Determination of 24 sulfonamide antibiotics in instant pastries by modifiied QuEChERS coupled with ultra performance liquid chromatography-tandem mass spectrometry

There were few reports about antibiotic residues in egg-containing products. In the study, an effective method for the simultaneous determination of 24 sulfonamide antibiotics in two instant pastries based on a modified QuEChERS sample preparation technique coupled with ultra performance liquid chromatography-tandem mass spectrometry was developed. The results show that the average recoveries of the SAs at 5, 10, and 50 mg kg -1 levels were 67.6%-103.8%, with relative standard deviations (RSD) of 0.80-9.23%. The limit of detections (LODs) and limit of quantitations (LOQs) were 0.01-0.14 mg kg -1 and 0.02-0.45 mg kg -1, respectively. This method was suitable for analysis of 24 SAs in instant pastries.

Automated summary

An effective method was developed for simultaneous determination of 24 sulfonamide antibiotics in two instant pastries. The method showed good recoveries and low variations with LODs and LOQs ranging from 0.01-0.14 mg/kg and 0.02-0.45 mg/kg, respectively. This method is suitable for analysis of sulfonamide antibiotics in instant pastries.