Journal
ORGANIC LETTERS
Volume 25, Issue 9, Pages 1569-1572Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c004151569Org
Keywords
-
Categories
Ask authors/readers for more resources
N-Trifluoroacetylated sulfoximines react with 1-trifluoromethylstyrenes in a one-pot domino reaction to give fluorinated 5,6-dihydro-1,2-thiazine 1-oxides in good to high yields. The reaction involves nucleophilic allylic substitution, hydrolysis, and intramolecular nucleophilic vinylic substitution. The resulting product's molecular structure was confirmed by X-ray crystallographic analysis.
N-Trifluoroacetylated (N-TFA) sulfoximines react with 1-trifluoromethylstyrenes in a one-pot domino reaction to give fluorinated 5,6-dihydro-1,2-thiazine 1-oxides in good to high yields. The process involves three sequential reaction steps that can be characterized as (1) nucleophilic allylic substitution (SN2 '), (2) hydrolysis, and (3) intramolecular nucleophilic vinylic substitution (SNV). The products can further be modified by defluorination. The molecular structure of the resulting product was confirmed by X-ray crystallographic analysis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available