Novel N(SCF3)(CF3)-amines: synthesis, scalability and stability

We disclosed herein a straightforward strategy for the synthesis of unprecedented N-((trifluoromethyl)thio), N-(trifluoromethyl) amines using a combination of isothiocyanates with a fluoride source and an electrophilic trifluoromethylthiolation reagent. More interestingly, the scalability of the methodology has been demonstrated and the stability of the new motif has been studied.

Automated summary

We present a straightforward strategy for synthesizing unprecedented N-((trifluoromethyl)thio), N-(trifluoromethyl) amines using isothiocyanates, a fluoride source, and an electrophilic trifluoromethylthiolation reagent. The scalability of the methodology has been demonstrated, and the stability of the synthesized motif has been investigated.