☆ 4.7 Article

Ginseng-Containing Sijunzi Decoction Ameliorates Ulcerative Colitis by Orchestrating Gut Homeostasis in Microbial Modulation and Intestinal Barrier Integrity

AMERICAN JOURNAL OF CHINESE MEDICINE (2023)

Related references

Note: Only part of the references are listed.

Article Integrative & Complementary Medicine

Atractylodes lancea Rhizoma Attenuates DSS-Induced Colitis by Regulating Intestinal Flora and Metabolites

Linghang Qu et al.

Summary: This study compared the therapeutic effects and mechanisms of raw Atractylodes lancea and bran-fried Atractylodes lancea on dextran sulfate sodium-induced ulcerative colitis in mice. The results showed that both preparations alleviated colitis symptoms, inhibited inflammation and restored gut microbial balance. Bran-fried Atractylodes lancea had a better therapeutic effect than raw Atractylodes lancea.

AMERICAN JOURNAL OF CHINESE MEDICINE (2022)

Add to Collection

Review Gastroenterology & Hepatology

Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology

Claudia D. Fuchs et al.

Summary: Bile acids play a crucial role in regulating metabolism and homeostasis, and their disrupted balance can contribute to gastrointestinal and liver diseases. Targeting bile acid pathways may provide novel treatment strategies for these disorders.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

Add to Collection

Article Gastroenterology & Hepatology

What to do about the leaky gut

Michael Camilleri et al.

GUT (2022)

Add to Collection

Article Pharmacology & Pharmacy

Gut microbiota induces DNA methylation via SCFAs predisposing obesity-prone individuals to diabetes

Wenqian Guo et al.

Summary: This study revealed that obesity-prone individuals show diabetes-related DNA methylation signatures even when they have normal weight and BMI. The gut microbiota and microbial-derived short-chain fatty acids (SCFAs) were found to play a significant role in inducing DNA methylation and predisposing individuals to diabetes.

PHARMACOLOGICAL RESEARCH (2022)

Add to Collection

Article Multidisciplinary Sciences

Mannose ameliorates experimental colitis by protecting intestinal barrier integrity

Lijun Dong et al.

Summary: The study shows that mannose supplementation can alleviate symptoms of inflammatory bowel disease, including colitis. It improves intestinal barrier integrity, reduces the release of proteins, and prevents mitochondrial dysfunction. Mannose also synergizes with the conventional drug mesalamine in colitis treatment.

NATURE COMMUNICATIONS (2022)

Add to Collection

Review Medicine, General & Internal

Systematic review of donor and recipient predictive biomarkers of response to faecal microbiota transplantation in patients with ulcerative colitis

Nia Paddison Rees et al.

Summary: This systematic review aims to identify clinical, microbial, and metabolomic biomarkers in donors and recipients that predict the response to FMT in UC. The results suggest that distinct changes in gut microbiota profiles, along with specific baseline characteristics and microbial and metabolomic alterations, may predispose patients towards a successful therapeutic outcome.

EBIOMEDICINE (2022)

Add to Collection

Review Microbiology

Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer

John Gubatan et al.

Summary: The gut microbiome is crucial in inflammatory bowel disease. Fecal microbial transplants and dietary interventions have been investigated as therapeutic strategies. The gut microbiota composition can be influenced by specific nutrition and diet. Furthermore, the gut microbiome may play a significant role in the development of colitis-associated colon cancer.

MICROORGANISMS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection

Daping Yang et al.

Summary: Neuroepithelial crosstalk plays a critical role in gut physiology, particularly in mediating gut barrier protection. Sensory neurons communicate with intestinal goblet cells to promote mucus secretion and gut protection via the CGRP-Ramp1 pathway. Additionally, commensal microbes can activate nociceptors to regulate CGRP release.

CELL (2022)

Add to Collection

Article Pharmacology & Pharmacy

Discoidin domain receptor 1(DDR1) promote intestinal barrier disruption in Ulcerative Colitis through tight junction proteins degradation and epithelium apoptosis

Xiaoli Li et al.

Summary: This study reveals that DDR1 regulates the intestinal barrier in colitis by modulating TJ proteins expression and epithelium apoptosis. In DSS-induced colitis, DDR1(-/-) mice showed alleviated intestinal mucosal barrier injuries, upregulated TJ proteins, decreased epithelium apoptosis, and reduced proinflammatory cytokines production.

PHARMACOLOGICAL RESEARCH (2022)

Add to Collection

Article Endocrinology & Metabolism

Metabolic Messengers: bile acids

Alessia Perino et al.

Summary: Bile acids are amphipathic steroid acids that play a crucial role in the regulation of metabolic responses. Their actions through activation of specific receptors control energy homeostasis and alterations in bile acid signaling are associated with metabolic diseases. Modulation of the bile acid pool could be a potential therapeutic approach.

NATURE METABOLISM (2022)

Add to Collection

Review Microbiology

Gut microbial metabolites as multi-kingdom intermediates

Kimberly A. Krautkramer et al.

Summary: The gut microbiota influences host physiology through the production of various metabolites. By studying microbial metabolites, researchers have identified potential microbial targets relevant for host health, despite the challenges of understanding host-microbiota interactions.

NATURE REVIEWS MICROBIOLOGY (2021)

Add to Collection

Review Cell Biology

Targeting the alternative bile acid synthetic pathway for metabolic diseases

Wei Jia et al.

Summary: The gut microbiota plays a significant role in glucose and lipid metabolism by regulating bile acid metabolism and affecting multiple signaling pathways. Bile acids are synthesized in the liver through two distinct pathways, influencing cholesterol and lipid catabolism and activating various signaling pathways. Modulating bile acid synthesis and composition could be a novel approach for developing therapies for metabolic diseases.

PROTEIN & CELL (2021)

Add to Collection

Article Integrative & Complementary Medicine

Intestinal Flora: A Pivotal Role in Investigation of Traditional Chinese Medicine

Xiao Li et al.

Summary: The interaction between intestinal flora and Traditional Chinese Medicine (TCM) is crucial for host health and has become an important research field in life science. The significance of intestinal flora is increasingly validated by more TCM research, while also showcasing the wisdom and foresight of TCM.

AMERICAN JOURNAL OF CHINESE MEDICINE (2021)

Add to Collection

Review Medicine, Research & Experimental

New Therapeutics for Ulcerative Colitis

Robert P. Hirten et al.

Summary: This review explores novel therapeutic approaches to UC, including promising drugs, efforts to maximize the efficacy of currently available treatment options, and non-medication-based modalities. Treatment approaches which show promise in impacting the future of UC management are highlighted.

ANNUAL REVIEW OF MEDICINE, VOL 72, 2021 (2021)

Add to Collection

Article Plant Sciences

Differential effect of polysaccharide and nonpolysaccharide components in Sijunzi decoction on spleen deficiency syndrome and their mechanisms

Ping Ma et al.

Summary: The study revealed that Sijunzi decoction (SJZD) has a stronger therapeutic effect on intestinal immune and GI hormone secretion in SDS rats, while the effectiveness of NPS and S-3 showed slight differences. NPS mainly regulates GI hormone secretion and directly improves intestinal immunity, whereas S-3 enhances intestinal immunity by increasing T lymphocyte cell expression and repairing the intestinal barrier directly and indirectly. Additionally, the modulation effect of the gut microbiota plays a crucial role in the treatment of SDS with SJZD, NPS, and S-3.

PHYTOMEDICINE (2021)

Add to Collection

Article Biochemical Research Methods

An integrated strategy of MS-network-based offline 2DLC-QTOF-MS/MS coupled with UHPLC-QTRAP®-MS/MS for the characterization and quantification of the non-polysaccharides in Sijunzi decoction

Bangjian Dong et al.

Summary: This study comprehensively analyzed the non-polysaccharide components of Sijunzi decoction using advanced techniques, identifying 449 components, including potentially novel substances. By establishing an MS-network of SJZD and quantifying 19 representative components using UHPLC-QTRAP®-MS/MS, the pharmacological effects and action mechanism of SJZD were further understood.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis

Jian Fang et al.

Summary: By reviewing the interactions between gut microbiome and the mucus layer, this article sheds light on the potential for developing new treatments for ulcerative colitis (UC). Understanding the bidirectional communication between the gut microbiota and the colon's mucus layer is crucial in addressing the imbalance that leads to UC. The mucus layers play a key role in nourishing 'good' microbes while excluding pathogens, and disruptions in this balance may result in inflammatory bowel diseases.

EXPERIMENTAL AND MOLECULAR MEDICINE (2021)

Add to Collection

Article Gastroenterology & Hepatology

Dynamic Properties of the Intestinal Ecosystem Call for Combination Therapies, Targeting Inflammation and Microbiota, in Ulcerative Colitis

Maarten van de Guchte et al.

Summary: The study indicates the existence of multiple microbiota states and host states in the intestinal ecosystem, with improvements in inflammatory status being accompanied by improvements in microbiota status but hindered by barriers posed by alternative states.

GASTROENTEROLOGY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Dissecting the Interplay Mechanism between Epigenetics and Gut Microbiota: Health Maintenance and Disease Prevention

Yuqi Wu et al.

Summary: The interplay between gut microbiota and host epigenetics has significant impacts on health and disease by regulating various epigenetic pathways to achieve biological functions, including modulating intestinal inflammation, improving metabolic disturbances, and inhibiting colitis events.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Nutrition & Dietetics

Diet and gut microbiota manipulation for the management of Crohn's disease and ulcerative colitis

Vaios Svolos et al.

Summary: The etiology of IBD involves multiple factors, with diet and gut microbiota playing crucial roles in disease management. Clinical trials focusing on the effects of EEN on gut microbiota in children with CD offer insights into disease pathogenesis, while evidence linking food-based dietary therapies for IBD with gut microbiota mechanisms remains inconclusive.

PROCEEDINGS OF THE NUTRITION SOCIETY (2021)

Add to Collection

Review Integrative & Complementary Medicine

Colorectal Cancer, Gut Microbiota and Traditional Chinese Medicine: A Systematic Review

Hui Zhao et al.

Summary: The text discusses the pathogenesis of colorectal cancer, the types and functions of gut microbiota, and the research on traditional Chinese medicine in treating colorectal cancer by regulating the gut microbiota. It emphasizes the importance of regulating the gut microbiota for disease treatment.

AMERICAN JOURNAL OF CHINESE MEDICINE (2021)

Add to Collection

Article Oncology

Chinmedomics facilitated quality-marker discovery of Sijunzi decoction to treat spleen qi deficiency syndrome

Qiqi Zhao et al.

FRONTIERS OF MEDICINE (2020)

Add to Collection

Article Multidisciplinary Sciences

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

Xinyang Song et al.

NATURE (2020)

Add to Collection

Article Gastroenterology & Hepatology

Microbial imbalance in inflammatory bowel disease patients at different taxonomic levels

Mohammad Tauqeer Alam et al.

GUT PATHOGENS (2020)

Add to Collection

Editorial Material Gastroenterology & Hepatology

Global burden of inflammatory bowel disease

Vipul Jairath et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

Add to Collection

Article Medicine, Research & Experimental

Modified Sijunzi decoction in the treatment of ulcerative colitis in the remission phase: study protocol for a series of N-of-1 double-blind, randomised controlled trials

Yi-ming Chen et al.

TRIALS (2020)

Add to Collection

Letter Biotechnology & Applied Microbiology

PICRUSt2 for prediction of metagenome functions

Gavin M. Douglas et al.

NATURE BIOTECHNOLOGY (2020)

Add to Collection

Article Medicine, Research & Experimental

Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice

Preeti Raju et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Add to Collection

Article Medicine, General & Internal

Ulcerative colitis

Taku Kobayashi et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

Add to Collection

Editorial Material Gastroenterology & Hepatology

FMT for ulcerative colitis: closer to the turning point

Giovanni Cammarota et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Add to Collection

Article Multidisciplinary Sciences

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

Jason Lloyd-Price et al.

NATURE (2019)

Add to Collection

Article Immunology

Genistein protects against DSS-induced colitis by inhibiting NLRP3 inflammasome via TGR5-cAMP signaling

Yu Chen et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

Add to Collection

Review Immunology

Targeting immune cell circuits and trafficking in inflammatory bowel disease

Markus F. Neurath

NATURE IMMUNOLOGY (2019)

Add to Collection

Article Pharmacology & Pharmacy

Network pharmacology based investigation into the effect and mechanism of Modified Sijunzi Decoction against the subtypes of chronic atrophic gastritis

Guihua Tian et al.

PHARMACOLOGICAL RESEARCH (2019)

Add to Collection

Article Medicine, General & Internal

Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis A Randomized Clinical Trial

Samuel P. Costello et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

Add to Collection

Article Gastroenterology & Hepatology

Tauroursodeoxycholic acid attenuates colitis-associated colon cancer by inhibiting nuclear factor kappaB signaling

Young Hoon Kim et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2019)

Add to Collection

Article Microbiology

Gut microbiome structure and metabolic activity in inflammatory bowel disease

Eric A. Franzosa et al.

NATURE MICROBIOLOGY (2019)

Add to Collection

Review Gastroenterology & Hepatology

Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

Wei Jia et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

Add to Collection

Review Gastroenterology & Hepatology

Combining Biologics in Inflammatory Bowel Disease and Other Immune Mediated Inflammatory Disorders

Robert P. Hirten et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2018)

Add to Collection

Article Plant Sciences

Effects of a homogeneous polysaccharide from Sijunzi decoction on human intestinal microbes and short chain fatty acids in vitro

Beibei Gao et al.

JOURNAL OF ETHNOPHARMACOLOGY (2018)

Add to Collection

Article Medicine, General & Internal

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

Siew C. Ng et al.

LANCET (2017)

Add to Collection

Review Medicine, General & Internal

Ulcerative colitis

Ryan Ungaro et al.

LANCET (2017)

Add to Collection

Article Multidisciplinary Sciences

The evolution of the host microbiome as an ecosystem on a leash

Kevin R. Foster et al.

NATURE (2017)

Add to Collection

Article Biotechnology & Applied Microbiology

Ursodeoxycholic Acid and Its Taurine- or Glycine-Conjugated Species Reduce Colitogenic Dysbiosis and Equally Suppress Experimental Colitis in Mice

Lien Van den Bossche et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2017)

Add to Collection

Article Integrative & Complementary Medicine

Sijunzi Decoction attenuates 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)induced colitis in rats and ameliorates TNBS-induced claudin-2 damage via NF-κB pathway in Caco2 cells

Yue Lu et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017)

Add to Collection

Review Cell Biology

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

Annika Wahlstrom et al.

CELL METABOLISM (2016)

Add to Collection

Article Medicine, Research & Experimental

Effects of the Sijunzi decoction on the immunological function in rats with dextran sulfate-induced ulcerative colitis

Wangui Yu et al.

BIOMEDICAL REPORTS (2016)

Add to Collection

Article Cell Biology

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

Sama I. Sayin et al.

CELL METABOLISM (2013)

Add to Collection

Article Multidisciplinary Sciences

A microbial symbiosis factor prevents intestinal inflammatory disease

Sarkis K. Mazmanian et al.

NATURE (2008)

Add to Collection

Article Gastroenterology & Hepatology

Microbial diversity of inflamed and noninflamed gut biopsy tissues in inflammatory bowel disease

Shadi Sepehri et al.

INFLAMMATORY BOWEL DISEASES (2007)

Add to Collection

© Peeref 2019-2024. All rights reserved.