placentation and normal placental function. Poor remodeling is associated with early-onset preeclampsia and other major obstetrical syndromes. Acute atherosis, a foam cell lesion, is linked to poor remodeling and may be triggered by inflammatory stimulation. Understanding this uteroplacental interface is crucial for understanding the pathophysiology of preeclampsia and its short- and long-term effects on pregnancy.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2022)

Review Medicine, General & Internal

Clinical tools and biomarkers to predict preeclampsia

Teresa M. MacDonald et al.

Summary: Preeclampsia is a pregnancy-specific disease that has a significant impact on maternal and perinatal morbidity and mortality worldwide. Currently, there are limited options for predicting and diagnosing preeclampsia, and further research is needed to identify effective tests and biomarkers.

EBIOMEDICINE (2022)

Article Medical Laboratory Technology

Analytical Performance and Quality Indicators of Fully Automated Immunoassays for sFlt-1 and PIGF

Victoria Higgins et al.

Summary: This study evaluated the analytical performance and quality indicators of the Elecsys sFlt-1 and PIGF assays at the first North American site to implement them clinically. Results showed low short-term and long-term imprecision, accurate method comparison, and compliance with repeat test frequency and turnaround time requirements.

JOURNAL OF APPLIED LABORATORY MEDICINE (2022)

Article Peripheral Vascular Disease

Prediction of Preeclampsia-Related Adverse Outcomes With the sFlt-1 (Soluble fms-Like Tyrosine Kinase 1)/PlGF (Placental Growth Factor)-Ratio in the Clinical Routine A Real-World Study

Lisa Antonia Droge et al.

Summary: This retrospective real-world study investigated the clinical utility of sFlt-1/PlGF ratio in predicting adverse outcomes in patients with signs and symptoms of preeclampsia. The study found that patients classified as high or intermediate risk based on the ratio were more likely to have adverse outcomes, and combining biomarker measurements with all available clinical information improved detection of adverse outcomes in women with suspected disease.

HYPERTENSION (2021)

Article Obstetrics & Gynecology

Enhancing the value of the sFlt-1/PlGF ratio for the prediction of preeclampsia: Cost analysis from the Belgian healthcare payers' perspective

Frederic Chantraine et al.

Summary: The study evaluated the economic impact of introducing the sFlt-1/PlGF ratio test in clinical practice in Belgium for predicting preeclampsia, finding that the test can result in cost savings of approximately 712 euros per patient mainly due to a reduction in unnecessary hospitalizations. This represents a significant cost saving for the Belgian public healthcare payers.

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH (2021)

Review Medicine, General & Internal

Pre-eclampsia

Lucy C. Chappell et al.

Summary: Pre-eclampsia is a pregnancy disorder characterized by placental malperfusion, leading to hypertension and multi-organ injury, with potential fetal growth restriction and stillbirth. While prophylactic low-dose aspirin can reduce the risk of preterm pre-eclampsia, there are currently no curative treatments once pre-eclampsia is diagnosed except for delivery. Ongoing studies are evaluating various strategies and drugs to prevent and manage pre-eclampsia.

LANCET (2021)

Article Peripheral Vascular Disease

Combining Biomarkers to Predict Pregnancy Complications and Redefine Preeclampsia

Holger Stepan et al.

HYPERTENSION (2020)

Article Obstetrics & Gynecology

Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia

Pooneh Nikuei et al.

BMC PREGNANCY AND CHILDBIRTH (2020)

Review Obstetrics & Gynecology

Placental growth factor in suspected preterm pre-eclampsia: a review of the evidence and practicalities of implementation

A. Hurrell et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2020)

Article Obstetrics & Gynecology

Gestational Hypertension and Preeclampsia

Jimmy Espinoza et al.

OBSTETRICS AND GYNECOLOGY (2020)

Review Obstetrics & Gynecology

Diagnostic utility of angiogenic biomarkers in pregnant women with suspected preeclampsia: A health economics review

Dietmar Schlembach et al.

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH (2019)

Review Peripheral Vascular Disease

Anti-angiogenesis and Preeclampsia in 2016

Susanne Schrey-Petersen et al.

CURRENT HYPERTENSION REPORTS (2017)

Article Medicine, General & Internal

Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia

Harald Zeisler et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Public, Environmental & Occupational Health

Global causes of maternal death: a WHO systematic analysis

Lale Say et al.

LANCET GLOBAL HEALTH (2014)

Article Urology & Nephrology

Chronic kidney disease may be differentially diagnosed from preeclampsia by serum biomarkers

Alessandro Rolfo et al.

KIDNEY INTERNATIONAL (2013)

Review Obstetrics & Gynecology

Maternal Preeclampsia and Neonatal Outcomes

Carl H. Backes et al.

JOURNAL OF PREGNANCY (2011)

Review Developmental Biology

Remodelling at the maternal-fetal interface: relevance to human pregnancy disorders

Judith E. Cartwright et al.

REPRODUCTION (2010)

Review Obstetrics & Gynecology

Are tests for predicting pre-eclampsia good enough to make screening viable? A review of reviews and critical appraisal

Jeltsje S. Cnossen et al.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2009)