Journal
CLINICAL AND EXPERIMENTAL MEDICINE
Volume -, Issue -, Pages -Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10238-023-01029-w
Keywords
Sepsis; Mortality; Systemic inflammatory immune index; Biomarkers
Categories
Ask authors/readers for more resources
The study aimed to investigate the association between systemic immune-inflammation index (SII) and mortality risk in critically ill patients with sepsis and explore possible tools for rapid screening. The results showed a J-shaped relationship between SII and mortality risk, with the SII level of 774.46*10(9)/L associated with the lowest mortality risk. Low and high SII levels were associated with an increased risk of short-term mortality in critically ill patients with sepsis.
Systemic immune-inflammation index (SII) has been identified as a prognostic biomarker for various diseases. Our study aimed to investigate the association between SII and mortality risk in critically ill patients with sepsis, thus exploring possible tools for rapid screening. This retrospective cohort study was conducted using clinical data extracted from the Medical Information Mart for Intensive Care Database. The study included only patients diagnosed with sepsis admitted to the intensive care unit for the first time. We used the restricted cubic splines to explore the relationship between SII and 28-day mortality. Kaplan-Meier curve and Cox regression models were performed to evaluate the association between SII and mortality. Subgroup analysis was performed to explore the stability of the primary results. A total of 16,007 patients with sepsis were eligible in the final analysis. We found a J-shaped relationship between SII and mortality risk. The SII level associated with the lowest mortality risk was 774.46*10(9)/L. Compared with the reference group (second SII quartile), the 28-day mortality was increased in the highest quartile and third quartile groups of SII levels; fully adjusted HRs were 1.16 (1.02 to 1.32) and 1.40 (1.23 to 1.58), respectively. However, although the lower SII (Q1 group) also showed a trend toward a higher hazard of 28-day mortality, there was no statistical difference, with a fully adjusted HR of 1.05 (0.92 to 1.21). In the population of critically ill patients with sepsis, low and high SII levels were associated with an increased risk of short-term mortality. The 28-day mortality risk was lowest at SII levels of 774.46*10(9)/L.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available