Recent Progress in Transition Metal Catalyzed C(sp3)-H Nitrene Insertion Reactions Assisted by Directing Groups

The transition metal catalyzed activation of C(sp3)-H bonds to form carbon-nitrogen bonds has been a challenging and hot research area. The transition metal-catalyzed C(sp3)-H amination strategy provides a more direct and efficient way to form C-N bonds. With the vigorous development in the field of C-H bond activation, a variety of directing groups and transition metal catalyst systems have been developed, which provide effective tools for C(sp3)-H amination through the inner sphere mechanism. In recent years, important progress has been made in directing group-assisted C(sp3)-H bond amination reactions, and many catalyst systems based on different transition metals with cheap and efficient amination reagents have been developed. The research progress of transition metal-catalyzed C(sp3)-H nitrene insertion reaction assisted by directing groups in the past decade is reviewed.

Automated summary

Transition metal-catalyzed activation of C(sp3)-H bonds to form carbon-nitrogen bonds is a challenging and hot research area. The C(sp3)-H amination strategy provides a more direct and efficient way to form C-N bonds. Various directing groups and transition metal catalyst systems have been developed, allowing for effective C(sp3)-H amination through the inner sphere mechanism. Recent progress in directing group-assisted C(sp3)-H bond amination reactions, using catalyst systems based on different transition metals and inexpensive amination reagents, is reviewed in this article.