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Recent Advances of DNA Origami Technology and Its Application in Nanomaterial Preparation

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SMALL STRUCTURES
Volume -, Issue -, Pages -

Publisher

WILEY
DOI: 10.1002/sstr.202200376

Keywords

DNA nanostructures; DNA origami; nanomaterial preparations; self-assemblies

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In recent years, the development of DNA self-assembly technology has fueled the advancement of DNA origami technology. This technology enables the construction of DNA nanostructures with different shapes, which find wide applications in nanomaterial preparation and drug delivery. These structures possess accurate addressability, excellent programmability, and good biocompatibility, providing a highly precise platform for nanomaterial fabrication.
In recent years, the unrivalled self-assembly properties of DNA molecules have driven the rapid development of a new class of DNA self-assembly technology DNA origami technology. Over the past decade, this technology has enabled the construction of DNA nanostructures with different shapes, such as 2D and 3D structures. Meanwhile, the application of DNA origami are also developed rapidly. DNA origami structures are widely used in nanomaterial preparation and drug delivery due to their characteristics of accurate addressability, excellent programmability, and good biocompatibility, especially in the field of nanomaterial preparation. Such structures provide a new platform to construct nanomaterials with high precision. Herein, the development of DNA origami technology is introduced, and the research progress of 2D and 3D DNA origami in the past two decades is systematically summarized. Then, the application of DNA origami template in nanomaterial preparation is emphasized. Finally, the main challenges and opportunities for nanomaterials fabrication based on DNA origami technology are illustrated.

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