Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green

Technology for generating especially important amide and peptide bonds from carboxylic acids and amines that avoids traditional coupling reagents is described. The 1-pot processes developed rely on thioester formation, neat, using a simple dithiocarbamate, and are safe and green, and rely on Nature-inspired thioesters that are then converted to the targeted functionality.

Automated summary

This passage describes a new technology for generating amide and peptide bonds from carboxylic acids and amines without traditional coupling reagents. The one-pot processes rely on the formation of thioesters using a simple dithiocarbamate, which are safe, green, and inspired by nature, and then converted to the desired functionality.