4.2 Article

Factors associated with the composition of the gut microbiome in patients with established rheumatoid arthritis and its value for predicting treatment responses

Related references

Note: Only part of the references are listed.
Article Rheumatology

Rheumatoid arthritis is associated with increased gut permeability and bacterial translocation that are reversed by inflammation control

Rachel Audo et al.

Summary: This study found that RA patients have altered colonic tight junction proteins and increased serum biomarkers of intestinal permeability. These results suggest a link between impaired gut integrity and systemic inflammation in RA.

RHEUMATOLOGY (2023)

Article Medicine, Research & Experimental

Attributes of intestinal microbiota composition and their correlation with clinical primary non-response to anti-TNF-α agents in inflammatory bowel disease patients

Hanan Alatawi et al.

Summary: The study aims to examine the impact of gut microbiota on primary non-responder patients and identify microbiota as biomarkers for unresponsiveness to anti-TNF-α therapy. Differences in gut microbiome composition were observed between non-responsive and responsive patients, with decreased abundance of SCFA-producing bacteria in non-responsive patients. Signature biomarkers were identified as predictors of clinical non-response.

BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES (2022)

Article Immunology

The Gut Microbiome and Metabolites Are Altered and Interrelated in Patients With Rheumatoid Arthritis

Die Yu et al.

Summary: In this study, the relationship among gut microbiome, fecal metabolites, and rheumatoid arthritis (RA) was systematically evaluated. The abundance of certain genera and the levels of specific metabolites were found to be significantly altered in RA patients compared to healthy controls. The study also demonstrated the interconnectedness of the gut microbiome and metabolites in RA patients, with Escherichia being identified as the core genera. Overall, this research provides important insights into the pathogenesis of RA and potential targeted therapies.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Article Multidisciplinary Sciences

Intestinal butyrate-metabolizing species contribute to autoantibody production and bone erosion in rheumatoid arthritis

Jing He et al.

Summary: This study reveals the imbalance between butyrate-producing and butyrate-consuming species in rheumatoid arthritis patients. It shows that butyrate promotes the production of T-regs and reduces inflammation. Butyrate supplementation can alleviate inflammation by rebalancing immune cells and reducing antibody production.

SCIENCE ADVANCES (2022)

Article Multidisciplinary Sciences

Differential effects of periodontal microbiome on the rheumatoid factor induction during rheumatoid arthritis pathogenesis

Ji-Won Kim et al.

Summary: Periodontal bacteria may shape RF status by affecting the humoral immune response during RA pathogenesis.

SCIENTIFIC REPORTS (2022)

Article Microbiology

Bacterial Compositional Shifts of Gut Microbiomes in Patients with Rheumatoid Arthritis in Association with Disease Activity

Nagwan G. El Menofy et al.

Summary: This study identified significant differences in gut microbiomes between rheumatoid arthritis (RA) patients and healthy individuals, and found a direct association between bacterial diversity and disease activity in RA patients. Genus-level analysis revealed a positive coexistence between RA and certain genera. Furthermore, correlation analysis classified the dominant genera into distinct clusters based on disease activity. The predictive metabolic profile of bacterial communities associated with RA supports the potential impact of gut microbiomes on the development or recovery of RA.

MICROORGANISMS (2022)

Review Medicine, Research & Experimental

Troublesome friends within us: the role of gut microbiota on rheumatoid arthritis etiopathogenesis and its clinical and therapeutic relevance

Zyanya Reyes-Castillo et al.

Summary: The gut microbiota plays a crucial role in immune regulation and the development of autoimmune diseases such as rheumatoid arthritis (RA), with research into this area being a recent focus. Multiple studies have shown alterations in the composition and/or function of gut microbiota in early and established RA patients, but the molecular mechanisms behind how gut microorganisms induce immune tolerance loss or contribute to disease progression are still poorly understood.

CLINICAL AND EXPERIMENTAL MEDICINE (2021)

Article Rheumatology

Dysbiosis in the oral microbiomes of anti-CCP positive individuals at risk of developing rheumatoid arthritis

Zijian Cheng et al.

Summary: This study found that anti-CCP positive at-risk individuals have dysbiotic subgingival microbiomes and increased abundance of P. gingivalis compared with controls. This supports the hypothesis that the oral microbiome, specifically P. gingivalis, plays an important role in the initiation of RA.

ANNALS OF THE RHEUMATIC DISEASES (2021)

Article Rheumatology

The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis

Alejandro Artacho et al.

Summary: This study investigated the potential of the human gut microbiome in predicting methotrexate (MTX) efficacy in new-onset rheumatoid arthritis (RA) patients. The analysis revealed significant associations between gut bacterial taxa abundance and genes with future clinical response, as well as a microbiome-based model that predicted lack of response to MTX. Ex vivo experiments also suggested a possible direct effect of the gut microbiome on MTX metabolism and treatment outcomes, supporting the value of the gut microbiome as a potential prognostic tool and therapeutic target in RA.

ARTHRITIS & RHEUMATOLOGY (2021)

Article Rheumatology

Differences in the Oral Microbiome in Patients With Early Rheumatoid Arthritis and Individuals at Risk of Rheumatoid Arthritis Compared to Healthy Individuals

Johanna M. Kroese et al.

Summary: The study found similarities in the oral microbiome between patients with early RA and individuals at risk of developing RA, as both groups showed an increased relative abundance of potentially proinflammatory species compared to healthy controls. These findings suggest a possible association between the oral microbiome and the onset of RA.

ARTHRITIS & RHEUMATOLOGY (2021)

Review Immunology

The etiology of rheumatoid arthritis

Hans Ulrich Scherer et al.

JOURNAL OF AUTOIMMUNITY (2020)

Review Rheumatology

The genetics of rheumatoid arthritis

Laura E. Dedmon

RHEUMATOLOGY (2020)

Review Cell Biology

The Role of the Microbiome in Driving RA-Related Autoimmunity

Cristopher M. Rooney et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Gastroenterology & Hepatology

From correlation to causality: the case of Subdoligranulum

Matthias Van Hul et al.

GUT MICROBES (2020)

Article Rheumatology

Prevotella copri in individuals at risk for rheumatoid arthritis

Deshire Alpizar-Rodriguez et al.

ANNALS OF THE RHEUMATIC DISEASES (2019)

Letter Biotechnology & Applied Microbiology

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

Evan Bolyen et al.

NATURE BIOTECHNOLOGY (2019)

Article Multidisciplinary Sciences

Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide

Matthew T. Henke et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Biochemistry & Molecular Biology

Host-microbiota interactions in rheumatoid arthritis

Yuichi Maeda et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

Review Rheumatology

The microbiome and rheumatoid arthritis

Anne-Sophie Bergot et al.

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2019)

Article Medicine, General & Internal

Rheumatoid arthritis

Josef S. Smolen et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

Article Biochemistry & Molecular Biology

Analysis of Gut Microbiota in Rheumatoid Arthritis Patients: Disease-Related Dysbiosis and Modifications Induced by Etanercept

Andrea Picchianti-Diamanti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemical Research Methods

Calypso: a user-friendly web-server for mining and visualizing microbiome-environment interactions

Martha Zakrzewski et al.

BIOINFORMATICS (2017)

Meeting Abstract Orthopedics

ALTERATIONS OF GUT MICROBIOME IN RHEUMATOID ARTHRITIS

X. Wu et al.

OSTEOARTHRITIS AND CARTILAGE (2017)

Article Rheumatology

Faecal microbiota study reveals specific dysbiosis in spondyloarthritis

Maxime Breban et al.

ANNALS OF THE RHEUMATIC DISEASES (2017)

Article Gastroenterology & Hepatology

A Single Species of Clostridium Subcluster XIVa Decreased in Ulcerative Colitis Patients

Kozue Takeshita et al.

INFLAMMATORY BOWEL DISEASES (2016)

Article Genetics & Heredity

An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis

Jun Chen et al.

GENOME MEDICINE (2016)

Article Biochemistry & Molecular Biology

The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

Xuan Zhang et al.

NATURE MEDICINE (2015)

Article Multidisciplinary Sciences

Utilisation of Mucin Glycans by the Human Gut Symbiont Ruminococcus gnavus Is Strain-Dependent

Emmanuelle H. Crost et al.

PLOS ONE (2013)

Article Immunology

Porphyromonas gingivalis promotes Th17 inducing pathways in chronic periodontitis

Niki M. Moutsopoulos et al.

JOURNAL OF AUTOIMMUNITY (2012)

Article Pharmacology & Pharmacy

The influence of probiotic treatment on sulfasalazine metabolism in rat

Hee Ji Lee et al.

XENOBIOTICA (2012)

Article Biochemistry & Molecular Biology

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivaylo I. Ivanov et al.

Article Medicine, Research & Experimental

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

Shahla Abdollahi-Roodsaz et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)