Journal
EUROPEAN JOURNAL OF PEDIATRICS
Volume 182, Issue 3, Pages 1429-1432Publisher
SPRINGER
DOI: 10.1007/s00431-022-04789-x
Keywords
Leishmania; CD38 cells; HLH; Hemophagocytosis; Children
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Leishmaniasis is linked to HLH, and the measurement of CD8(+) CD38(high)/HLA-DR+ T cells is crucial in distinguishing HLH from sepsis or healthy individuals in children presenting with shock and organ failure.
Leishmaniasis is a cause of infection associated with hemophagocytic lymphohistiocytosis (HLH). The measurement of the CD8(+) CD38(high)/HLA-DR+ T cells in children presenting with acute onset of shock and multisystem organ failure represents an important parameter to distinguish HLH from sepsis or healthy control. Conclusion: We report a case series of 4 Italian children suffering from HLH secondary to visceral Leishmaniasis in which the lymphocyte subset assay suggests a potential role of CD38(high)/HLA-DR+ CD8(+) T cells as HLH diagnostic biomarkers.
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