Unlocking Regiodivergence in PdII- and RhIII-Mediated Site-Selective C-H Bond Alkynylation of Imidazopyridines

An efficient PdII- and RhIII-controlled site-selective C-H bond alkynylation of imidazopyridines using (bromoethynyl)triisopropylsilane is disclosed. The divergent methodology allows straightforward access to a wide range of products alkynylated at the C3 and ortho positions. This strategy is suggestive of a practical platform that can be suitable for late -stage diversification and may assist in the design of more selective and complementary catalytic systems.

Automated summary

An efficient method for site-selective C-H bond alkynylation of imidazopyridines using (bromoethynyl)triisopropylsilane controlled by PdII and RhIII is disclosed. The divergent approach allows easy access to a range of alkynylated products at the C3 and ortho positions. This strategy may have practical implications for late-stage diversification and the development of more selective and complementary catalytic systems.