4.7 Article

Sensitivity enhanced tunable plasmonic biosensor using two-dimensional twisted bilayer graphene superlattice

Journal

NANOPHOTONICS
Volume 12, Issue 7, Pages 1271-1284

Publisher

WALTER DE GRUYTER GMBH
DOI: 10.1515/nanoph-2022-0798

Keywords

GH shift; human hemoglobin; SARS-CoV-2; sensitivity enhancement; tunable plasmonic biosensor; twisted bilayer graphene superlattice

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This study presents a new design for a tunable plasmonic biosensor using a twisted bilayer graphene (TBG) superlattice and a plasmonic gold thin film. The biosensor can achieve ultrasensitive biosensing through modulation of the Goos-Hanchen (GH) shift. The optimized configuration of the biosensor demonstrates a theoretical possibility for quantitative monitoring of SARS-CoV-2 and human hemoglobin, showing potential for biomedical applications.
This study theoretically demonstrated an insight for designing a novel tunable plasmonic biosensor, which was created by simply stacking a twisted bilayer graphene (TBG) superlattice onto a plasmonic gold thin film. To achieve ultrasensitive biosensing, the plasmonic biosensor was modulated by Goos-Hanchen (GH) shift. Interestingly, our proposed biosensor exhibited tunable biosensing ability, largely depending on the twisted angle. When the relative twisted angle was optimized to be 55.3 degrees, such a configuration: 44 nm Au film/1-TBG superlattice could produce an ultralow reflectivity of 2.2038 x 10(-9) and ultra-large GH shift of 4.4785 x 10(4) mu m. For a small refractive index (RI) increment of 0.0012 RIU (refractive index unit) in sensing interface, the optimal configuration could offer an ultra-high GH shift detection sensitivity of 3.9570 x 10(7) mu m/RIU. More importantly, the optimal plasmonic configuration demonstrated a theoretical possibility of quantitatively monitoring severe acute respiratory syndrome coronavirus (SARS-CoV-2) and human hemoglobin. Considering an extremely small RI change as little as 3 x 10(-7) RIU, a good linear response between detection concentration of SARS-CoV-2 and changes in differential GH shift was studied. For SARS-CoV-2, a linear detection interval was obtained from 0 to 2 nM. For human hemoglobin, a linear detection range was achieved from 0 to 0.002 g/L. Our work will be important to develop novel TBG-enhanced biosensors for quantitatively detecting microorganisms and biomolecules in biomedical application.

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