4.6 Article

Sodium hypophosphite mediated reductive amination of carbonyl compounds with N,N-dialkylformamides

Journal

NEW JOURNAL OF CHEMISTRY
Volume 47, Issue 14, Pages 6532-6535

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d3nj00728f

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Here, we report a metal- and acid-free protocol for the reductive amination of carbonyl compounds using DMF and a substoichiometric amount of NaH2PO2·H2O. Various N,N-dimethylamines were obtained in moderate to excellent yields without the need for chromatographic purification. The method's trends and limitations with different formamides as sources of dialkyl fragments were explored.
Herein we report a transition-metal- and acid-free protocol for the reductive amination of carbonyl compounds with DMF using a substoichiometric amount of NaH2PO2 center dot H2O. A set of various N,N-dimethylamines were obtained in moderate to excellent yields without chromatographic purification. The general trends and limitations of the method with different formamides as sources of dialkyl-fragments were explored.

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