Different Dimensions of the Effects of SARS-CoV-2 in Causing Fluctuations in the Blood Pressure of Patients

In late 2019, SARS-CoV-2 was transmitted from animal to human in China. Subsequently, the virus spread rapidly throughout the world by human-to-human transmission and caused high mortality the people with underlying diseases, especially hypertension. This virus binds to its receptor, angiotensin-converting enzyme-2 (ACE2), via the S protein. ACE2 has a negative regulatory function in the renin-angiotensin system (RAS) and degrades angiotensin 2 (Ang II) as a vasoconstrictor which causes blood pressure regulation. It also converts Ang II to Ang1-7, which has anti-inflammatory and anti-oxidative effects. SARS-CoV-2 infection in patients with hypertension reduces ACE2 levels due to virus binding, which decreases Ang II degradation. Consequently, the complications associated with hypertension are raised, and blood pumping from the lungs into the left atrium lowers. On the other hand, the final product, Ang1-7, is reduced, and its related anti-inflammatory activity is also eliminated. The virus multiplies and damages lung cells, causing inflammation and edema of the lung tissue through the function of immune cells and cytokines, which eventually leads to lung damage, reduced oxygen delivery, and death. Careful care of patients with hypertension can prevent their infection and reduce their death with appropriate oxygen therapy and possibly using exogenous ACE2 supplements.

Automated summary

SARS-CoV-2 in China originated from animal to human transmission in late 2019. It quickly spread worldwide through human-to-human transmission, resulting in high mortality, especially among people with underlying diseases like hypertension. The virus binds to ACE2, a receptor that regulates the renin-angiotensin system and degrades vasoconstrictor angiotensin 2 (Ang II). Infection reduces ACE2 levels, leading to decreased Ang II degradation and increased complications associated with hypertension. Additionally, the anti-inflammatory effects of Ang1-7 are diminished. Lung damage and reduced oxygen delivery occur due to viral multiplication, inflammation, and edema of lung tissue. Careful management of hypertension patients can prevent infection and possibly reduce mortality with oxygen therapy and exogenous ACE2 supplements.