Related references
Note: Only part of the references are listed.Gramicidin A accumulates in mitochondria, reduces ATP levels, induces mitophagy, and inhibits cancer cell growth
Yun-Wei Xue et al.
CHEMICAL SCIENCE (2022)
Vectorial insertion of a β-helical peptide into membrane: a theoretical study on polytheonamide B
Mahroof Kalathingal et al.
BIOPHYSICAL JOURNAL (2021)
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
David J. Newman et al.
JOURNAL OF NATURAL PRODUCTS (2020)
Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics
Laura C. Watkins et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
The quest for supernatural products: the impact of total synthesis in complex natural products medicinal chemistry
Zhi-Chen Wu et al.
NATURAL PRODUCT REPORTS (2020)
Comprehensive Structure-Activity Relationship Studies of Macrocyclic Natural Products Enabled by Their Total Syntheses
Hiroaki Itoh et al.
CHEMICAL REVIEWS (2019)
The Current State of Peptide Drug Discovery: Back to the Future?
Antoine Henninot et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Controllable synthetic ion channels
Jian-Yu Chen et al.
ORGANIC CHEMISTRY FRONTIERS (2018)
Solid-Phase Total Synthesis and Dual Mechanism of Action of the Channel-Forming 48-mer Peptide Polytheonamide B
Atsushi Hayata et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters
Jessica L. Thomaston et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium
Michael F. Freeman et al.
NATURE CHEMISTRY (2017)
Dual Chemical Modification of a Polytheonamide Mimic: Rational Design and Synthesis of Ion-Channel-Forming 48-mer Peptides with Potent Cytotoxicity
Atsushi Hayata et al.
CHEMISTRY-A EUROPEAN JOURNAL (2016)
Rectified Proton Grotthuss Conduction Across a Long Water-Wire in the Test Nanotube of the Polytheonamide B Channel
Yuka Matsuki et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
Imaging lipid order changes in endosome membranes of live cells by using a Nile Red-based membrane probe
Zeinab Darwich et al.
RSC ADVANCES (2014)
Paradoxical One-ion Pore Behavior of the Long β-Helical Peptide of Marine Cytotoxic Polytheonamide B
Masayuki Iwamoto et al.
SCIENTIFIC REPORTS (2014)
Chemical Construction and Structural Permutation of Potent Cytotoxin Polytheonamide B: Discovery of Artificial Peptides with Distinct Functions
Hiroaki Itoh et al.
ACCOUNTS OF CHEMICAL RESEARCH (2013)
Lysosomal Acidification Mechanisms
Joseph A. Mindell
ANNUAL REVIEW OF PHYSIOLOGY, VOL 74 (2012)
Selective Modification of the N-Terminal Structure of Polytheonamide B Significantly Changes its Cytotoxicity and Activity as an Ion Channel
Naoki Shinohara et al.
CHEMMEDCHEM (2012)
Design, Synthesis and Functional Analysis of Dansylated Polytheonamide Mimic: An Artificial Peptide Ion Channel
Hiroaki Itoh et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Functional Analysis of Synthetic Substructures of Polytheonamide B: A Transmembrane Channel-Forming Peptide
Shigeru Matsuoka et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Dynamic structure of the polytheonamide B channel studied by normal mode analysis
Takaharu Mori et al.
MOLECULAR SIMULATION (2011)
Probing the Biology of Natural Products: Molecular Editing by Diverted Total Synthesis
Alex M. Szpilman et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
A cytotoxic peptide from a marine sponge exhibits ion channel activity through vectorial-insertion into the membrane
Masayuki Iwamoto et al.
FEBS LETTERS (2010)
Nanoscale Ionic Diodes with Tunable and Switchable Rectifying Behavior
Michael X. Macrae et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Solution Structure of Polytheonamide B, a Highly Cytotoxic Nonribosomal Polypeptide from Marine Sponge
Toshiyuki Hamada et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Sensors and regulators of intracellular pH
Joseph R. Casey et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
A voltage-responding ion channel derived by C-terminal modification of gramicidin a
Philipp Reiss et al.
CHEMBIOCHEM (2008)
Sulforhodamine B colorimetric assay for cytotoxicity screening
Vanicha Vichai et al.
NATURE PROTOCOLS (2006)
Polytheonamides A and B, highly cytotoxic, linear polypeptides with unprecedented structural features, from the marine sponge, Theonella swinhoeiii
T Hamada et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Share Paper
